Articles tagged "Rejection"

2021 American Transplant Congress
Days of Delayed Graft Function and Its Impact on Graft Outcomes in Deceased Donor Kidney Transplant
P. Budhiraja¹, R. J. Butterfield², S. S. Misra¹, K. S. Reddy³, L. Kodali¹, H. A. Khamash¹, S. Nair¹, G. K. Mour¹, H. A. Chakkera¹, C. C. Jadlowiec³, H. Janna¹, R. L. Heilman¹
¹Department of Medicine, Mayo Clinic Arizona, Phoenix, AZ, ²Department of Statistics, Mayo Clinic Arizona, Phoenix, AZ, ³Department of Surgery, Mayo Clinic Arizona, Phoenix, AZ
*Purpose: There has been controversy regarding impact of delayed graft function (DGF) on risk of acute rejection and graft survival. This is likely due to…
2021 American Transplant Congress
Food Insecurity and Impact on Transplant Outcomes in Pediatric Kidney Transplant Recipients
A. Moin, P. Verghese, R. Engen, D. Matossian
Pediatric Nephrology, Lurie Children's Hospital, chicago, IL
*Purpose: Food insecurity (FI), defined as inconsistent access to food or worry over shortage of food that prevents an active and healthy life, has not…
2021 American Transplant Congress
The Summarized Assessment of Endothelin a Receptors Expression in Renal Transplant Compartments is Associated with Antibody Mediated Rejection
M. Banasik¹, K. Nowanska¹, P. Donizy², K. Koscielska-Kasprzak³, S. Zmonarski¹, M. Kuriata-Kordek¹, A. Tukiendorf⁴, A. Hałoń², D. Janczak⁵, M. Krajewska¹
¹Department of Nephrology and Transplantation Medicine, Wroclaw Medical University, Wroclaw, Poland, ²Department of Pathomorphology and Oncological Cytology, Wroclaw Medical University, Wroclaw, Poland, ³Research laboratory, Wroclaw Medical University, Wroclaw Medical University, Wroclaw, Poland, ⁴Department of Public Health, Wroclaw Medical University, Wroclaw, Poland, ⁵Department of General, Vascular and Transplant Surgery, Wroclaw Medical University, Wroclaw, Poland
*Purpose: The presence of non-HLA anti-endothelin A receptor antibodies may be important in transplant injury but the expression of the endothelin A receptor (ETA receptor)…
2021 American Transplant Congress
Pathology of the Explanted Lungs and Surveillance Allograft Biopsy in 202 Lung Transplant Cases: Single Institution Experience
S. Sathirareuangchai¹, S. Moore¹, Q. Cai¹, L. De Las Casas¹, J. Joerns², J. Torrealba¹
¹Pathology, University of Texas Southwestern Medical Center, Dallas, TX, ²Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX
*Purpose: This study correlates lung transplantation outcomes with pathologic diagnoses of explants and surveillance transbronchial allograft biopsies.*Methods: A retrospective IRB approved review of archival material…
2021 American Transplant Congress
Multiplexed Imaging Mass Cytometry of the Alloimmune Landscape of Rejection in Clinical Liver Transplantation
J. Emamaullee, N. Ung, C. Man, J. Hoeflich, C. Goldbeck, A. Barbetta, R. Sun, N. Matasci, J. Katz, J. Lee, S. Chopra, L. Sher, S. Asgharzadeh, O. Akbari, Y. Genyk
University of Southern California, Los Angeles, CA
*Purpose: Rejection continues to be an important cause of graft loss and failure post-liver transplant (LT). Imaging Mass Cytometry (IMC) is an emerging preclinical technique…
2021 American Transplant Congress
Assessment of Donor-Derived Cell-Free DNA Performance Characteristics Across the Spectrum of TCMR and ABMR After Kidney Transplant
L. Bu¹, S. Anand², A. Pai³, J. S. Bromberg⁴, T. Alhamad⁵, V. Bowers⁶, I. Moinuddin⁷, S. Ghosh⁸, W. Tian⁸, E. Stites⁹, G. Gupta⁷
