Articles tagged "Rejection"

2021 American Transplant Congress
Graft Outcomes of Antibody Mediated Rejection without Donor Specific Anti – HLA Antibodies After Kidney Transplantation
H. Ko, S. Min, A. Han, S. Ahn, C. T. Chung, H. Kim, K. Choi, S. Min, H. Kang, J. Ha
Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: The aim of this study was to investigate graft outcomes based on the presence of donor-specific anti-HLA antibodies (DSA) and the time of diagnosis…
2021 American Transplant Congress
Intermediate Outcomes Following Early Inflammatory Changes on Surveillance Biopsies
I. Melgarejo¹, V. Viswanathan², A. Sharma¹, P. Sood¹, C. Puttarajappa¹, N. Shah¹, M. Molinari¹, A. Tevar¹, C. Wu¹, S. Hariharan¹, R. Mehta¹
¹Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, ²Department of Renal-electrolyte, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: The implications on early inflammatory changes on surveillance biopsies on intermediate and long-term outcomes is unclear.*Methods: Of the 1000 kidney transplant (live donor and…
2021 American Transplant Congress
Induction Immunosuppression Efficacy in Pancreas and Kidney Transplantation in the SARS-CoV-2 Era
H. Sarumi, K. Vassar, S. Jackson, T. Pruett, R. Kandaswamy
University of Minnesota, Minneapolis, MN
*Purpose: Lymphocyte depleting induction is associated with increased risk of infection. Our institution adopted a stratified induction protocol with the intent to decrease risk for…
2021 American Transplant Congress
Simultaneous Pancreas-kidney Transplantation (spk) and, Simultaneous Deceased Donor Pancreas and Living Donor Kidney Transplantation (splk) in Diabetic Patients with End Stage Renal Disease
Y. Ko
Department of Surgery, Asan Medical Center, Seoul, Korea, Republic of
*Purpose: The purpose of this study is to compare clinical outcomes of simultaneous pancreas-kidney transplantation (SPK) and simultaneous deceased donor pancreas and living donor kidney…
2021 American Transplant Congress
Quilty Lesions are Associated with a Tolerance Profile in Heart Allografts Biopsies
J. Torrealba, S. Moore, S. Sathirareuangchai, L. De Las Casas, Q. Cai
Pathology, UTSW Medical Ctr, Dallas, TX
*Purpose: Previously, in 42 cardiac allograft biopsies, we demonstrated that the presence of Foxp3+ innate and TGF- β + adaptive regulatory lymphocytes in Quilty lesions…
2021 American Transplant Congress
Reducing Rejection in Pediatric Kidney Transplantation: The Improving Renal Outcomes Collaborative (iroc)
C. Varnell¹, A. Warmin¹, G. Barletta², C. Belsha³, L. Harshman⁴, D. Kershaw⁵, C. Pruette⁶, S. Ranabothu⁷, M. Seifert⁸, P. Singer⁹, M. Yanik¹⁰, K. Rich¹, A. Modi¹, D. Hooper¹
¹Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Phoenix Children’s Hospital, University of Arizona, Phoenix, AZ, ³SSM Health Cardinal Glennon Children's Hospital, St Louis, MO, ⁴University of Iowa Stead Family Children’s Hospital, Iowa City, IA, ⁵C.S. Mott Children’s Hospital, Ann Arbor, MI, ⁶Johns Hopkins University School of Medicine, Baltimore, MD, ⁷Arkansas Children’s Hospital, Little Rock, AR, ⁸University of Alabama at Birmingham, Children’s of Alabama, Birmingham, AL, ⁹Cohen Children's Hospital, Brooklyn, NY, ¹⁰Levine Children's Hospital, Charlotte, NC
*Purpose: To study the effect of implementing a Medication Adherence Promotion System (MAPS) on acute rejection (AR) rates in 9 pediatric kidney transplant (KT) programs.*Methods:…
2021 American Transplant Congress
Degree of T Cell Infiltration Predicts Treatment Response in Pediatric Liver Late Acute Cellular Rejection
M. Rogers, G. Begum, Q. Sun, A. Peters
Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: Late acute cellular rejection (ACR) occurs >6mo post-liver transplant and is associated with chronic rejection and allograft loss. Currently, no diagnostic features predict ACR…
2021 American Transplant Congress
Relationship Between %dd-cfDNA, MMDx Molecular Diagnoses, and Donor-specific Antibody in the Trifecta Study
P. F. Halloran¹, L. G. Hildago², J. Reeve¹, Z. Demko³, A. Prewett³, P. Billings³, J. Truong⁴, P. Vander Horn⁴, &. Trifecta Study Group⁵
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²University of Wisconsin, Madison, WI, ³Natera Inc., San Carlos, CA, ⁴One Lambda Inc., West Hills, CA, ⁵., ., AB, Canada
*Purpose: The Trifecta Study is a prospective multicenter investigator-initiated trial to evaluate the relationship between %dd-cfDNA and molecular biopsy findings at the time an indication…
2021 American Transplant Congress
Longitudinal Surveillance, Relative Change Value (RCV) Improve Diagnostic Test Accuracy (DTA) of Donor-Derived Cell Free DNA (dd-cfDNA)
S. Anand, F. Lopez-Verdugo, J. Sanchez-Garcia, L. Dong, M. Fife, J. Krong, D. Morris, T. Srinivas
Intermountain Medical Center, Murray, UT
*Purpose: dd-cfDNA, an injury biomarker in kidney transplant (KTx), is emerging as a trigger for biopsy (Bx) and superior to the traditional trigger of change…
2021 American Transplant Congress
Is Subclinical Allograft Rejection by 2019 Banff Criteria Associated with Worse Kidney Allograft Outcomes? Comparison Between 2007 and 2019 Banff Criteria
M. T. Victor¹, S. Park², K. Guo¹, L. Zhao¹, J. Friedewald³
¹Feinberg School of Medicine, Northwestern University, Chicago, IL, ²Transplant Nephrology, Northwestern Univeristy, Chicago, IL, ³Transplant Nephrology, Northwestern University, Chicago, IL
*Purpose: We hypothesize that Subclinical Acute Rejection (SubAR) under the new Banff 2019 criteria will be more strongly associated with a 2-year composite endpoint (2Y-CCE)…