Articles tagged "Rejection"

2021 American Transplant Congress
CD40 Blockade by the Fc-Silent Immunosuppressive Antibody Iscalimab Results in Diminished B Cell Activation and Differentiation and is Paralleled by Whole Blood Gene Expression Data
R. Kraaijeveld¹, M. W. van den Hoogen¹, A. E. de Weerd¹, E. Ferroro², G. Robert², U. Laessing², B. Haraldsson², J. S. Rush², C. C. Baan¹
¹Erasmus MC, Rotterdam, Netherlands, ²Novartis Pharmaceuticals AG, Basel, Switzerland
*Purpose: Blockade of costimulatory molecule CD40 by the Fc-silent immunosuppressive drug Iscalimab has shown to inhibit acute alloreactivity in non-human primates and is currently being…
2021 American Transplant Congress
CD56^dimCD16^bright NK Cells from Kidney Transplant Recipients with Antibody-mediated Rejection Display Increased Proliferation, Type-1 Activation and Cytotoxic Profile
E. Bailly¹, C. Macedo¹, K. Louis¹, B. Ramaswami¹, M. Lucas¹, C. Bentlejewski¹, P. Randhawa¹, A. Zeevi¹, C. Lefaucheur², D. Metes¹
¹Department of Surgery, Thomas E. Starzl Transplantation Institute, Pittsburgh, PA, ²INSERM UMR-S976. Endothelium, Inflammation & Alloreactivity, Université de Paris, Paris, France
*Purpose: CD56dimCD16bright NK cells are highly potent for cytotoxicity through cell-mediated cytotoxicity (CMC), antibody-dependent cell-mediated cytotoxicity (ADCC) and INF-γ production. The contribution of NK cells…
2021 American Transplant Congress
Naïve Rhesus Monkey CD4⁺CD8^loT Cells Comprise High Percentage of Memory T Cells with Strong Effector Function
M. Kubo, K. Sasaki, A. P. Gutiérrez, L. Lu, V. Vujevich, A. W. Thomson, M. Ezzelarab
Department of Surgery, University of Pittsburgh, PITTSBURGH, PA
*Purpose: Human CD4+CD8loT cells have been reported in patients with organ allograft rejection. We evaluated the incidence, phenotype, and function of CD4+CD8loT cells in nonhuman…
2021 American Transplant Congress
Does the Timing of Subclinical Acute Rejection After Kidney Transplant Matter?
P. Portocarrero¹, S. Park², K. Guo³, L. Zhao³, J. Friedewald²
¹Nephrology, Northwestern University, Chicago, IL, ²Transplant Nephrology, Northwestern University, Chicago, IL, ³Feinberg School of Medicine, Northwestern University, Chicago, IL
*Purpose: We hypothesized that the timing of subclinical acute rejection (subAR) diagnosed with biopsy, gene expression profile or donor-derived cell-free DNA is associated with poor…
2021 American Transplant Congress
Kidney Transplant Survival After Borderline Rejection in the Setting of Denovo Dsa Formation
A. P. Bregman¹, S. Jackson², S. Riad¹
¹Department of Nephrology, University of Minnesota, Minneapolis, MN, ²Biostatistics, M-Health Fairview Analytics, Minneapolis, MN
*Purpose: The significance of borderline cellular rejection has been questioned in the past. Data on borderline rejection with deNovo DSA (dnDSA) formation is limited. We…
2021 American Transplant Congress
Plasma Donor-Derived Cell-Free DNA Levels Risk-Stratify Kidney Allograft Injury with Isolated Transplant Glomerulitis
L. Bu¹, S. Anand², A. Pai³, J. S. Bromberg⁴, G. Gupta⁵, I. Moinuddin⁵, T. Alhamad⁶, V. Bowers⁷, S. Ghosh⁸, W. Tian⁸, E. Stites⁹
¹University of Minnesota, Minneapolis, MN, ²Intermountain Medical Center, Murray, UT, ³University of Texas McGovern Medical School, Houston, TX, ⁴University of Maryland School of Medicine, Baltimore, MD, ⁵Virginia Commonwealth University, Richmond, VA, ⁶Washington University in St. Louis, St. Louis, MO, ⁷Tampa General Hospital, Tampa, FL, ⁸CareDx, Brisbane, CA, ⁹University of Colorado, Aurora, CO
*Purpose: The Banff lesion Glomerulitis (g) characterizes the degree of microvascular glomerular inflammation. Some studies have demonstrated glomerulitis in the absence of C4d in association…
2021 American Transplant Congress
Treatment of Refractory Chronic Active Antibody-Mediated Rejection: Improvement in Histopathology are Delayed Compared to the Reduction in Donor Specific Antibodies
K. R. Degner¹, S. Parajuli¹, F. Aziz¹, N. Garg¹, M. Mohamed¹, D. A. Mandelbrot¹, S. E. Panzer¹, L. Hidalgo¹, N. A. Wilson¹, S. R. Reese¹, K. Van Hyfte¹, W. Zhong¹, P. Nickerson², A. Djamali¹
¹University of Wisconsin, Madison, WI, ²University of Manitoba, Winnipeg, MB, Canada
*Purpose: There are limited options for the treatment and management of refractory chronic active antibody-mediated rejection (cABMR) after kidney transplantation. Longitudinal histologic data in patients…
2021 American Transplant Congress
Quality Improvement Surveillance by Machine Learning
J. D. Perkins¹, E. Clemens², M. Granich³, J. Yeung³, J. Reyes¹
¹Surgery, University of Washington, Seattle, WA, ²Pharmacy, University of Washington, Seattle, WA, ³Center of Clinical Excellence, University of Washington, Seattle, WA
*Purpose: The purpose of this quality study was to compare our newly developed natural language processing (NLP) machine learning surveillance algorithm in detecting the rate…
2021 American Transplant Congress
Engineered Human Glomerular Endothelial Cells to Identify Non-hla Antibodies and Decipher Their Pathogenicity After Kidney Transplantation
B. Lamarthée¹, C. Burger¹, C. Leclaire¹, L. Morin¹, F. Terzi¹, C. Tinel¹, D. Anglicheau²
¹Inserm U1151, Necker-Enfants Malades Institute, PARIS, France, ²Necker Hospital, AP-HP, Department of Nephrology and Kidney Transplantation, PARIS, France
*Purpose: In kidney transplantation recipients (KTRs), donor-specific antibodies directed against Human Leucocyte Antigens (HLA-DSA) are thought to drive antibody-mediated rejection (AMR) and poor transplant outcome.…
2021 American Transplant Congress
Validation of a Novel Gene Expression Biomarker of Rejection Following Liver Transplantation
J. Levitsky¹, M. Kandpal¹, T. Whisenant², K. Guo¹, S. Kurian³, M. Abecassis⁴
¹Gastroenterology & Hepatology; Comprehensive Transplant Center, Northwestern University, Chicago, IL, ²University of California San Diego, San Diego, CA, ³Scripps Clinic, La Jolla, CA, ⁴University of Arizona College of Medicine Tucson, Tucson, AZ
*Purpose: Non-invasive biomarkers distinguishing early signs of immune activation vs. quiescence could more objectively guide immunosuppression management after liver transplantation (LT). Our aim was to…