¹University of Minnesota, Minneapolis, MN, ²Intermountain Medical Center, Murray, UT, ³University of Texas McGovern Medical School, Houston, TX, ⁴University of Maryland School of Medicine, Baltimore, MD, ⁵Washington University in St. Louis, St. Louis, MO, ⁶Tampa General Hospital, Tampa, FL, ⁷Virginia Commonwealth University, Richmond, VA, ⁸CareDx, Brisbane, CA, ⁹University of Colorado, Aurora, CO
*Purpose: Different donor-derived cell-free DNA (dd-cfDNA) thresholds have been reported in association with varying TCMR, ABMR and “Borderline” diagnoses. Interpretation of dd-cfDNA levels spanning active…
2021 American Transplant Congress
Evaluation of a Weight-Based Mycophenolate Mofetil Dosing Protocol for Kidney Transplant Maintenance Immunosuppression
M. Mahoney¹, E. Kincaide¹, J. Nelson¹, K. Klein¹, R. Hall¹, S. Bhayana²
¹University Health, San Antonio, Department of Pharmacotherapy and Pharmacy Services, The University of Texas at Austin, Pharmacotherapy Division, College of Pharmacy, San Antonio, TX, ²University Transplant Center, University Health, San Antonio, Department of Nephrology, The University of Texas Health Science Center at San Antonio, San Antonio, TX
*Purpose: To evaluate the safety and efficacy of a weight-based mycophenolate mofetil (MMF) dosing protocol in adult kidney transplant recipients (KTR).*Methods: This single-center retrospective study…
2021 American Transplant Congress
Prospective Intensive Monitoring for Anamnestic DSA Responses Allows Near Elimination of Early Clinical AMR
M. McGowan¹, A. Bickenbach¹, A. R. Shields², R. R. Alloway¹, P. Brailey¹, E. Portwood¹, C. Alquist¹, A. Christianson¹, B. Abu Jawdeh¹, M. Cuffy¹, J. Kremer², S. Bumb¹, A. Govil¹, M. Anand¹, T. Kaur¹, E. S. Woodle¹
¹U Cincinnati, Cincinnati, OH, ²Christ Hospital, Cincinnati, OH
*Purpose: Anamnestic donor specific antibody (aDSA) responses can result in severe, graft threatening antibody-mediated rejection (AMR). We hypothesized that intensive DSA monitoring (IDM) for aDSA…
2021 American Transplant Congress
CHBP Induces Stronger Immunosuppressive CD127⁺ M-MDSC via Erythropoietin Receptor
C. Yang
Urology, Zhongshan Hospital, Fudan University, Shanghai, China
*Purpose: Erythropoietin (EPO) is not only an erythropoiesis hormone, but also an immune regulatory cytokine. The receptors of EPO, (EPOR)2 and tissue protective receptor (TPR),…
2021 American Transplant Congress
Blood Gene Expression and Donor-derived Cell Free DNA for Diagnosing Subclinical Acute Rejection in Stable Kidney Transplant Recipients
S. Park¹, K. Guo², H. Raymond³, E. Poggio⁴, D. Taber⁵, C. Marsh⁶, S. Kurian⁷, S. Kleiboeker⁸, J. Weems⁸, J. Holman⁹, L. Zhao², R. Sinha⁸, S. Brietigam², C. Rebello², M. Abecassis¹⁰, J. Friedewald¹
¹Transplant Nephrology, Northwestern University, Chicago, IL, ²Feinberg School of Medicine, Northwestern University, Chicago, IL, ³Mayo Clinic College of Medicine and Science, Phoenix, AZ, ⁴Department of Nephrology and Hypertension, Cleveland Clinic, Cleveland, OH, ⁵Division of Transplant Surgery, Medical University of South Carolina, Charleston, SC, ⁶Department of Medicine and Surgery, Scripps Clinic and Green Hospital, La Jolla, CA, ⁷Scripps Health, La Jolla, CA, ⁸Eurofins US Clinical Diagnostics, Lee's Summit, MO, ⁹Transplant Genomics, Inc, Mansfield, MA, ¹⁰University of Arizona College of Medicine, Tucson, AZ
*Purpose: A blood gene expression profile (GEP) has been established as a non-invasive screen for subclinical acute rejection (subAR). For patients with allograft dysfunction, donor-derived…