Articles tagged "Rejection"

2019 American Transplant Congress
Back Signaling of HLA Class I Molecules and NK Cell Receptor Ligands in Renal Epithelial Cells Contributes to the Rejection-Specific Microenvironment
E. Chichelnitskiy¹, J. Egelkamp¹, K. Daemen¹, J. Keil¹, C. Neudörfl¹, J. Bräsen², J. Schmitz², H. Haller³, C. Blume⁴, C. Falk⁵
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Nephropathology Unit, Institute of Pathology, Hannover Medical School, Hannover, Germany, ³Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany, ⁴Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany; Institute of Technical Chemistry, Leibniz University, Hannover, Germany, ⁵Institute of Transplant Immunology, Hannover Medical School; DZIF, German Center for Infection Research, TTU-IICH, Hannover/Braunschweig, Germany
*Purpose: During the last years, diverse harming mechanisms of donor-specific antibodies (DSA) to endothelial cells have been studied accompanied by an emerging evidence of NK…
2019 American Transplant Congress
Outbreak of Pneumocystis Pneumonia in a Transplant Center Linked to a Single Genotype of Pneumocystis jirovecii: Effects of Cytomegalovirus Infection and Allograft Rejection
S. Hosseini-Moghaddam¹, S. Dufresne², M. Shokoohi³, G. Singh¹, E. HunterGutierrez¹, P. Dufresne², A. House¹, P. Luke¹, A. Nagpal¹, P. Marotta¹, A. Humar⁴, A. Jevnikar¹, D. Kumar⁴
¹Western University,LHSC,University Hospital, London, ON, Canada, ²Maisonneuve-Rosemont Hospital,Université de Montréal, Montreal, QC, Canada, ³Epidemiology and Biostatistics, Western University, London, ON, Canada, ⁴University of Toronto, University Health Network, Toronto General Hospital, Toronto, ON, Canada
*Purpose: Although post-transplant pneumocystis pneumonia (PCP) outbreaks have been reported from Asia, Australia and Europe, there are limited data from North America. We investigated transmissibility…
2019 American Transplant Congress
Liver Allograft Provides Protection Against Cardiac Allograft Rejection In Combined Heart And Liver Transplantation
K. Zhao¹, R. Wang², M. Kamoun³, K. Olthoff¹, M. Hoteit⁴, E. Rame⁵, M. Levine¹, R. Mclean⁵, P. Abt¹
¹Surgery, University of Pennsylvania, Philadelphia, PA, ²Jefferson University, Philadelphia, PA, ³Pathology, University of Pennsylvania, Philadelphia, PA, ⁴Gastroenterology, University of Pennsylvania, Philadelphia, PA, ⁵Cardiology, University of Pennsylvania, Philadelphia, PA
*Purpose: Combined heart-liver transplant (CHLT) is indicated for patients with combination of heart and liver disease or amyloid heart disease for whom liver transplant can…
2019 American Transplant Congress
Anti-Complement Component 5 Antibody Based Immunosuppression Induced Accommodation in ABO Incompatible Heart Transplantation
S. Park¹, S. Lee¹, J. Hwang¹, J. Ryu², T. Koo², C. Ahn³, J. Yang⁴
¹Biomedical Research Institute, Seoul National University Hospital, Seoul, Korea, Republic of, ²Transplantation Center, Seoul National University Hospital, Seoul, Korea, Republic of, ³Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea, Republic of, ⁴Department of Surgery, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Plasmapheresis in combination with immunoglobulin and rituximab is often used to induce accommodation in ABO-incompatible (ABOi) living-donor transplantation; however, this regimen cannot be applied…
2019 American Transplant Congress
Decreased Rejection and Higher Graft Survival in Pediatric Deceased Donors
P. Budhiraja¹, D. Rotich², J. Mahnken², A. Ilahe¹, A. Naik³, D. Cibrik¹
¹Nephrology, University of Kansas Medical Center, Kansas City, KS, ²Statistics, University of Kansas, Kansas City, KS, ³Nephrology, University of Michigan, Ann Arbor, MI
*Purpose:Pediatric donor kidneys are important pool of donor kidneys which despite the early surgical complications have good long-term graft survival.1 We hypothesize that this survival…
2019 American Transplant Congress
Impact of the 2013 Change in Definition of Increased Risk Donors on Lung Transplant Outcomes
C. J. Lehr¹, R. Lopez², S. Arrigain², J. D. Schold², M. Valapour¹
¹Respiratory Institute, Cleveland Clinic, Cleveland, OH, ²Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH
*Purpose: The definition for donors at “increased risk” for human immunodeficiency virus (HIV), hepatitis B (HBV), and hepatitis C (HCV) was updated in 2013 from…
2019 American Transplant Congress
Outcomes Of Treatment Of Late Vs Early Acute Antibody-mediated Rejection In Renal Transplant Recipients – A Single Center Experience
R. Prashar, N. Sulejmani, A. Patel
Henry Ford Transplant Institute, Detroit, MI
*Purpose: The diagnostic accuracy and treatment options for acute antibody-mediated rejection (aABMR) in RTRs has improved over the last several years. However,response to treatment in…
2019 American Transplant Congress
The Impact of Acute Rejection in Heart Transplantation on Post-Transplant Malignancy
K. Kamrani¹, A. Okoh², D. Hanos¹, M. Camacho¹, M. Zucker², K. Clarke¹
¹Dept. of Surgery, Newark Beth Israel Medical Center, Newark, NJ, ²Dept. of Medicine, Newark Beth Israel Medical Center, Newark, NJ
*Purpose: Compared with the general population, an increased incidence of skin cancers and lymphomas have been shown in orthotopic heart transplant (OHT) recipients. However, the…
2019 American Transplant Congress
Long-Term Outcomes of Eculizumab-Treated Positive Crossmatch Recipients: Allograft Survival, Histologic Findings, and Natural History of the Donor-Specific Antibodies
C. Schinstock, A. Bentall, S. Byron, L. Cornell, M. Everly, M. Gandhi, M. Stegall
Mayo Clinic, Rochester, MN
*Purpose: We aimed to determine long-term outcomes for eculizumab-treated, positive crossmatch (+XM) kidney transplant recipients as compared with +XM and age-matched negative crossmatch (−XM) control…
2019 American Transplant Congress
Inhibition of mTORC2 Causes Hyper Phosphorylation of ERK Induced by Co-Ligation of HLA-I and II Antibody
Y. Jin¹, J. Sinnet-Smith², E. Rozengurt², E. F. Reed¹
¹Pathology and Laboratory Medicine, University of California Los Angeles, Los Angeles, CA, ²Medicine, University of California Los Angeles, Los Angeles, CA
*Purpose: Transplant recipients developing donor specific antibodies (DSA) are at risk for antibody-mediated rejection (AMR). It has been reported that as many as 30% of…