Articles tagged "Rejection"

2021 American Transplant Congress
Donor-Derived Cell-Free DNA as a Surrogate Marker for “Allograft Quiescence” After Kidney Transplantation
J. S. Bromberg¹, L. Bu², G. Gupta³, I. Moinuddin³, S. Anand⁴, A. Pai⁵, T. Alhamad⁶, V. Bowers⁷, S. Ghosh⁸, W. Tian⁸, E. Stites⁹
¹University of Maryland School of Medicine, Baltimore, MD, ²University of Minnesota, Minneapolis, MN, ³Virginia Commonwealth University, Richmond, VA, ⁴Intermountain Medical Center, Murray, UT, ⁵University of Texas McGovern Medical School, Houston, TX, ⁶Washington University in St. Louis, St. Louis, MO, ⁷Tampa General Hospital, Tampa, FL, ⁸CareDx, Brisbane, CA, ⁹University of Colorado, Aurora, CO
*Purpose: Donor-derived cell-free DNA (dd-cfDNA; AlloSure®) and the association with active rejection (AR) was described by Bloom et al, however subsequent insights have suggested this…
2021 American Transplant Congress
Donor Derived Cell-Free DNA (dd-cfDNA) in Pancreas Transplant Recipients
S. Riad¹, H. Sarumi², R. Kandaswamy³
¹Medicine, University of Minnesota, Minneapolis, MN, ²Surgery, University of Minnesota Physicians, Minneapolis, MN, ³Surgery, University of Minnesota, Minneapolis, MN
*Purpose: Data on the role of DD-cfDNA after pancreas transplantation is lacking. Herein we report on our center experience with DD-cfDNA in 10 unique SPK…
2021 American Transplant Congress
Steroid-free Immunosuppression in Heart-Kidney Transplant Patients: Is It Safe?
R. Skorka, J. Patel, M. Kittleson, N. Patel, T. Singer-Englar, A. Velleca, B. Azarbal, D. Chang, E. Kransdorf, L. Czer, D. Megna, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Simultaneous heart and kidney transplantation (sHKTx) has increased in numbers over the past 10 years. There are reports that the kidney protects the heart…
2021 American Transplant Congress
DSA is Associated with Molecular Changes in Many Hearts with Minor Abnormalities but Not Diagnosed as Antibody-Mediated Rejection
P. Halloran¹, K. S. Madill-Thomsen¹, &. the INTERHEART Study Group²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: We previously developed a microarray-based diagnostic system (MMDx) for heart transplant endomyocardial biopsies, measuring gene expression and interpreting antibody-mediated and T cell-mediated rejection (ABMR,…
2021 American Transplant Congress
The Effect of the Different Donor-Derived HLA T-Cell Epitope Targets on the Development of T Cell-Mediated Rejection After Kidney Transplantation
A. Senev, E. Van Loon, M. Emonds, M. Naesens
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: Many kidney allografts fail due to rejections caused by the donor and recipient HLA incompatibility. Recent studies have shown that HLA-DR and DQ mismatches…
2021 American Transplant Congress
Clinical Value of Surveillance Biopsies in Pediatric Liver Transplantation: A Single Center Experience with >800 Biopsies
B. Rocque¹, A. Zaldana¹, C. Weaver², J. Huang¹, A. Barbetta¹, V. Shakhin², C. Goldbeck¹, G. Yanni², R. Kohli², Y. Genyk¹, J. Emamaullee¹
¹Surgery, University of Southern California Keck School of Medicine, Los Angeles, CA, ²Pediatrics, Children’s Hospital-Los Angeles, Los Angeles, CA
*Purpose: While pediatric liver transplantation (LT) results in excellent long-term outcomes, a high incidence of early acute cellular rejection (ACR) and late graft fibrosis persists.…
2021 American Transplant Congress
Interruption of Notch Signaling via Blockade of Delta-Like Ligand 4 Prevents Co-Stimulation Blockade Resistant Allograft Rejection
A. J. Matar, B. P. Lovasik, Y. Dong, D. A. Faber, J. Habib, C. Breeden, J. Regenold, A. Ghosh, A. Stephenson, W. H. Kitchens, A. B. Adams
Emory University Department of Surgery, Atlanta, GA
*Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy with the advent of Belatacept, a novel CTLA4-Ig fusion protein that blocks CD28-mediated T…
2021 American Transplant Congress
Transforming Growth Factor-Beta Induced Myeloid-Derived Suppressor Cells Promote Transplant Immune Tolerance
F. Zhang
Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China, Beijing, China
*Purpose: Myeloid-derived suppressor cells (MDSCs) are a group of heterogeneous cells derived from bone marrow with immunosuppressive effect, which contribute to the establishment of transplant…
2021 American Transplant Congress
Donor Derived Cell-free-dna (dd-cfdna) as a Surrogate Marker for Kidney Biopsy- Indiana University Transplant Nephrology Experience
S. Valavoor¹, A. Sharfuddin², G. William³, M. Yaqub¹, D. Mishler¹, O. Adebiyi²
¹Nephrology, Indiana University, Indianapolis, IN, ²Transplant Nephrology, Indiana University, Indianapolis, IN, ³Transplant Surgery, Indiana University, Indianapolis, IN
*Purpose: Patient monitoring after kidney transplantation (KT) for early detection of allograft rejection remains key in preventing allograft loss. Donor-derived cell-free DNA (dd-cfDNA), a noninvasive…
2021 American Transplant Congress
Dosing Weight of Rabbit Antithymocyte Globulin and Outcomes Among Kidney Transplant Patients Treated for Rejection
C. Patton, K. Cunningham, C. D'Agostino, A. Novak, M. Kapugi, K. Lang, C. Kane
Pharmacy, Northwestern Memorial Hospital, Chicago, IL
*Purpose: Rabbit antithymocyte globulin (rATG) is FDA approved for kidney transplant induction therapy and treatment of T-cell mediated rejection (TCMR). While prior studies comparing dosing…