Articles tagged "Rejection"

2019 American Transplant Congress
Inadequate (ax) Transbronchial Biopsies Are Not Associated With Clad Or Death After Lung Transplantation
L. Levy¹, E. Huszti², J. Tikkanen³, R. Ghany³, S. Keshavjee³, T. Martinu³
¹Lung Transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada, ²Biostatistics Research Unit, University Health Network, University of Toronto, Toronto, ON, Canada, ³Lung transplant Program, University Health Network, University of Toronto, Toronto, ON, Canada
*Purpose: Acute cellular rejection (ACR) in lung transplantation is defined by perivascular and interstitial mononuclear infiltrates on lung allograft pathology. Procuring a good quality transbronchial…
2019 American Transplant Congress
Donor-Derived Cell-Free DNA (dd-cfDNA) Course after Rejection in Pediatric Kidney Transplant Recipients
R. D. Swinford¹, A. M. De Golovine¹, C. Bell¹, A. Pai¹, A. R. Edwards¹, S. Connor², J. S. Bynon¹
¹Pediatrics, UTHealth, McGovern Medical School, University of Texas at Houston, Houston, TX, ²Transplantation, Memorial Hermann Hospital, Houston, TX
*Purpose: Accurate identification of successful treatment for rejection (R) without repeat kidney biopsy (KB) in kidney transplantation is an unmet need. The few existing biomarkers…
2019 American Transplant Congress
IL-21 Induces the Transformation of Th Cell Subsets in Acute Rejection after Kidney Transplantation
H. Deng, R. Wang, J. Shen, J. Chen
Kidney Disease Center, First Affiliated Hospital of Zhejiang University, Hangzhou, China
*Purpose: IL-21 exhibits a wide range of immunomodulatory functions in the organism, regulating immune cells such as B cells and T cells. In this study,…
2019 American Transplant Congress
Molecular Analysis of Rejection and Injury in Human Liver Transplant Biopsies: First Results of the INTERLIVER Study
P. F. Halloran and The INTERLIVER Study Group
University of Alberta, Edmonton AB, AB, Canada
*Purpose: The relationship of histologic liver transplant biopsy assessments to actual rejection and injury is unclear. Recent progress in molecular reclassification of kidney, heart, and…
2019 American Transplant Congress
Targeted Proteomic Analysis Detects Acute T Cell-Mediated Kidney Allograft Rejection in Belatacept-Treated Patients
M. van der Zwan, D. A. Hesselink, M. C. Clahsen-van Groningen, C. C. Baan
Erasmus MC, Rotterdam, Netherlands
*Purpose: There is an unmet need for reliable minimally-invasive diagnostic biomarkers for immunological allograft monitoring and detection of acute kidney transplant rejection. Here, targeted proteomic…
2019 American Transplant Congress
Characterizing the Dominant Phenotype in Kidney Transplant Biopsies: Improving the Prediction of Risk by a Global View of Rejection, Injury, and Atrophy-Fibrosis
P. F. Halloran and The INTERCOMEX Investigators¹, J. Reeve²
¹University of Alberta, Edmonton, AB, Canada, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada
*Purpose: Interpreting kidney transplant biopsies by histology or molecules involves assigning scores for separate pathologic categories: rejection, acute injury (molecules only), and chronic parenchymal loss…
2019 American Transplant Congress
Rejection Of Optic And Sciatic Transplants
M. Yonar¹, M. Uehara¹, V. Kasinath¹, F. Bei², R. Abdi¹
¹Renal, Brigham and Women's Hospital, Boston, MA, ²Neurosurgery, Brigham and Women's Hospital, Boston, MA
*Purpose: Mechanisms of rejection of peripheral nerve and optic nerve remains largely unknown. The inability to prevent rejection of the optic nerve has thwarted the…
2019 American Transplant Congress
Integrative Analysis of Immune Repertoire and Gene Expression from RNA-seq in Kidney Organ Transplants
S. Pineda¹, A. Ravoor², O. Bestard³, M. Sarwal¹, M. Sirota²
¹Department of Surgery, UCSF, San Francisco, CA, ²BCHSI, UCSF, San Francisco, CA, ³Department of Surgery, 3Bellvitge University Hospital, Barcelona, Spain
*Purpose: The main problem with kidney transplantation is the possibility of rejection, which is classified as either antibody-mediated rejection (AMR) or T-cell-mediated rejection (TCMR) depending…
2019 American Transplant Congress
Mechanical Irritation in Vascularized Tissue Allotransplantation Triggers Localized Skin Rejection
F. Messner, A. Fischer, E. Runggaldier, S. Eiter, B. Zelger, B. Zelger, S. Sprung, D. Öfner, S. Schneeberger, T. Hautz
Department of Visceral, Transplant and Thoracic Surgery, Medical University of Innsbruck, Innsbruck, Austria
*Purpose: “Atypical” forms of skin rejection have been described in some hand transplanted patients mainly manifesting on the palm including dryness, scaling and thickening of…
2019 American Transplant Congress
Transcriptional Changes in PBMC Associated with Development of Infection and Rejection in Older and Younger Kidney Transplant Recipients
J. Schaenman¹, M. Rossetti², E. Liang¹, O. E. Beaird¹, S. Bunnapradist³, E. F. Reed², S. Cole⁴
¹Division of Infectious Diseases, David Geffen School of Medicine at UCLA, Los Angeles, CA, ²Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, ³Division of Nephrology, David Geffen School of Medicine at UCLA, Los Angeles, CA, ⁴Division of Hematology-Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Changes in immune response are central to vulnerability to infection and rejection, especially for the growing numbers of older kidney transplant recipients. We sought…