2021 American Transplant Congress
Dna-pkcs Regulation of the Allogeneic Immune Response
University of Arkansas, Little Rock, AR
*Purpose: Organ transplantation is life-saving and continued investigations into immunological mechanisms that drive organ rejection are needed to improve immunosuppression therapies and prevent graft failure.…2021 American Transplant Congress
DSA Causes Mild Molecular ABMR-like Changes in Many Biopsies Not Diagnosed as Rejection
1Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, 2., ., AB, Canada
*Purpose: In the multicenter study INTERCOMEX, we developed a microarray-based system (MMDx) for diagnosing antibody-mediated and T cell-mediated rejection (ABMR, TCMR) in kidney transplant biopsies…2021 American Transplant Congress
Ectopic Hepatocyte Transplantation Into the Lymph Nodes in a Fully Mismatched Allogeneic Dog Model Using Tacrolimus and Prednisone
*Purpose: Develop organogenesis through ectopic hepatocyte transplantation (HT) into the upper abdominal lymph nodes (LN).*Methods: Three groups of Mongrel dogs weighting between 25-35 kg (control…2021 American Transplant Congress
RNA Sequencing (RNAseq) Tissue Analysis Can Provide Early Warning Signals for Potential Intestinal Transplant Complications
*Purpose: A disrupted mucosal barrier in intestinal grafts can cause alloreactive complications such as rejection, inflammation and infection following intestinal transplantation (ITx). We hypothesize that…2021 American Transplant Congress
Outcomes of Deceased Donor Transplants with Donor Specific Antibodies Before and After the New Kidney Allocation System
Columbia University, New York, NY
*Purpose: KAS forced centers to list unacceptable HLA antigens. Some centers excluded antigens at any level of anti-HLA Ab. Our center only excluded antibodies posing…2021 American Transplant Congress
Longitudinal Studies of Blood Donor-derived Cell Free DNA (dd-cfDNA) Show Predictable Rise at Time of BK Viremia or Viruria in Pediatric Kidney Transplant Recipients (PKTx)
1Washington University in St Louis, St. Louis, MO, 2CareDx, Brisbane, CA
*Purpose: Blood levels of dd-cfDNA elevate in various forms of kidney transplant injury, most notably used for detecting potential acute rejection. A few adult studies,…2021 American Transplant Congress
Treatment and Outcomes of Kidney Transplant Recipients with C4d Negative Antibody Mediated Rejection
Rush University Medical Center, Chicago, IL
*Purpose: The purpose of this study is to describe and evaluate treatment practices and patient outcomes for kidney transplant recipients with presence of C4d negative…2021 American Transplant Congress
Application of Linear Discriminant Analysis (lda) to Differentiate Acute Rejection (ar) and Acute Dysfunction Non-Rejection (adnr) in Liver Transplant Recipients
*Purpose: Blood-based biomarkers distinguishing acute-rejection (AR) from other causes of graft dysfunction (acute dysfunction non-rejection (ADNR)) would have significant clinical applicability in liver transplant (LT)…2021 American Transplant Congress
Utilization of Donor-Derived Cell-Free DNA Testing in Kidney Transplantation: Do One Month Values Have Any Prognostic Significance?
Wake Forest Univ, Winston Salem, NC
*Purpose: Percutaneous renal allograft biopsy is the current gold standard for detecting acute rejection after kidney transplantation (KT). Noninvasive tests such as plasma-based donor-derived cell-free…2021 American Transplant Congress
Towards National Organ Sharing: Fair Distribution of Eplets in Canada
McGill University, Montreal, QC, Canada
*Purpose: Eplet matching is being promoted as a rational approach to prevent immune-mediated injuries in transplantation. We studied the frequencies of eplets in a Canadian…
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