Articles tagged "Rejection"

2020 American Transplant Congress
Costimulation Blockade-Based Maintenance Immunosuppression in a Sensitized Nonhuman Primate Kidney Allotransplantation Model
R. Schmitz, Z. W. Fitch, P. M. Schroder, A. Y. Choi, M. Manook, J. Yoon, J. Kwun, S. J. Knechtle
Department of Surgery, Duke University Medical Center, Durham, NC
*Purpose: Sensitized transplant recipients represent a challenging population in part due to the presence of donor-specific antibodies (DSA), which increase the risk of antibody-mediated rejection.…
2020 American Transplant Congress
Can Cxcr3⁺Cd62l^–Cd4⁺ T Cells Serve as Early Warning Sentinels for Subclinical Rejections after Vascularized Composite Allotransplantation (vca)?
M. Kim¹, D. Fisher¹, J. Loo¹, J. Skitzki¹, E. Repasky²
¹Surgical Oncology, Roswell Park Comprehensive Cancer Center, Buffalo, NY, ²Immunology, Roswell Park Comprehensive Cancer Center, Buffalo, NY
*Purpose: New microsurgical techniques and powerful immunosuppressive drugs have made it possible for severely injured patients to receive VCA to replace limbs, hands, or faces,…
2020 American Transplant Congress
Comparison of Clinical Characteristics and Outcomes of Early Antibody-Mediated Rejection and Late Antibody-Mediated Rejection after Kidney Transplantation
G. Chen, Z. Wu, C. Wang, X. Liu, Q. Li, L. Chen
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China
*Purpose: Antibody-mediated rejection(AMR) is a major risk factor for graft loss after kidney transplantation. Some AMR appeared within 6 months after kidney transplant, that we…
2020 American Transplant Congress
Comparison of Reduced-Dose and Labeled-Dose Belatacept Conversion with Immediate or Early Tacrolimus Withdrawal in Kidney Transplant Recipients without Maintenance Corticosteroids
H. Kuzaro¹, A. R. Shields², M. Cuffy², E. S. Woodle¹, K. Pembaur², S. Safdar², S. Huang², G. Krisko², S. Raabe², R. Parks², J. Kremer²
¹U Cincinnati, Cincinnati, OH, ²The Christ Hospital, Cincinnati, OH
*Purpose: A primary reason for conversion from tacrolimus (TAC) to belatacept (BELA) is to avoid nephrotoxicity. Previous published experiences with BELA-conversion regimens have shown increased…
2020 American Transplant Congress
Proteomic Profiling of Circulating Extracellular Vesicles Isolated from Human Lung Transplant Recipients
S. Bansal¹, M. McGilvrey², K. Garcia-Mansfield², R. Sharma², R. Bremner¹, M. Smith¹, R. Hachem³, P. Pirrotte², T. Mohanakumar¹
¹Norton Thoracic Institute, St. Joseph’s Hospital and Medical Center, Phoenix, AZ, ²Translational Genomics Research Institute (TGen), Collaborative Center for Translational Mass Spectrometry (CCTMS), Phoenix, AZ, ³Department of Medicine, Washington University School of Medicine, Phoenix, AZ
*Purpose: Circulating exosomes in human lung transplant recipients (LTxRs) with acute (AR) and chronic rejection (bronchiolitis obliterans syndrome [BOS]) contain donor human leukocyte antigen (HLA)…
2020 American Transplant Congress
Thymoglobulin Dose and Incidence of Biopsy Proven Acute Rejections in the Early Post Transplant Period
K. Shimko, K. Schonder, D. Jorgensen, K. Kalra, A. Cherukuri, R. Mehta, I. Melgarejo, P. Sood, S. Hariharan, R. Mehta
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Optimal dosing of thymoglobulin (ATG) for induction has not been well defined. Our protocol aims for 5-6mg/kg cumulative dose divided over 4 doses. However,…
2020 American Transplant Congress
Molecular Diagnosis of Rejection in Liver Transplant Biopsies: The INTERLIVER Study
K. S. Madill-Thomsen¹, P. F. Halloran², .. The INTERLIVER Study Group³
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Alberta, Edmonton, AB, Canada, ³., ., AB, Canada
*Purpose: Diagnosing rejection in liver transplant biopsies is challenging given the limitations of histology e.g. low kappa values among pathologists. A Molecular Microscope® Diagnostic system…
2020 American Transplant Congress
Ion AmpliSeq RNA Expression Panel Evaluated by Next-Generation Sequencing (NGS) Can Detect Genes in Human Formalin-Fixed Paraffin-Embedded Kidney Biopsies to Predict T Cell and Antibody Mediated Rejection in Renal Allografts
P. Ruiz¹, E. Margolles-Clark¹, G. Guerra², A. Mattiazzi², M. Ortigosa-Goggins², G. Ciancio¹, L. Chen¹, G. Burke¹
¹Surgery, University of Miami, Miami, FL, ²University of Miami, Miami, FL
*Purpose: Optimization of effective anti-rejection therapies to prevent allograft rejection and to minimize drug toxicity may be aided by utilizing in situ biomarkers for detection…
2020 American Transplant Congress
Significance of DSA Clearance in Antibody Mediated Rejection in Pediatric Kidney Transplant Recipients on 1 Year Outcomes: Interim Results from PARAMOUr “Pediatric Renal AMr Outcomes” Study
I. Ashoor¹, R. Garro², S. Solomon³, A. Jain⁴, M. Kallash⁵, K. Twombley⁶
¹LSHUSC Children's Hospital New Orleans, New Orleans, LA, ²Emory University School of Medicine, Atlanta, GA, ³New York Medical College, Valhalla, NY, ⁴Wayne State University School of Medicine, Detroit, MI, ⁵Nation Wide Children's Hospital, Columbus, OH, ⁶Medical University of South Carolina, Charleston, SC
*Purpose: Little is known about how donor specific antibody (DSA) clearance correlates with outcomes in pediatric antibody mediated rejection (AMR). There is also little data…
2020 American Transplant Congress
Development and Impact of DSA after Lung Transplant
M. Henderson¹, G. Morris², C. Burt¹, A. Feist¹, J. Kozuch¹, E. Schonhoft³, G. Yung³, T. Floreth³, K. Afshar³, E. Golts⁴, M. Mariski¹
¹Pharmacy, University of California San Diego Health, San Diego, CA, ²Immunology, University of California San Diego Health, San Diego, CA, ³Pulmonology, University of California San Diego Health, San Diego, CA, ⁴Cardiothoracic Surgery, University of California San Diego Health, San Diego, CA
*Purpose: Antibody-mediated rejection (AMR) after lung transplant (LT) is a serious complication, potentially leading to graft failure despite advances in drug therapy. Diagnosis and treatment…