Articles tagged "Rejection"

2021 American Transplant Congress
Interruption of Notch Signaling via Blockade of Delta-Like Ligand 4 Prevents Co-Stimulation Blockade Resistant Allograft Rejection
A. J. Matar, B. P. Lovasik, Y. Dong, D. A. Faber, J. Habib, C. Breeden, J. Regenold, A. Ghosh, A. Stephenson, W. H. Kitchens, A. B. Adams
Emory University Department of Surgery, Atlanta, GA
*Purpose: Co-stimulation blockade (CoB) has emerged as a promising immunosuppression strategy with the advent of Belatacept, a novel CTLA4-Ig fusion protein that blocks CD28-mediated T…
2021 American Transplant Congress
Transforming Growth Factor-Beta Induced Myeloid-Derived Suppressor Cells Promote Transplant Immune Tolerance
F. Zhang
Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, Beijing, China, Beijing, China
*Purpose: Myeloid-derived suppressor cells (MDSCs) are a group of heterogeneous cells derived from bone marrow with immunosuppressive effect, which contribute to the establishment of transplant…
2021 American Transplant Congress
Donor Derived Cell-free-dna (dd-cfdna) as a Surrogate Marker for Kidney Biopsy- Indiana University Transplant Nephrology Experience
S. Valavoor¹, A. Sharfuddin², G. William³, M. Yaqub¹, D. Mishler¹, O. Adebiyi²
¹Nephrology, Indiana University, Indianapolis, IN, ²Transplant Nephrology, Indiana University, Indianapolis, IN, ³Transplant Surgery, Indiana University, Indianapolis, IN
*Purpose: Patient monitoring after kidney transplantation (KT) for early detection of allograft rejection remains key in preventing allograft loss. Donor-derived cell-free DNA (dd-cfDNA), a noninvasive…
2021 American Transplant Congress
Dosing Weight of Rabbit Antithymocyte Globulin and Outcomes Among Kidney Transplant Patients Treated for Rejection
C. Patton, K. Cunningham, C. D'Agostino, A. Novak, M. Kapugi, K. Lang, C. Kane
Pharmacy, Northwestern Memorial Hospital, Chicago, IL
*Purpose: Rabbit antithymocyte globulin (rATG) is FDA approved for kidney transplant induction therapy and treatment of T-cell mediated rejection (TCMR). While prior studies comparing dosing…
2021 American Transplant Congress
Graft Outcomes of Antibody Mediated Rejection without Donor Specific Anti – HLA Antibodies After Kidney Transplantation
H. Ko, S. Min, A. Han, S. Ahn, C. T. Chung, H. Kim, K. Choi, S. Min, H. Kang, J. Ha
Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: The aim of this study was to investigate graft outcomes based on the presence of donor-specific anti-HLA antibodies (DSA) and the time of diagnosis…
2021 American Transplant Congress
Intermediate Outcomes Following Early Inflammatory Changes on Surveillance Biopsies
I. Melgarejo¹, V. Viswanathan², A. Sharma¹, P. Sood¹, C. Puttarajappa¹, N. Shah¹, M. Molinari¹, A. Tevar¹, C. Wu¹, S. Hariharan¹, R. Mehta¹
¹Starzl Transplant Institute, University of Pittsburgh Medical Center, Pittsburgh, PA, ²Department of Renal-electrolyte, University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: The implications on early inflammatory changes on surveillance biopsies on intermediate and long-term outcomes is unclear.*Methods: Of the 1000 kidney transplant (live donor and…
2021 American Transplant Congress
Induction Immunosuppression Efficacy in Pancreas and Kidney Transplantation in the SARS-CoV-2 Era
H. Sarumi, K. Vassar, S. Jackson, T. Pruett, R. Kandaswamy
University of Minnesota, Minneapolis, MN
*Purpose: Lymphocyte depleting induction is associated with increased risk of infection. Our institution adopted a stratified induction protocol with the intent to decrease risk for…
2021 American Transplant Congress
Steroid-free Immunosuppression in Heart-Kidney Transplant Patients: Is It Safe?
R. Skorka, J. Patel, M. Kittleson, N. Patel, T. Singer-Englar, A. Velleca, B. Azarbal, D. Chang, E. Kransdorf, L. Czer, D. Megna, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Simultaneous heart and kidney transplantation (sHKTx) has increased in numbers over the past 10 years. There are reports that the kidney protects the heart…
2021 American Transplant Congress
DSA is Associated with Molecular Changes in Many Hearts with Minor Abnormalities but Not Diagnosed as Antibody-Mediated Rejection
P. Halloran¹, K. S. Madill-Thomsen¹, &. the INTERHEART Study Group²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: We previously developed a microarray-based diagnostic system (MMDx) for heart transplant endomyocardial biopsies, measuring gene expression and interpreting antibody-mediated and T cell-mediated rejection (ABMR,…
2021 American Transplant Congress
The Effect of the Different Donor-Derived HLA T-Cell Epitope Targets on the Development of T Cell-Mediated Rejection After Kidney Transplantation
A. Senev, E. Van Loon, M. Emonds, M. Naesens
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: Many kidney allografts fail due to rejections caused by the donor and recipient HLA incompatibility. Recent studies have shown that HLA-DR and DQ mismatches…