Articles tagged "Rejection"

2019 American Transplant Congress
Long Term Outcomes Using Tocilizumab For The Treatment Of Chronic Antibody Mediated Rejection
J. Choi¹, E. Huang¹, O. Aubert², A. Vo¹, A. Peng¹, R. Najjar¹, S. Sethi¹, N. Ammerman¹, K. Lim¹, D. Puliyanda¹, A. Loupy², S. Jordan¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, ²Paris Translational Center for Organ Transplantation, Paris, France
*Purpose: Limited options exist for the treatment of kidney allograft rejection and preservation of allograft function. We reported our experience with anti-IL-6R (tocilizumab, TCZ) as…
2019 American Transplant Congress
Local IL-33 Regulates Heart Transplant Infiltrating Myeloid Cells Metabolism and Differentiation to Protect against Chronic Rejection
Z. Zhang¹, Q. Liu¹, T. Li¹, G. S. Hussey², M. Velayutham¹, J. L. Dziki², L. R. Mathews¹, Y. C. Lee², G. K. Dwyer¹, H. Dai¹, A. S. Roessing¹, S. Shiva³, M. H. Oberbarnscheidt¹, S. F. Badylak², H. R. Turnquist¹
¹Department of Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ²Department of Bioengineering, McGowan Institute for Regenerative Medicine, Pittsburgh, PA, ³Department of Pharmacology and Chemical Biology, Vascular Medicine Institute, Pittsburgh, PA
*Purpose: Self-molecules containing damage-associated molecular patterns stimulate the pro-inflammatory response of infiltrating innate immune cells after their release during tissue injury. Yet, if local endogenous…
2019 American Transplant Congress
Monitoring Circulating T Follicular Helper Cells Polarization, Activation and Function Distinguishes Asymptomatic Donor-Specific Anti-HLA Antibody Positive Kidney Transplant Recipients from Those Undergoing Antibody-Mediated Rejection
C. Macedo¹, K. Louis¹, P. Fadakar², M. Yamada², B. Elinoff¹, K. Hadi¹, P. Randhawa¹, D. Metes¹
¹Starzl Transplantation Institute, Pittsburgh, PA, ²Children's Hospital of Pittsburgh, Pittsburgh, PA
*Purpose: Donor-specific anti-HLA antibodies (DSA) represent an important biomarker for acute rejection and are a major cause of long-term graft failure after kidney transplantation (KTx).…
2019 American Transplant Congress
Donor-derived Cell-free Dna In Donor Specific Antibody Positive Kidney Transplant Recipients
D. Cheng¹, X. Li², T. Jiang², H. Liu², Y. Zhou³, H. Shi³
¹National Clinical Research Center of Kidney Diseases, Jinling Hospital, Nanjing University School of Medicine, Nanjing, China, ²Research and Development, AlloDx Biotech Co.Ltd., Suzhou, China, ³Precise Medicine Center, Biology and Science School, JiangSu University, Zhenjiang, China
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is an emerging biomarker of kidney allograft injury. Studies examining the clinical validity of this biomarker have identified cut off…
2019 American Transplant Congress
The Polish Troubled Kidney Transplant Biopsy Study: External Validation of the Molecular Microscope System
M. Myślak¹, D. Deborska-Materkowska², M. Ciszek², J. Mazurkiewicz¹, A. Debska-Slizien³, P. F. Halloran⁴, A. Perkowska-Ptasińska⁵
¹Pomeranian Medical University, Szczecin, Poland, ²Warsaw Medical Univeristy, Warsaw, Poland, ³Gdansk Medical University, Gdansk, Poland, ⁴Alberta Transplant Applied Genomics Centre, University of Alberta, Edmonton AB, AB, Canada, ⁵Medical University of Warsaw, Warsaw, Poland
*Purpose: The transplant clinician frequently encounters kidney transplant biopsies that are difficult to interpret by histology. A Molecular Microscope Diagnostic System (MMDx) has been developed…
2019 American Transplant Congress
CD56+CD57+ Infiltrate is a Predominant Subset of Infiltrating Natural Killer Cell in Renal Transplant Biopsies with Antibody-Mediated Rejection
H. Jung¹, Y. Wee², J. Kim², M. Choi², J. Choi², H. Kwon², J. Jung², S. Kim³, Y. Cho⁴, Y. Park⁴, H. Go⁴, M. Han⁵, Y. Kim², D. Han², S. Shin²
¹Department of Biomedical Science, Asan Medical Institute of Convergence Science and Technology (AMIST), Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ²Division of Kidney and Pancreas Transplantation, Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ³Department of Convergence Medicine, Asan Institute for life sciences, Asan Medical Center, Seoul, Korea, Republic of, ⁴Department of Pathology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of, ⁵Department of Clinical Epidemiology, Asan Medical Center, Seoul, Korea, Republic of
*Purpose: To verify a subset of intragraft and circulating natural killer cells associated with kidney allograft rejection and fibrosis.*Methods: Thirty-nine clinically indicated transplant biopsies performed…
2019 American Transplant Congress
Is Bariatric Surgery Feasible in the Setting of Liver and Kidney Transplants?
L. M. Potter, A. Saharia, C. Mobley, K. Lunsford, M. Hobeika, N. Tariq, H. Podder, A. O. Gaber, R. M. Ghobrial
Liver Transplant and Hepatobiliary Surgery, The Houston Methodist Hospital, Houston, TX
*Purpose: Bariatric surgery benefits obese patients by promoting weight loss, improving quality of life, and reducing morbidity and mortality rates. There is concern, however, that…
2019 American Transplant Congress
Reference Ranges Donor-Derived Cell-Free DNA in a Heart Transplant Population
A. Kao¹, S. Dholakia², M. Deng³
¹Saint Luke's, Kansas City, MO, ²CareDx, Brisbane, CA, ³University of Los Angeles, Los Angeles, CA
*Purpose: Elevations in donor-derived cell-free DNA (dd-cfDNA) ≥0.20 % in heart transplant recipients (HTR) has been shown to be associated with a probability of acute…
2019 American Transplant Congress
Using a Massive Open Online Course on Clinical Kidney, Prancreas and Islet Transplantion in Different Settings of Transplant Education
P. G. De Jong¹, R. A. Hendriks¹, F. Luk², M. E. Reinders²
¹Center for Innovation in Medical Education, Leiden University Medical Center, Leiden, Netherlands, ²Internal Medicine, Leiden University Medical Center, Leiden, Netherlands
*Purpose: In 2016 our center launched a Massive Open Online Course (MOOC) on Kidney, Pancreas and Islet Transplantation. As opposed to on-campus education, this course…
2019 American Transplant Congress
Outcomes of Phenotypes in Early Subclinical Inflammation (SCI) Determined by Presence of Interstitial Inflammation with or without Concomitant Tubulitis
R. Mehta, S. Tandukar, D. Jorgensen, I. Owoyemi, P. Sood, A. Tevar, S. Hariharan
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Low levels of renal allograft inflammation in the early post transplant period appear to have an impact on renal architecture and function. However, the…