Articles tagged "Rejection"

2021 American Transplant Congress
Titer Stability vs. Terminal Pre-transplant Titer: Titer History is Irrelevant for A₂ to B Transplantation
A. Gilbert¹, S. Radomski², J. Vucci¹, B. Thomas¹, M. Cooper¹
¹Medstar Georgetown Transplant Institute, Washington, DC, ²Johns Hopkins Medical Center, Baltimore, MD
*Purpose: Minor ABO incompatibile (ABOi) transplants from blood group A2 or A2B donors have increased since 2014, but initial guidance suggested that establishing an anti-A…
2021 American Transplant Congress
Longitudinal Studies of Blood Anellovirus DNA Prior to Acute Rejection or Major Infection Events in Pediatric Kidney Transplant Recipients (PKTx)
R. Dandamudi, H. Gu, C. Goss, H. Gula, K. Wylie, V. Dharnidharka
Washington University in St Louis, St. Louis, MO
*Purpose: Blood levels of the ubiquitous but non-pathogenic anellovirus (AnV) taxa have been postulated to represent a biomarker of the overall state of immunosuppression after…
2021 American Transplant Congress
Use of Donor-Derived Cell-Free DNA for Assessment of Allograft Rejection After Change in Maintenance Immunosuppression Regimens in the First Year Post Kidney Transplant
M. Walsh, V. Peev, L. Lineberger, M. Brokhof, N. Kenyon, N. Alvey
Rush University Medical Center, Chicago, IL
*Purpose: The purpose of this study was to investigate whether the use of donor-derived cell-free DNA (dd-cfDNA) is an effective screening tool for allograft rejection…
2021 American Transplant Congress
Antibody-mediated Rejection and Sponge Effect in a Redo Lung Transplant Recipient: A Case Report
A. Arjuna, M. T. Olson, S. Tokman, R. Walia, T. Mohanakumar, A. S. Hashimi, M. A. Smith, R. M. Bremner, A. Omar
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ
*Purpose: Antibody-mediated rejection (AMR) typically presents with elevated titers of circulating donor specific antibodies (DSA) and increased mean fluorescence intensity (MFI), a surrogate marker for…
2021 American Transplant Congress
Significance of Repeated 1r Rejections in Heart Transplantation
C. Hsueh¹, L. Wilson², L. Bow², L. Bellumkonda²
¹Yale New Haven Hospital, New Haven, CT, ²Yale University School of Medicine, New Haven, CT
*Purpose: 1R rejection is commonly seen in routine post-transplant biopsies. While presence of occasional 1R rejection is not considered to be detrimental, the significance of…
2021 American Transplant Congress
Donor-derived Cell-free DNA Distinguishes Acute Rejection from Other Causes of Graft Injury in Liver Transplant Recipients
J. Levitsky¹, M. Miller², R. Sinha², E. Bixler², A. Al-Turck², J. Weems², M. Altrich², S. Kleiboeker², M. Abecassis³
¹Gastroenterology & Hepatology; Comprehensive Transplant Center, Northwestern University, Chicago, IL, ²Viracor Eurofins, Lees Summit, MO, ³University of Arizona College of Medicine Tucson, Tucson, AZ
*Purpose: The donor derived cell-free DNA (ddcfDNA) has emerged as strong biomarker for allograft injury, where the fraction of ddcfDNA is reported to increase in…
2021 American Transplant Congress
Sequential Analysis of Renal Allograft Rejection at Single Cell Resolution
T. Shi¹, C. Castro-Rojas¹, A. Burg¹, K. Roskin¹, J. Rush², B. Haraldsson², A. Shields³, R. Alloway³, E. Woodle³, D. Hildeman¹
¹Immunobiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, ²Novartis Pharmaceuticals AG, Basel, Switzerland, ³University of Cincinnati Medical Center, Cincinnati, OH
*Purpose: Renal allograft anti-rejection therapies (corticosteroids (CCS) and anti-lymphocyte globulin) have been the primary treatment modalities for over six decades, yet little is known about…
2021 American Transplant Congress
Novel Mixed Lymphocyte Reaction Monitoring System That Predicts Chronic Antibody- Mediated Rejection in Kidney Transplant Recipients
N. Iwahara¹, K. Hotta¹, T. Tanabe¹, D. Iwami², Y. Takada³, H. Higuchi¹, H. Sasaki³, H. Harada³, N. Shinohara¹
¹Hokkaido Univercity, Sapporo, Japan, ²Jichi Medical University, Shimotsuke, Japan, ³Sapporo City General Hospital, Sapporo, Japan
*Purpose: Chronic active antibody-mediated rejection (CAAMR) induced by de novo donor-specific antibodies (DSA) is the main cause of graft loss in the long-term. Currently, there…
2021 American Transplant Congress
Donor Kidney-Resident Macrophages Promote Allograft Inflammation and CD8 T Cell Response Post-Transplantation
A. Dangi¹, S. Yu², I. Husain¹, R. Geesala¹, X. Luo¹
¹Nephrology, Medicine, Duke University, Durham, NC, ²Division of Organ Transplantation, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
*Purpose: Kidney-resident macrophages play important roles in maintaining normal kidney function and promoting prompt repair following kidney injuries. Nevertheless, their fate and role in kidney…
2021 American Transplant Congress
Comparison of Donor-derived Cell Free Dna Between Recipients with First Solitary Allograft and Regrafts
S. Paluri¹, S. Muthusamy¹, M. Shinbashi¹, G. Gupta¹, B. Dale², Z. Kashi³, P. Halloran⁴, D. Kumar¹
¹Virginia Commonwealth University, Richmond, VA, ²CareDx, Brisbane, CA, ³Kashi Clinical Laboratories, Portland, OR, ⁴ATAGC, Edmonton, AB, Canada
*Purpose: Donor derived-cell free DNA (dd-cfDNA) is a biomarker of immunological injury. Multiple studies have validated its utility in recipients of first solitary kidney transplants…