Articles tagged "Rejection"

2021 American Transplant Congress
Reassessing TCMR in Kidney Transplant Indication Biopsies: Emerging Evidence for Partial Exhaustion in Late TCMR
P. Halloran¹, J. Reeve¹, &. the INTERCOMEX Study Group²
¹Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ²., ., AB, Canada
*Purpose: We rederived the MMDx rejection archetypes in an expanded set of 1679 kidney transplant biopsies to add power and potentially define heterogeneity in TCMR.…
2021 American Transplant Congress
Single-Cell RNA-seq Identifies Intra-Graft Population Heterogeneity in Acute Heart Allograft Rejection in the Mouse
C. Wu¹, Y. Tang¹, X. Shi¹, X. He¹, X. Li²
¹The First Affiliated Hospital,Sun Yat-sen University, Guangzhou, China, ²Immunobiology & Transplant Sciences Houston Methodist Hospital, Houston, TX
*Purpose: Transplant rejection remains a major barrier to graft survival and involves a diversity of cell types. But the heterogeneity in a given cell type…
2021 American Transplant Congress
Athena – Effect of Primary Immunosuppression on Development of De Novo Donor Specific Antibodies within First Year After Kidney Transplantation
W. Arns¹, A. Philippe¹, V. Ditt¹, I. A. Hauser¹, F. Thaiss¹, C. Sommerer¹, B. Suwelack¹, A. Finkel², C. Schiedel², D. Dragun¹, B. Nashan¹
¹ATHENA, Study Group, Germany, ²Novartis Pharma GmbH, Nuremberg, Germany
*Purpose: The ATHENA trial [NCT01843348] investigated safety and efficacy of everolimus combined with cyclosporine A [EVR/CsA] or tacrolimus [EVR/TAC] vs. tacrolimus plus mycophenolic acid [MPA/TAC]…
2021 American Transplant Congress
Single Center Experience Comparing Two Clinically Available Donor Derived Cell Free DNA Tests
S. Bunnapradist¹, S. Lee², P. Homkrailas³, G. Danovitch³
¹UCLA, Los Angeles, CA, ²Pharmacy, David Geffen School of Medicine at UCLA, Los Angeles, CA, ³David Geffen School of Medicine at UCLA, Los Angeles, CA
*Purpose: Donor derived cell-free DNA (dd cf-DNA), this new technology allows for non-invasive monitoring of graft function. Two most commonly used assays are Prospera (Natera®,…
2021 American Transplant Congress
Torque Teno Virus Load Predicts Allograft Rejection but Not Viral Infection After Kidney Transplantation; A Cohort Joint Modelling Study
A. L. van Rijn¹, H. F. Wunderink², I. A. Sidorov¹, C. S. de Brouwer¹, A. C. Kroes¹, H. Putter³, A. P. de Vries⁴, J. I. Rotmans⁴, M. C. Feltkamp¹
¹Medical Microbiology, Leiden University Medical Center, Leiden, Netherlands, ²Medical Microbiology, University Medical Center Utrecht, Utrecht, Netherlands, ³Medical Statistics, Leiden University Medical Center, Leiden, Netherlands, ⁴Internal Medicine, Leiden University Medical Center, Leiden, Netherlands
*Purpose: The main challenge of immunosuppressive therapy after solid organ transplantation is to find the optimal dose regimen, and prevent allograft rejection as well as…
2021 American Transplant Congress
Desensitization with Plasmapheresis and IV Immunoglobulin is Safe and Effective in Pra Positive Kidney Transplant Recipient Candidates in Covid-19 Pandemic Period
B. Sayin¹, A. Akdur², E. Karakaya², U. Musabak³, T. Colak¹, M. Haberal²
¹Department of Nephrology, Baskent University, Ankara, Turkey, ²Division of Transplantation, Department of General Surgery, Baskent University, Ankara, Turkey, ³Department of Immunology, Baskent University, Ankara, Turkey
*Purpose: High panel reactive antibody (PRA) levels may limit living-donor kidney transplantation (LDKT) according to increased risk of antibody mediated rejection. Desensitization may provide better…
2021 American Transplant Congress
The Clinical Significance of Preformed Anti-HLA-DQ Donor-specific Antibodies on Allograft Outcomes in Kidney Transplantation
S. Lee¹, C. Yang², B. Chung²
¹Seoul National University Hospital, Seoul, Korea, Republic of, ²Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea, Republic of
*Purpose: De-novo anti-HLA-DQ donor-specific antibody (DSA) has been identified as a risk factor for late graft dysfunction and graft loss in kidney transplantation (KT). The…
2021 American Transplant Congress
Impact of Social Support, Social Circumstances and Distance from Transplant Center on Post Liver Transplant Outcomes: An Analysis from a Predominantly Rural U.S. Cohort
R. Kaur¹, C. Lavender¹, E. Askew¹, S. Jafri², R. Thandassery¹, M. Deneke¹
¹University of Arkansas for Medical Sciences, Little Rock, AR, ²Henry Ford Hospital, Detroit, MI
*Purpose: Social support and social circumstances (SSSC) are critical yet less described entities in post-orthotopic liver transplant (OLT). We aimed to describe SSSC and correlate…
2021 American Transplant Congress
Donor Derived Cell Free DNA Identifies Rejection in Simultaneous Pancreas Kidney Transplant Recipients
M. Williams¹, S. Ghosh², L. L. Jenkins², M. Hertl¹, S. Saltzberg³, V. Peev³, E. Chan¹, E. Hollinger¹, E. Schadde¹, O. Olaitan¹
¹Department of Surgery, Rush University Medical Center, Chicago, IL, ²CareDx, Inc., Brisbane, CA, ³Department of Internal Medicine, Rush University Medical Center, Chicago, IL
*Purpose: Increased level of donor-derived cell-free DNA (dd-cfDNA) has proven to be a sensitive marker for allograft rejection after solid organ transplant, particularly heart and…
2021 American Transplant Congress
Long Term Safety and Efficacy of Tocilizumab (anti-il6r, Tcz) Therapy in the Treatment of Refractory Chronic Antibody Mediated Rejection (cabmr) in 25 Pediatric Renal Transplant Recipients
M. Pearl¹, P. Weng¹, A. Dokras², H. Pizzo³, J. Garrison³, C. Butler¹, J. Q. Zhang¹, K. Lim³, E. Reed¹, I. Kim³, M. Haas³, X. Zhang³, R. Ettenger¹, S. Jordan³, D. Puliyanda³
¹Pediatric Nephrology, UCLA Medical Center, Los Angeles, CA, ²Pediatric Nephrology, UT South Western, Dallas, CA, ³Pediatric Nephrology, Cedars Sinai Medical Center, West Hollywood, CA
*Purpose: Development of de novo donor specific antibodies (DSA) post renal transplantation puts pediatric patients at risk for chronic Antibody Mediated Rejection (cABMR) and allograft…