2021 American Transplant Congress
Dd-cfdna Can Guide Safe Reintroduction of Immunosuppression in Kidney Transplant Recipients with Covid-19
1CareDx, Brisbane, CA, 2Transplant Institute, NYU Langone Health, New York, NY
*Purpose: COVID-19 infection is associated with 25% mortality in kidney transplant recipients (KTRs). Reduction of anti-metabolite immunosuppressants during the acute COVID-19 illness is a common…2021 American Transplant Congress
Single Cell Rna-Sequencing of Urinary Cells and Defining the Immune Landscape of Rejection in Human Kidney Allografts
*Purpose: Transcriptome-based clustering of urinary cells in kidney transplant recipients may help identify cell-type specific injury and develop cell-type specific biomarkers for the noninvasive assessment…2021 American Transplant Congress
Development of a Rat Model of Antibody-Mediated Rejection After Liver Transplantation
*Purpose: Antibody-mediated rejection (AMR) is a refractory rejection after donor-specific antibody (DSA)-positive or ABO blood-type incompatible liver transplantation (LT), due at least in part to…2021 American Transplant Congress
A Reliable Non Invasive Alternative to Surveillance Renal Allograft Biopsy
Transplant Nephrology, University of Alabama Birmingham, Birmingham, AL
*Purpose:Surveillance Renal Allograft Biopsy (SAVB) is the standard of care to identify subclinical immunological injury(SCI). However fewer than 25% of transplant centers in the US…2021 American Transplant Congress
Infection Rates in Heart Transplant Recipients With Combined Tacrolimus and Sirolimus at High versus Low Concentrations
Loyola University Medical Center, Maywood, IL
*Purpose: Assess the impact of tacrolimus-sirolimus (TAC/SRL) concentration on infection rate in heart transplant recipients (HTR).*Methods: A retrospective review of HTR on TAC/SRL for ≥…2021 American Transplant Congress
The Use of Donor Derived Cell Free DNA in Children to Monitor Therapy of Kidney Rejection
Oregon Health & Science Univ, Portland, OR
*Purpose: Elevated donor-derived cell-free DNA (dd-cfDNA) in the presence of HLA donor-specific antibodies (DSA) are shown to correlate with acute antibody-mediated rejection (AMR) in adult…2021 American Transplant Congress
De Novo Membranous Nephropathy Associated with Antibody-mediated Rejection in Renal Transplant Recipients
*Purpose: Membranous nephropathy (MN) is a rare autoimmune disease, with the potential to develop a persistent nephrotic syndrome and end-stage chronic renal disease in some…2021 American Transplant Congress
Post Pediatric Liver Transplant Immunosuppression: What’s the Caregivers’ Perspective?
*Purpose: For children with liver transplants (LT), achieving an “ideal outcome” is a balancing act: too little immunosuppression (IS) begets graft injury; too much IS…2021 American Transplant Congress
Peripheral Blood Inflammatory Chemokines Uncover Rejection in the Absence of Histological Lesions
*Purpose: Cytokines and chemokines play a critical role in the pathophysiology of allograft rejection, but the relation of peripheral blood cytokine expression profiles to clinical…2021 American Transplant Congress
The Impact of De Novo Dose-Adjustment Strategies with Tacrolimus XR (LCP-Tac) in Kidney Transplant Recipients
Medical University of South Carolina, Charleston, SC
*Purpose: LCP-Tac is a once daily formulation of tacrolimus indicated for the prophylaxis of rejection in de novo kidney transplant recipients. It provides less variable…
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