Articles tagged "Rejection"

2021 American Transplant Congress
Utilization of Donor-Derived Cell-Free DNA Testing in Kidney Transplantation: Do One Month Values Have Any Prognostic Significance?
R. J. Stratta, A. Farney, J. Rogers, G. Orlando, A. Reeves-Daniel, A. Mena-Gutierrez, N. Sakhovskaya, C. Jay
Wake Forest Univ, Winston Salem, NC
*Purpose: Percutaneous renal allograft biopsy is the current gold standard for detecting acute rejection after kidney transplantation (KT). Noninvasive tests such as plasma-based donor-derived cell-free…
2021 American Transplant Congress
Towards National Organ Sharing: Fair Distribution of Eplets in Canada
S. Parto, B. Liu, W. Klement, S. Oikonomopoulos, I. Ragoussis, R. Sapir-Pichhadze
McGill University, Montreal, QC, Canada
*Purpose: Eplet matching is being promoted as a rational approach to prevent immune-mediated injuries in transplantation. We studied the frequencies of eplets in a Canadian…
2021 American Transplant Congress
Contribution of T-bet Expressing CD27+ CD21- Activated Memory B Cells Poised for Plasma Cell Differentiation to Antibody-mediated Rejection of Kidney Transplants
K. Louis¹, E. Bailly¹, C. Macedo¹, B. Ramaswami¹, X. Gu¹, G. Chalasani¹, A. Zeevi¹, P. Randhawa¹, H. Singh², C. Lefaucheur³, D. Metes¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Center for Systems immunology, Department of Immunology, University of Pittsburgh, Pittsburgh, PA, ³Human Immunology and Immunopathology, INSERM U976, Paris, France
*Purpose: Alloimmunity triggered by donor-specific antibodies (DSAs) and ensuing development of antibody-mediated rejection (ABMR) are detrimental to organ transplants. Yet, the cellular states underlying B…
2021 American Transplant Congress
Beyond Microarrays: Insights from Ncounter Transcript Analysis of Routine Archival Kidney Allograft Biopsies
I. Rosales, K. Tomaszewski, A. Milagros, T. Kawai, R. Smith, R. Colvin
Massachusetts General Hospital, Boston, MA
*Purpose: Microarray mRNA analysis of renal allograft biopsies has discovered important insights, but has limitations as a practical clinical test. Here we evaluate a new…
2021 American Transplant Congress
Urinary Exosomal Cystatin C and Lipopolysaccharide Binding Protein as Biomarkers for Monitoring Antibody-mediated Rejection After Kidney Transplantation
M. Kim, S. Lim, S. Shin
Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of
*Purpose: This study aims to discover and validate urinary exosomal biomarkers for antibody-mediated rejection (ABMR) after kidney transplantation.*Methods: A total of 60 urine samples from…
2021 American Transplant Congress
The Assesment of Pre-transplant Donor-reactive IL-21 Producing T Cells as a Tool to Identify Patients at Risk for Acute Rejection
A. Mendoza Rojas¹, T. van Gelder², R. de Kuiper¹, D. Reijerkerk¹, M. C. Clahsen-van Groningen³, D. A. Hesselink¹, C. C. Baan¹, N. M. van Besouw¹
¹Internal Medicine, Neprology & Transplantation, Erasmus Medical Center, Rotterdam, Netherlands, ²Department of Clinical Pharmacy & Toxicology, Leiden University Medical Center, Leiden, Netherlands, ³Internal Medicine, Pathology, Erasmus Medical Center, Rotterdam, Netherlands
*Purpose: The measurement of panel-reactive antibodies (PRA) has proven valuable in the transplant setting but it does not account for the presence of donor-reactive memory…
2021 American Transplant Congress
Titer Stability vs. Terminal Pre-transplant Titer: Titer History is Irrelevant for A₂ to B Transplantation
A. Gilbert¹, S. Radomski², J. Vucci¹, B. Thomas¹, M. Cooper¹
¹Medstar Georgetown Transplant Institute, Washington, DC, ²Johns Hopkins Medical Center, Baltimore, MD
*Purpose: Minor ABO incompatibile (ABOi) transplants from blood group A2 or A2B donors have increased since 2014, but initial guidance suggested that establishing an anti-A…
2021 American Transplant Congress
Longitudinal Studies of Blood Anellovirus DNA Prior to Acute Rejection or Major Infection Events in Pediatric Kidney Transplant Recipients (PKTx)
R. Dandamudi, H. Gu, C. Goss, H. Gula, K. Wylie, V. Dharnidharka
Washington University in St Louis, St. Louis, MO
*Purpose: Blood levels of the ubiquitous but non-pathogenic anellovirus (AnV) taxa have been postulated to represent a biomarker of the overall state of immunosuppression after…
2021 American Transplant Congress
Use of Donor-Derived Cell-Free DNA for Assessment of Allograft Rejection After Change in Maintenance Immunosuppression Regimens in the First Year Post Kidney Transplant
M. Walsh, V. Peev, L. Lineberger, M. Brokhof, N. Kenyon, N. Alvey
Rush University Medical Center, Chicago, IL
*Purpose: The purpose of this study was to investigate whether the use of donor-derived cell-free DNA (dd-cfDNA) is an effective screening tool for allograft rejection…
2021 American Transplant Congress
Antibody-mediated Rejection and Sponge Effect in a Redo Lung Transplant Recipient: A Case Report
A. Arjuna, M. T. Olson, S. Tokman, R. Walia, T. Mohanakumar, A. S. Hashimi, M. A. Smith, R. M. Bremner, A. Omar
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix, AZ
*Purpose: Antibody-mediated rejection (AMR) typically presents with elevated titers of circulating donor specific antibodies (DSA) and increased mean fluorescence intensity (MFI), a surrogate marker for…