2019 American Transplant Congress
Early Steroid Withdrawal in African American Deceased Donor Renal Transplant Recipients with Alemtuzumab Induction: Is Graft Loss on the Horizon?
University of Maryland Medical Center, Baltimore, MD
*Purpose: The safety of early steroid withdrawal (ESW) in African American (AA) deceased donor renal transplant recipients (DDRTs) is unclear. This study assessed the impact…2019 American Transplant Congress
Using Ensembles of Machine Learning Classifiers to Maximize the Accuracy and Stability of Molecular Biopsy Interpretation
*Purpose: The Molecular Microscope diagnostic system (MMDx), based on microarray gene expression, uses ensembles of machine learning classifiers rather than single genes, gene sets, or…2019 American Transplant Congress
Predicting Transplant Rejection by a Composite Urinary Injury Score
Department of Surgery, UCSF, San Francisco, CA
*Purpose: While sequencing or SNP-based methods of quantifying donor-derived cell-free DNA (dd-cfDNA) from plasma have been used to detect allograft rejection, they remain expensive and…2019 American Transplant Congress
Single Nucleotide Polymorphisms in NFACT1 rs2290154 Associated with the Risk of T Cell-Mediated Rejection of Recipients Following Kidney Transplantation
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: Our study was to investigate the potential associations between the single nucleotide polymorphisms (SNPs) in NFATC1 and the risk of T cell-mediated rejection (TCMR)…2019 American Transplant Congress
BTLA Suppressed Acute Rejection by Regulating T Cell Receptor Downstream Signal Pathways and Cytokine Production in Renal Transplant and Contributed to Prolongation of Allograft Survival
No.300 Guangzhou Road of Nanjing, Nanjing, China
*Purpose: The present study aimed to investigate the role of BTLA in the progress of acute rejection after kidney transplantation.*Methods: In human allograft renal transplanted…2019 American Transplant Congress
External Validation of Donor-Derived Cell-Free DNA to Detect Rejection in Kidney Transplant Recipients
Cedars Sinai Medical Center, Los Angeles, CA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA; Allosure®, CareDx) became Medicare-reimbursable in the United States in October, 2017 for the detection of rejection in kidney transplant recipients…2019 American Transplant Congress
Molecular Phenotype of Proliferative Arteriopathy in Kidney Grafts
*Purpose: Proliferative arteriopathy (PA) is a lesion characterized by a fibrotic tissue in the arterial intima. The phenomenon is marked by the lack of elastic…2019 American Transplant Congress
Outcomes in Kidney Transplant Recipients after Conversion from Tacrolimus to Belatacept-Based Regimens
Columbia University Irving Medical Center, New York, NY
*Purpose: Immunosuppressive strategies for belatacept are variable and associated outcomes have not been well described. We examined outcomes among kidney transplant (KT) recipients converted from…2019 American Transplant Congress
Outcome Of Late Biopsy-negative Rejection After Heart Transplantation
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Biopsy-negative rejection (BNR) is an entity where the endomyocardial biopsy (EMB) shows no findings of rejection, but there is proven cardiac dysfunction i.e. low…2019 American Transplant Congress
Impact of Protease Inhibitor-Based Anti-Retroviral Therapy on Tacrolimus Intrapatient Variability in HIV+ Kidney Transplant Recipients
Houston Methodist Hospital, Houston, TX
*Purpose: High tacrolimus (FK) intra-patient variability (IPV) has been associated with inferior outcomes in solid organ transplantation. HIV+ transplant recipients have been shown to experience…
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