Articles tagged "Rejection"

2019 American Transplant Congress
Prevalence of Donor Specific Antibody in Heart Transplant Recipients with Antibody-Mediated Rejection as Compared to Abnormal Intragraft mRNA Transcripts by Molecular Microscope System
K. Shah, R. J. Levine, S. Dimbil, S. Sana, P. F. Halloran, J. Patel, D. H. Chang, E. Kransdorf, M. Kittleson, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Antibody-mediated rejection (AMR) is defined by pathologic evaluation of endomyocardial biopsy (EMB) for both histologic and immunopathologic components. Detectable donor specific antibodies (DSAs) in…
2019 American Transplant Congress
High HLA-DQ Epitope Mismatch Load and Low Tacrolimus Level Are Associated with Development of De Novo Donor Specific Antibody
D. Lee¹, B. Kim², J. Kim³, I. Kim⁴, M. Jeon⁵, J. Ahn¹, S. Choi⁶
¹Nephrology, Maryknoll Medical Center, Busan 48972, Korea, Republic of, ²Laboratory Medicine, Maryknoll Medical Center, Busan 48972, Korea, Republic of, ³Surgery, Maryknoll Medical Center, Busan 48972, Korea, Republic of, ⁴Urology, Maryknoll Medical Center, Busan 48972, Korea, Republic of, ⁵Pathology, Maryknoll Medical Center, Busan 48972, Korea, Republic of, ⁶Transplantation Center, Coordinator : Nurse, Maryknoll Medical Center, Busan 48972, Korea, Republic of
*Purpose: Purpose of our study is to evaluate the clinical significance of HLA class II epitope mismatch loads for the development of de novo DSA…
2019 American Transplant Congress
Effects of Proton Pump Inhibitors on Allograft Rejection and Adverse Effects in Kidney Transplant Recipients: A Systemic Review and Meta-Analysis
B. Boonpheng¹, C. Thongprayoon², M. A. Mao³, W. Cheungpasitporn⁴
¹Internal Medicine, East Tennessee State University, Johnson City, TN, TN, ²Nephrology, Mayo Clinic, Rochester, MN, MN, ³Nephrology, Mayo Clinic, Rochester, MN, ⁴Internal Medicine, University of Mississippi Medical Center, Jackson, MI, MS
*Purpose: The adverse renal effects of proton pump inhibitors (PPIs) are being increasingly recognized in both the general population and chronic kidney disease patients. Several…
2019 American Transplant Congress
Immunosuppression Reduction after Diagnosis of Sustained BK Viremia and the Risk of Allograft Rejection, Allograft Loss and Mortality
F. A. Al Dhufairi¹, M. Shokoohi², A. M. Jevnikar¹, A. A. House¹, D. Kumar³, S. M. Hosseini-Moghaddam¹
¹Department of Medicine, Western University, London Health Sciences Centre, London, ON, Canada, ²Epidemiology and Biostatistics, Western University, London, ON, Canada, ³Department of Medicine, University Of Toronto, University Health Network, Toronto, ON, Canada
*Purpose: BK viremia increases the risk of allograft loss after renal transplantation. Current guidelines recommend immunosuppression reduction (IsR) after the diagnosis of BK viremia. The…
2019 American Transplant Congress
Incidence of De Novo Donor Specific Antibodies and Treatment Response for AMR in Pediatric Kidney Transplant Recipients
S. Gattis¹, R. Liverman¹, A. Serluco¹, J. Yin¹, H. C. Sullivan², R. A. Bray³, H. M. Gebel³, S. Jernigan⁴, R. George⁴, P. D. Winterberg⁴, R. Garro⁴
¹Children's Healthcare of Atlanta, Atlanta, GA, ²Department of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, ³Emory University Hospital, Atlanta, GA, ⁴Department of Pediatrics, Emory University School of Medicine, Atlanta, GA
*Purpose: Antibody-mediated rejection (AMR) is a significant complication in renal transplant patients. The aim of this study was to evaluate the incidence of de novo…
2019 American Transplant Congress
Thymoglobulin Efficacy: The Role of Dosing on Viral Infection and Rejection in Pancreas Transplantation
H. Sarumi, B. Johnson, S. Jackson, S. Hogan, J. Fisher, S. Riad, R. Kandaswamy, T. Pruett
Transplant Surgery, University of Minnesota Medical Center, Minneapolis, MN
*Purpose: While T-cell depletion therapy is standard practice for induction in pancreas transplantation, little data exists to help determine dosing and its impact on efficacy…
2019 American Transplant Congress
Bisphosphonates Effectively Improve the Long Term Renal Transplant Outcomes; A Single Center Retrospective Study
S. Song¹, K. Huh², H. Choi³, J. Lee², D. Kim², Y. Kim², M. Kim², S. Kim², D. Joo², B. Kim³
¹Surgery, Ewha Womans University, Seoul, Korea, Republic of, ²Surgery, Yonsei University College of Medicine, Seoul, Korea, Republic of, ³Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, Republic of
*Purpose: Kidney transplantation (KT) is a treatment of choice for patients with end-stage renal disease. Despite of remarkable improvement in short term graft survival, few…
2019 American Transplant Congress
Prognostic Value of C3d Fixing Preformed Donor-Specific Antibody in Crossmatch-Positive Living Kidney Transplantation
K. Miyake¹, M. Okumi¹, Y. Kakuta¹, K. Unagami², M. Furusawa¹, H. Ishida², K. Tanabe¹
¹Urology, Tokyo Women's Medical University, Sinjuku, Japan, ²Organ Transplant Medicine, Tokyo Women's Medical University, Sinjuku, Japan
*Purpose: The occurrence of acute antibody-mediated rejection (ABMR) was higher in flow cytometric crossmatch (FCXM)-positive patients despite desensitization, and complement binding ability of donor specific…
2019 American Transplant Congress
Long Term Outcomes Using Tocilizumab For The Treatment Of Chronic Antibody Mediated Rejection
J. Choi¹, E. Huang¹, O. Aubert², A. Vo¹, A. Peng¹, R. Najjar¹, S. Sethi¹, N. Ammerman¹, K. Lim¹, D. Puliyanda¹, A. Loupy², S. Jordan¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, ²Paris Translational Center for Organ Transplantation, Paris, France
*Purpose: Limited options exist for the treatment of kidney allograft rejection and preservation of allograft function. We reported our experience with anti-IL-6R (tocilizumab, TCZ) as…
2019 American Transplant Congress
Local IL-33 Regulates Heart Transplant Infiltrating Myeloid Cells Metabolism and Differentiation to Protect against Chronic Rejection
Z. Zhang¹, Q. Liu¹, T. Li¹, G. S. Hussey², M. Velayutham¹, J. L. Dziki², L. R. Mathews¹, Y. C. Lee², G. K. Dwyer¹, H. Dai¹, A. S. Roessing¹, S. Shiva³, M. H. Oberbarnscheidt¹, S. F. Badylak², H. R. Turnquist¹
¹Department of Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ²Department of Bioengineering, McGowan Institute for Regenerative Medicine, Pittsburgh, PA, ³Department of Pharmacology and Chemical Biology, Vascular Medicine Institute, Pittsburgh, PA
*Purpose: Self-molecules containing damage-associated molecular patterns stimulate the pro-inflammatory response of infiltrating innate immune cells after their release during tissue injury. Yet, if local endogenous…