Articles tagged "Rejection"

2019 American Transplant Congress
Transplanting Thoracic Organs From Hcv Donors To Uninfected Patients: Evaluation Of Lung Allografts
Y. Lo¹, R. F. Padera¹, H. R. Mallidi², H. J. Goldberg³, S. K. Singh², A. Coppolino, III⁴, L. R. Baden⁵, A. E. Woolley⁵
¹Pathology, Brigham and Womens Hospital, Boston, MA, ²Cardiac and Thoracic Surgery, Brigham and Womens Hospital, Boston, MA, ³Pulmonary, Brigham and Womens Hospital, Boston, MA, ⁴Thoracic Surgery, Brigham and Womens Hospital, Boston, MA, ⁵Infectious Diseases, Brigham and Womens Hospital, Boston, MA
*Purpose: Prior to the development of direct acting antiviral (DAA) therapy for hepatitis C virus (HCV), there was concern that patients who received lungs from…
2019 American Transplant Congress
The Role of the T Regulatory Cell Compartment in Intestinal Transplant Patients: Helpful or Unhinged?
L. Belyayev¹, M. Sadat², K. Loh³, S. Moturi², K. Khan², J. Hawksworth², C. Matsumoto², T. M. Fishbein², A. Kroemer²
¹Surgery, Walter Reed National Military Medical Center, Bethesda, MD, ²Transplant, MedStar Georgetown Transplant Institute, Washington D.C., DC, ³Pediatrics, Children’s National Medical Center, Washington D.C., DC
*Purpose: The T regulatory (Treg) cell compartment has now been established as a key player in dampening T helper 17 (Th17) mediated inflammation, managing self-tolerance,…
2019 American Transplant Congress
Quantitative Proteome Profiling in T Cell-Mediated Rejection
L. Song¹, G. Zeng², P. Liu³, F. Fang⁴, H. Liu⁴, X. Xie¹, P. Randhawa², K. Xiao⁴
¹Department of Urological Organ Transplantation, The Second Xiangya Hospital, Central-South University, Changsha, China, ²Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA, ³Department of Biostatistics, Graduate School of Public Health, and Departments of Pharmacology and P, University of Pittsburgh Medical Center, Pittsburgh, PA, ⁴Department of Pharmacology and Chemical Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA
*Purpose: The proteomic analyses through formalin-fixation and paraffin embedding (FFPE) specimens reflects systemic and inherent renal injury perturbations for different kidney transplant injury states. In…
2019 American Transplant Congress
Functional Characterization of Orthotopic Hind-Limb Transplants in Rats
F. Zheng, X. Zhang, L. Qiu, J. Wang, X. Yeap, K. M. Koss, J. Wertheim, Z. J. Zhang
Comprehensive Transplant Center and Department of Surgery, Northwestern University, Chicago, IL
*Purpose: Vascularized composite allotransplantation (VCA) is a valid therapeutic option for patients with non-salvageable injuries such as severe burns or limb amputation. The immune response…
2019 American Transplant Congress
RNA Sequencing Identifies a Differential Role of Coding and Non-Coding Genes by Types of Rejection
S. Pineda¹, O. Bestard², T. K. Sigdel¹, M. Sirota³, M. Sarwal¹
¹Department of Surgery, UCSF, San Francisco, CA, ²Department of Surgery, Bellvitge University Hospital, Barcelona, Spain, ³BCHSI, UCSF, San Francisco, CA
*Purpose: The differentiation of histological phenotypes of T cell mediated cellular rejection (TCMR) and humoral or antibody mediated rejection (AMR) of kidney allografts, bears relevance…
2019 American Transplant Congress
Early Conversion to Belatacept in High Risk Renal Transplant Recipients
A. Santeusanio, A. Bhansali, R. Shapiro, V. Delaney, S. Florman, G. De Boccardo
Mount Sinai Hospital, New York, NY
*Purpose: This study describes our experience with early conversion to belatacept therapy in a diverse patient population including patients with donor specific antibodies (DSA). The…
2019 American Transplant Congress
Global Analysis of Fc-gamma Receptors Binding Capacity of Human Leukocyte Antigen Donor Specific Antibody
E. S. Woodle, A. Girnita
University of Cincinnati Academic Health Center, Cincinnati, OH
*Purpose: Functional assessment of anti-HLA antibodies has historically been limited to complement-binding assays. However, antibodies are capable of inducing injury by complement-independent mechanisms, including Fc-gamma…
2019 American Transplant Congress
Hepatitis Flare in Hepatitis B Core Antibody Positive Kidney Recipients Treated with Rituximab
M. Raja¹, Y. Natori¹, C. Donato¹, D. De Lima¹, J. Rivollo², A. Centeno², Y. Ebisu¹, L. Abbo¹, J. Simkins¹, S. Anjan¹, J. Camargo¹, M. I. Morris¹
¹Internal Medicine, University of Miami Miller School of Medicine, Miami, FL, ²Jackson Memorial Hospital, Miami, FL
*Purpose: Patients with Hepatitis B Core Antibody (anti-HBc Ab) positive are known to be at risk for Hepatitis B virus (HBV) reactivation during periods of…
2019 American Transplant Congress
Subclinical Rejection is Common on Surveillance Biopsies in Children with Kidney Transplant
S. Gattis¹, R. Liverman¹, A. Serluco¹, J. Yin¹, J. Hogan², S. Jernigan², R. George², P. D. Winterberg², R. Garro²
¹Children's Healthcare of Atlanta, Atlanta, GA, ²Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
*Purpose: Surveillance biopsies provide the opportunity to identify subclinical rejection and other pathologic changes, yet their utilization varies across pediatric kidney transplant centers. The purpose…
2019 American Transplant Congress
Impact of T-cell Mediated Allograft Rejection and Antibody Mediated Rejection within the First Year after Kidney Transplantation
I. Owoyemi, D. Jorgensen, S. Tandukar, R. Mehta, S. Hariharan
Thomas E. Starzl Institute of Transplantation and Division of Transplant Nephrology, UPMC, Pittsburgh, PA
*Purpose: This study evaluated the impact of Clinical and Sub-clinical T-Cell-Mediated Rejection (TCMR), Sub-Clinical Inflammation and Antibody Mediated Rejection (ABMR) within the 1st year post-kidney…