Articles tagged "Rejection"

2020 American Transplant Congress
Parathyroidectomy Post Kidney Transplant: A Single Center Report of Short Term Outcomes
S. Ong, F. Saad, K. Wille, C. Kew
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Whether parathyroidectomy in ESRD patients should be performed before or after kidney transplant remains controversial. There is concern that post-transplant parathyroidectomy can adversely affect…
2020 American Transplant Congress
Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) in Renal Allograft Biopsies (Bx) Are Beneficial to Clarifying ABMR Activity in Ambivalent Cases
H. Zhang¹, C. C. Nast², N. Ammerman³, A. A. Vo³, I. Gallegos³, M. Arevalo³, S. C. Jordan³, M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: “Thoroughly validated gene transcripts” in renal Bx was adopted as one of the criteria for ABMR diagnosis in the latest Banff classification. Here, we…
2020 American Transplant Congress
Change In i-IFTA Associated with Treatment of Rejection
N. Garg, B. C. Astor, S. Parajuli, F. Aziz, M. Mohamed, W. Zhong, A. Djamali, D. A. Mandelbrot
UW-Madison, Madison, WI
*Purpose: Recent studies have shown that inflammation in areas of interstitial fibrosis and tubular atrophy (i-IFTA) is associated with worse kidney allograft outcomes. How i-IFTA…
2020 American Transplant Congress
Novel Role of Qa-1, a Murine Homolog of HLA-E, in Controlling Follicular Helper T Cells During Humoral Alloimmunity
J. Y. Choi¹, S. K. Eskandari¹, S. Cai¹, J. Assaker¹, I. Sulkaj¹, H. Allos¹, J. Alhaddad¹, P. Chu¹, H. Kim², H. I. Cantor², J. R. Azzi¹
¹Medicine, Brigham and Women's Hospital, Boston, MA, ²Immunology, Dana Farber Cancer Institute, Boston, MA
*Purpose: Antibody-mediated rejection (AMR) is a major challenge in prolonging allograft survival. Limited insight into the humoral alloimmunity hinders the development of therapeutic strategies. We…
2020 American Transplant Congress
The Use of Cell-Free MicroRNAs for the Diagnosis of Allograft Rejection in Liver Transplant Recipients Using Standard and Novel Direct Detection Platforms
T. Kohut¹, B. Chang², J. Wen¹, A. Shaked², B. Keating²
¹Division of Gastroenterology, Hepatology & Nutrition, Department of Pediatrics, The Children's Hospital of Philadelphia, Philadelphia, PA, ²Hospital of the University of Pennsylvania, Penn Transplant Institute, Philadelphia, PA
*Purpose: Standard immunosuppression therapy (IST) in liver transplant (LTx) recipients requires a delicate balance to prevent side effects and allograft rejection (AR). There is no…
2020 American Transplant Congress
Improved Platelet Sequestration with Humanization of Von Willebrand Factor in Pig Xenogeneic Lung Perfusion Model
M. R. Connolly¹, L. Burdorf¹, Z. Abady¹, S. Sendil², E. Redding², B. Cerel¹, S. Pratts¹, C. Phelps³, W. Eyestone³, D. Ayares³, A. Azimzadeh¹, R. N. Pierson III¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²University of Maryland, Baltimore, Baltimore, MD, ³Revivicor, Blacksburg, VA
*Purpose: Von Willebrand factor (vWF) is an important element of hemostasis and when activated, mediates platelet adhesion and promotes platelet aggregation under shear stress conditions.…
2020 American Transplant Congress
FcγRIIIb Inhibits Renal Transplant Rejection by Inducing Neutrophils Apoptosis
J. Zhang, J. Chen
Kidney Disease Center, The First Affiliated Hospital of Zhejiang University, Hangzhou, China
*Purpose: Fcγ receptors (FcγR) have been proposed to be involved in the pathogenesis of acute rejection (AR) after organ transplantation. However, the mechanisms by which…
2020 American Transplant Congress
Treatment of Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients is Associated with Increased Risk of Urinary Tract Infections and Pneumonia
E. Joachim, S. Parajuli, K. Swanson, F. Aziz, N. Garg, M. Mohamed, D. Mandelbrot, A. Djamali
University of Wisconsin, Madison, WI
*Purpose: Infections are a common cause of morbidity and mortality after kidney transplantation. Chronic active antibody mediated rejection (cABMR) is a leading cause of kidney…
2020 American Transplant Congress
Remote Steroid Wean is Safe When Compared to Early Wean in Heart Transplant Recipients
B. C. Salgado, J. Krisl, E. A. Graviss, D. T. Nguyen, A. Bhimaraj, A. Guha
Cardiovascular Disease, Heart Failure and Transplant, Houston Methodist Hospital, Houston, TX
*Purpose: The risks and benefits of remote steroid wean in heart transplant recipients is unknown. We compared outcomes in patients undergoing early and remote steroid…
2020 American Transplant Congress
Specific Gut Microbiota Community Suppresses Acute Rejection by Reducing Natural Killer Cell Population
W. Zhang, L. Gong, Y. Xu, X. Hu
Department of Urology, Capital Medical University Beijing Chaoyang Hospital, Urology Institute of Capital Medical University, Beijing, China
*Purpose: The gut microbiota community was reported to be altered by high-dose FK506 treatment, while fecal microbiota transplantation with such microbiota plus low-dose FK506 could…