Articles tagged "Rejection"

2022 American Transplant Congress
M1 Macrophage Polarization in Antibody-Mediated Rejection After Renal Transplantation and the Intervention Study of Iguratimod
M. Zheng¹, W. Zijie², Z. Gui³, R. Tan¹, M. Gu³
¹Department of Urology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China, ²Jiangsu Province Hospital, Nanjing, China, ³Department of Urology, The Second Affiliated Hospital with Nanjing Medical University, Nanjing, China
*Purpose: After kidney transplantation, Antibody Mediated Rejection (ABMR) is the main factor affecting the long-term survival of kidney transplantation. Previous studies have confirmed that macrophage…
2022 American Transplant Congress
Monitoring Efficacy of Tocilizumab Treatment for Chronic Antibody Mediated Rejection (cAMR) in Kidney Transplants Using Donor-Derived Cell-Free DNA (dd-cf-DNA)
J. Tang¹, A. Vo¹, E. Huang¹, X. Zhang², N. Ammerman¹, A. Peng¹, R. Najjar¹, S. Sethi¹, K. Lim¹, M. Gillespie¹, N. Badash¹, S. Jordan¹
¹Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA, ²HLA Laboratory, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: IL-6/IL-6R have emerged as important targets for treating cAMR. Recent data show that long-term treatment can stabilize eGFR, reduce DSAs and result in a…
2022 American Transplant Congress
Donor Genetic Background Predisposes Differentiation and Accumulation of Regulatory T Cells in the Kidney Allografts
X. Lai¹, J. Wang¹, S. Han¹, C. Chunlei¹, L. VanOsdol¹, L. Gallon², J. Leventhal², M. Kandpal¹, Z. Zhang¹
¹Comprehensive Transplant Center, Microsurgery core, Northwestern University Feinberg School of Medicine, Chicago, IL, ²Surgery, Northwestern University Feinberg School of Medicine, Chicago, IL
*Purpose: We have previously demonstrated that donor kidney-intrinsic innate immunity determines the severity of delayed graft function (DGF) in kidney transplantation and potentiates long kidney…
2022 American Transplant Congress
Role of Innate Immunity in Regulating Host Responses to Ischemia and Reperfusion and Allograft Rejection Injury in Vascularized Composite Allotransplantation
S. Han¹, X. Lai², J. Wang¹, L. VanOsdol³, C. Chen¹, J. Mathew¹, J. R. Leventhal⁴, Z. Zhang⁵
¹Northwestern University, Chicago, IL, ²Comprehensive Transplant Center, Microsurgery Core, Northwestern University, Chicago, IL, ³Comprehensive Transplant Center, Northwestern University, Chicago, IL, ⁴Surgery, Northwestern Medicine, Chicago, IL, ⁵Northwestern University Transplant Surgery, Chicago, IL
*Purpose: Vascularized composite tissue allotransplantation (VCA) 's wide application has been impeded by deleterious side-effect of current immunosuppressive regimens. This study is aimed to determine…
2022 American Transplant Congress
Rejection After Liver Transplantation: What Can We Learn from Transcriptomic Analysis?
H. J. Braun¹, D. Amara², A. Zarinsefat¹, G. Szabo¹, Z. Laszik¹, P. Stock¹, N. Ascher¹
¹University of California, San Francisco, San Francisco, CA, ²UCLA, Los Angeles, CA
*Purpose: Acute cellular rejection (ACR) can occur at any time following liver transplantation (LT); initial ACR within 6 months is most common and occurs in…
2022 American Transplant Congress
Diagnostic Performance of Donor-Derived Cell-Free DNA Assay (AlloSure®) in Kidney Transplant Recipients with Graft Dysfunction: A Single Center Study
M. S. Naseer¹, H. Shokouh-Amiri², T. Creamer¹, R. McMillan², S. Tandukar¹, D. Aultman¹, G. B. Zibari¹, N. Singh¹
¹Transplant, John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA, ²John C. McDonald Regional Transplant Center - Willis Knighton Health System, Shreveport, LA
*Purpose: Circulating donor-derived cell-free DNA (dd-cf-DNA) is a non-invasive biomarker of kidney allograft injury with a high negative predictive value for ruling out active rejection…
2022 American Transplant Congress
Utility of Donor Derived Cell-Free DNA in Liver Transplantation
A. Zarrinpar, D. Lewis, C. Warren, S. Duarte
Surgery, University of Florida, Gainesville, FL
*Purpose: As a non-invasive measure of allograft injury, quantifying the fraction of donor-derived cell-free DNA (dd-cfDNA) has proven to be useful technique in kidney transplantation.…
2022 American Transplant Congress
Trends in Donor Derived Cell Free DNA Before and After Cellular and Antibody Mediated Rejection
K. Guo¹, J. Friedewald¹, C. Rebello¹, B. Kinsella¹, S. Park², L. Zhao¹
¹Northwestern University, Chicago, IL, ²Transplant nephrology, Northwestern University, Chicago, IL
*Purpose: The TRAC dd-cfDNA test was developed to detect acute kidney transplant rejection but can also detect subclinical rejection with improved performance in antibody-mediated rejection…
2021 American Transplant Congress
The Role of Donor-derived Cell-free DNA Testing in Detecting Subclinical Kidney Allograft Rejection
M. Dasari¹, J. Hendele², L. Sibulesky², N. Leca³
¹Department of Surgery, University of Washington, Seattle, WA, ²Department of Surgery, Division of Transplant, University of Washington, Seattle, WA, ³Department of Nephrology, UW Medicine Kidney and Pancreas Transplantation Program, University of Washington, Seattle, WA
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) testing is an emerging method of non-invasive testing for graft rejection in the field of solid-organ transplantation. We describe how…
2021 American Transplant Congress
Psmp is Discriminative for Chronic Active Antibody-Mediated Rejection and Predicts Graft Risk After Kidney Transplantation
Y. Fu, P. Zhan
Tianjin First Central Hospital, Tianjin, China
*Purpose: Chronic active antibody-mediated rejection (c-aABMR) is an intermediate process in the development of chronic antibody-mediated rejection (c-ABMR), a key problem in the long-term failure…