2020 American Transplant Congress
Recipient Expression of C-Type Lectin Receptor Mincle Promotes Rapid T Cell Homeostatic Recovery Following Antibody Mediated Lymphoablation
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Antibody-mediated lymphocyte depletion is widely used in transplantation. We recently established that T cell recovery in mouse heart allograft recipients treated with anti-thymocyte globulin…2020 American Transplant Congress
Large Academic Center Experience with Treatment of Suspected/Confirmed Kidney Transplant Active Antibody Mediated Rejection
*Purpose: Therapeutic plasma exchange (TPE) and intravenous immunoglobulin (IVIG) are common active antibody mediated rejection (ABMR) treatments in kidney transplant recipients (KTRs), but with unclear…2020 American Transplant Congress
Development of Self-Limited Low-Level BK Viremia/Viruria Suggests Ideal Immunosuppression to Suppress T-Cell and Antibody-Mediated Rejection and to Preserve Kidney Allograft Function
University Hospital Zurich, Zurich, Switzerland
*Purpose: Polyomavirus BK (BKV) has been suggested as a surrogate marker of overimmunosuppression. Due to recent advances in monitoring strategies and pre-emptive therapy, progression to…2020 American Transplant Congress
Polyfunctional Cytokine Secreting Th17 Cells Preferentially Infiltrate Murine Renal Allografts with Acute Rejection and Are Associated with Elevated Th17: Treg Ratio
*Purpose: Our group has shown that renal transplant patients with acute rejection have elevated blood mRNA RORγt: FOXP3 ratio compared to patients with stable graft…2020 American Transplant Congress
The Evolution and Impact of ABMR Histology and Transplant Glomerulopathy in the Presence or Absence of HLA-DSA
*Purpose: After kidney transplantation, the occurrence of ABMRh (=histological picture of antibody-mediated rejection) and transplant glomerulopathy (cg) has been reported, both in the presence and…2020 American Transplant Congress
Immune Checkpoint Inhibitor Use in Kidney Transplant Recipients: Rejection Risk, Prevention and Transcriptional Signature in Allograft
1Brigham and Women's Hospital, Boston, MA, 2University of Alberta, Edmonton, AB, Canada
*Purpose: Immune checkpoint inhibitor (ICI) use has changed the landscape of cancer treatment. Several cases of acute rejection in use of ICI have been reported,…2020 American Transplant Congress
Simultaneously Detection of ddcfDNA in Plasma and Urine Assist to Determine the Type of Rejection in Renal Transplant Patients
*Purpose: The correct diagnosis and treatment of acute rejection (ABMR and TCMR) are the key to the long-term survival after renal transplantation. Renal biopsy is…2020 American Transplant Congress
Simultaneous Liver and Kidney Transplantation—The Lack of Influence of Pre-Formed DSA
Recanati-Miller Transplantation Institute, Mount Sinai Hospital, New York, New York, NY
*Purpose: It is known that renal transplant recipients with preformed donor specific antibodies (DSA) have poorer outcomes associated with episodes of acute rejection (AR) and…2020 American Transplant Congress
RNA Sequencing of Urine RNA Samples for Biomarker Discovery
*Purpose: An accurate, noninvasive assay based on urinary gene expression profiles would be a powerful tool for clinical management of kidney transplant patients. We have…2020 American Transplant Congress
Lims1 Gene and Risk of T-Cell Mediated Rejection in Kidney Transplant Recipients
*Purpose: Recent advances have provided new insights into the pathogenesis of kidney allograft rejection caused by additional antigens associated with genetic risk variant of LIM…
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