2021 American Transplant Congress
Outcomes of Deceased Donor Transplants with Donor Specific Antibodies Before and After the New Kidney Allocation System
Columbia University, New York, NY
*Purpose: KAS forced centers to list unacceptable HLA antigens. Some centers excluded antigens at any level of anti-HLA Ab. Our center only excluded antibodies posing…2021 American Transplant Congress
Longitudinal Studies of Blood Donor-derived Cell Free DNA (dd-cfDNA) Show Predictable Rise at Time of BK Viremia or Viruria in Pediatric Kidney Transplant Recipients (PKTx)
1Washington University in St Louis, St. Louis, MO, 2CareDx, Brisbane, CA
*Purpose: Blood levels of dd-cfDNA elevate in various forms of kidney transplant injury, most notably used for detecting potential acute rejection. A few adult studies,…2021 American Transplant Congress
Treatment and Outcomes of Kidney Transplant Recipients with C4d Negative Antibody Mediated Rejection
Rush University Medical Center, Chicago, IL
*Purpose: The purpose of this study is to describe and evaluate treatment practices and patient outcomes for kidney transplant recipients with presence of C4d negative…2021 American Transplant Congress
Application of Linear Discriminant Analysis (lda) to Differentiate Acute Rejection (ar) and Acute Dysfunction Non-Rejection (adnr) in Liver Transplant Recipients
*Purpose: Blood-based biomarkers distinguishing acute-rejection (AR) from other causes of graft dysfunction (acute dysfunction non-rejection (ADNR)) would have significant clinical applicability in liver transplant (LT)…2021 American Transplant Congress
Utilization of Donor-Derived Cell-Free DNA Testing in Kidney Transplantation: Do One Month Values Have Any Prognostic Significance?
Wake Forest Univ, Winston Salem, NC
*Purpose: Percutaneous renal allograft biopsy is the current gold standard for detecting acute rejection after kidney transplantation (KT). Noninvasive tests such as plasma-based donor-derived cell-free…2021 American Transplant Congress
Towards National Organ Sharing: Fair Distribution of Eplets in Canada
McGill University, Montreal, QC, Canada
*Purpose: Eplet matching is being promoted as a rational approach to prevent immune-mediated injuries in transplantation. We studied the frequencies of eplets in a Canadian…2021 American Transplant Congress
Contribution of T-bet Expressing CD27+ CD21- Activated Memory B Cells Poised for Plasma Cell Differentiation to Antibody-mediated Rejection of Kidney Transplants
*Purpose: Alloimmunity triggered by donor-specific antibodies (DSAs) and ensuing development of antibody-mediated rejection (ABMR) are detrimental to organ transplants. Yet, the cellular states underlying B…2021 American Transplant Congress
Beyond Microarrays: Insights from Ncounter Transcript Analysis of Routine Archival Kidney Allograft Biopsies
Massachusetts General Hospital, Boston, MA
*Purpose: Microarray mRNA analysis of renal allograft biopsies has discovered important insights, but has limitations as a practical clinical test. Here we evaluate a new…2021 American Transplant Congress
Urinary Exosomal Cystatin C and Lipopolysaccharide Binding Protein as Biomarkers for Monitoring Antibody-mediated Rejection After Kidney Transplantation
*Purpose: This study aims to discover and validate urinary exosomal biomarkers for antibody-mediated rejection (ABMR) after kidney transplantation.*Methods: A total of 60 urine samples from…2021 American Transplant Congress
The Assesment of Pre-transplant Donor-reactive IL-21 Producing T Cells as a Tool to Identify Patients at Risk for Acute Rejection
*Purpose: The measurement of panel-reactive antibodies (PRA) has proven valuable in the transplant setting but it does not account for the presence of donor-reactive memory…
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