2021 American Transplant Congress
A Comparative Analysis of Kidney Allograft Outcomes in Steroid Use versus Steroid Discontinuation After Basiliximab Induction: Unos Data Base Study
*Purpose: Basiliximab is a monoclonal antibody produced by recombinant DNA technology used by many transplant centers in the U.S. as induction immunosuppression. When Basiliximab is…2021 American Transplant Congress
The Clinical Significance of Preformed C1q-binding Donor-specific HLA Antibodies in Kidney Transplantation
*Purpose: Complement activation is one dominant mechanism which cause allograft injury in kidney transplantation (KT). Anti-HLA donor-specific antibodies (DSA) that bind to HLA molecules on…2021 American Transplant Congress
Early Reduction of Tacrolimus Trough Levels Improves Long-term Kidney Function without Increase in Incidence of Acr
*Purpose: We examined the impact of clinical practice management of tacrolimus trough levels in liver transplant recipients on kidney function and incidence of rejection in…2021 American Transplant Congress
The Impact of Tacrolimus IPV and TTR on the Development of De Novo Donor-specific Antibodies in Kidney Transplant Recipients
*Purpose: High intrapatient variability (IPV) and low time in therapeutic range (TTR) of tacrolimus (TAC) may increase the risk of developing de novo donor-specific antibodies…2021 American Transplant Congress
Leflunomide Therapy for Treatment of Bk Viremia in Pediatric Kidney Transplant Recipients
*Purpose: BK viremia (BKV) after kidney transplantation (KT) poses significant risk for BK virus-associated nephropathy (BKVN) and impacts graft survival. Conventional treatment involves reduction of…2021 American Transplant Congress
Worsening Impact of Acute Kidney Rejection on Long Term Graft Survival from 2000 to 2014
1Surgery, East Carolina University, Greenville, NC, 2Surgery, Duke University, Durham, NC
*Purpose: Acute rejection (AR) has been shown to impact graft survival after kidney transplant (KTx), however there is limited data on its impact on long…2021 American Transplant Congress
Inflammation in Scarred Cortex (i-IFTA) is Significantly Associated with T Cell-mediated Rejection (TCMR), but Not Antibody-mediated Rejection (ABMR), in Renal Allograft Biopsies (Bx)
Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: I-IFTA in renal allograft Bx has been found to be associated with decreased death-censored graft survival. Moderate to severe i-IFTA (2 or 3) is…2021 American Transplant Congress
A Comparison of Plasmapheresis Methods in the Treatment of Late Antibody Mediated Rejection
*Purpose: Effective management to prevent allograft loss after late antibody mediated rejection (ABMR) in kidney transplant (KTx) recipients remains a vexing clinical challenge. While plasma…2021 American Transplant Congress
Murine Cytomegalovirus Induces Kidney Allograft Injury via Th17 Cells Recruited by Both Viral Antigen-Specific and Cytokine/chemokine Mediated Pathways
*Purpose: Cytomegalovirus infection in transplant recipients has been associated with renal allograft rejection and graft failure. We have previously shown that murine CMV (MCMV) infected…2021 American Transplant Congress
Combined Donor Derived Cell Free DNA (AlloSure) and Peripheral Immune Cell Gene Expression (AlloMap) Testing for the Diagnosis of Rejection in Kidney Transplant Recipients with De Novo Donor Specific Antibodies
University of Wisconsin, Madison, WI
*Purpose: Combined donor-derived cell-free DNA (dd-cfDNA, AlloSure) and peripheral immune cell gene expression (AlloMap) may increase the predictive value of de novo DSA (dnDSA) for…
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