Articles tagged "Rejection"

2020 American Transplant Congress
ATHENA – Patient and Allograft Outcome Differences after Kidney Transplantation – Germany vs. France
F. Thaiss¹, C. Sommerer¹, B. Suwelack¹, D. Dragun¹, I. A. Hauser¹, O. Witzke¹, C. Hugo¹, P. Schenker¹, N. Kamar², P. Merville², I. Kroeger³, M. Junge³, B. Nashan¹
¹Athena, Study Group, Germany, ²Athena, Study Group, France, ³Novartis Pharma GmbH, Nürnberg, Germany
*Purpose: In the ATHENA trial [NCT01843348], efficacy and safety of everolimus in combination with tacrolimus [EVR+TAC] or cyclosporine A [EVR+CyA] vs. TAC and mycophenolic acid…
2020 American Transplant Congress
HLA Molecular Mismatch is an Independent Correlate of T-Cell Mediated Rejection and Potential Prognostic Biomarker in Renal Transplantation
C. Wiebe¹, D. Pochinco², I. W. Gibson³, J. Ho¹, P. Birk⁴, A. Goldberg⁴, M. Karpinski⁵, J. Shaw⁵, R. N. David⁵, P. W. Nickerson¹
¹Medicine and Immunology, University of Manitoba, Winnipeg, MB, Canada, ²Shared Health Services, Winnipeg, MB, Canada, ³Pathology, University of Manitoba, Winnipeg, MB, Canada, ⁴Pediatrics and Child Health, University of Manitoba, Winnipeg, MB, Canada, ⁵Medicine, University of Manitoba, Winnipeg, MB, Canada
*Purpose: HLA molecular mismatch alloimmune risk categorization has correlated with de novo donor-specific antibody (dnDSA) development, however, correlation with T-cell mediated rejection (TCMR) phenotypes is…
2020 American Transplant Congress
Clinical Significance of C4d and HLA-DSA on Post-Transplant Clinical Outcomes in Kidney Transplant Recipients with Antibody-Mediated Rejection
W. Park, O. Kwon, Y. Kim, J. Paek, K. Jin, S. Park, S. Han
Internal Medicine, Keimyung University School of Medicine, Keimyung University Kidney Institute, Daegu, Korea, Republic of
*Purpose: The clinicopathological diagnosis of rejection after kidney transplantation (KT) was well defined by Banff classification. In the diagnosis of antibody-mediated rejection (AMR), the presence…
2020 American Transplant Congress
Single versus Dual Immunosuppression in Liver Transplantation for Autoimmune Liver Diseases
S. Sterling¹, S. Hamel¹, C. Garza¹, I. Feurer², S. Rega², S. Alexopoulos³, M. Izzy⁴
¹Pharmacy, Vanderbilt University Medical Center, Nashville, TN, ²Vanderbilt Transplant Center, Nashville, TN, ³Liver Transplant Surgery, Vanderbilt Transplant Center, Nashville, TN, ⁴Transplant Hepatology, Vanderbilt Transplant Center, Nashville, TN
*Purpose: There is limited evidence on the optimal maintenance immunosuppression after liver transplant (LT) for primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC), and autoimmune…
2020 American Transplant Congress
Influence of the Gut Microbiota on Acute Rejection of Vascular Allografts
J. C. Choy, K. Rey, W. Enns, T. Van Rossum, F. S. Brinkman
Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, BC, Canada
*Purpose: The gut microbiota influences immune responses in many ways but its involvement in transplant rejection is poorly understood. We have examined how changes in…
2020 American Transplant Congress
Differences in Alemtuzumab Dosing Does Not Affect Early Kidney Transplant Outcomes
A. Pressley, R. Stratta, J. Rogers, A. Farney, G. Orlando, W. Doares, A. Reeves-Daniel, C. Jay
Wake Forest Baptist Health, Winston-Salem, NC
*Purpose: Alemtuzumab (Alem) is a widely used medication for induction therapy in kidney transplantation. However, there is limited evidence comparing outcomes with low versus high…
2020 American Transplant Congress
Efficacy & Safety of Once Daily Tacrolimus Compared to Twice Daily Tacrolimus after Liver Transplantation
K. Bzeizi, A. Albenmousa, M. Shawkat, W. Alhamoudi, S. Alabad, R. Troisi, D. Broering
KFSHRC, Riyadh, Saudi Arabia
*Purpose: To compare the efficacy and safety of once daily prolonged release tacrolimus compared to twice daily tacrolimus in liver transplantation patients*Methods: Medline, EMBASE, CENTRAL…
2020 American Transplant Congress
The Art Rather Than the Science of Non-HLA Antibody Mediated Rejection in Heart Transplantation: A Single Center Experience
A. Alam, S. Mckean, R. Patel, V. Darst, H. Zafar, C. Guerrero, M. Askar, T. Sam, S. Hall
Cardiology, Baylor University Medical Center, Dallas, TX
*Purpose: The role of non-HLA antibodies (Ab) in HLA-DSA negative antibody mediated rejection (AMR) following heart transplant (HTx) remains largely unknown.*Methods: Retrospective analysis of all…
2020 American Transplant Congress
The 1st Year Posttransplant Course Reliably Predicts Kidney Graft Survival up to 15 Years Using a Machine Learning-Based Modeling Approach
W. Gwinner, M. Gietzelt, R. Hanna, A. A. Khalifa, M. Hallensleben, M. Marschollek, H. Haller, J. H. Braesen, I. Scheffner
Hannover Medical School, Hannover, Germany
*Purpose: Identification of patients at risk for graft failure can improve individual surveillance and early therapeutic interventions. We used a well-documented patient cohort to establish…
2020 American Transplant Congress
The Role of Th17 Polarized T Regulatory Cells in Intestinal Transplant Rejection
L. Belyayev¹, M. Sadat², J. Kang², K. Loh², A. Duttargi², S. Moturi², K. Khan², J. Hawksworth², C. Matsumoto², T. Fishbein², A. Kroemer²
¹Walter Reed National Military Medical Center, Bethesda, MD, ²MedStar Georgetown Transplant Institute, Washington, DC
*Purpose: Despite profound advances in immunosuppression, intestinal transplantation (ITx) is plagued by frequent cellular rejection. T regulatory cells (Tregs) are key in mitigating immune cell…