Articles tagged "Rejection"

2022 American Transplant Congress
Longitudinal Analysis of the Gut Microbiota Structure and Function After Renal Transplantation
A. Vaitkute¹, F. Yuen Chang¹, A. Greco², S. Chong¹, H. Mahdi³, M. Bajaj-Elliott², A. Pesenacker¹, R. Motallebzadeh¹
¹Institute of Immunity and Transplantation, UCL, London, United Kingdom, ²Institute of Child Health, UCL, London, United Kingdom, ³Department of Renal Medicine, UCL, London, United Kingdom
*Purpose: Despite marked improvements in outcomes after renal transplantation, graft loss from alloimmune pathology and adverse side effects including urinary tract infections and diarrhoea remain…
2022 American Transplant Congress
Single Dose Alemtuzemab Provides Comparable Rejection Free and Infection Free Survival Compared to Double Dose Alemtuzumab. In Comparison to Alemtuzemab, Basiliximab Has Superior Infection Free Graft Survival. Results from a Steroid Sparing Transplant Group
H. Sharma, A. Odugoudar, B. Devkaran, A. Rao, A. El-Bakry, T. Gunawardhane, D. Ridgway, M. Howse, S. Mehra
Department of Transplant Surgery, Royal Liverpool University Hospital, Liverpool, United Kingdom
*Purpose: The present study investigated the short-term biopsy-proven acute rejection rates and viral infection rates amongst our protocol of single-dose Alemtuzemab (Cohort 1) versus double…
2022 American Transplant Congress
Ixazomib for Desensitization (IXADES): Results of a Phase II Clinical Trial
N. Wilson¹, S. R. Reese², L. Ptak³, F. Aziz², S. Parajuli², V. Jucaud⁴, S. Denham⁴, A. Mishra⁵, P. Hematti⁵, A. Djamali²
¹University of Wisconsin, Madison, WI, ²Medicine, University of Wisconsin, Madison, WI, ³Administration, University of Wisconsin, Madison, WI, ⁴Terasaki Institute, Los Angeles, CA, ⁵UW Comprehensive Cancer Center, University of Wisconsin, Madison, WI
*Purpose: Ixazomib is a second-generation oral proteasome inhibitor, FDA approved for the treatment of refractory multiple myeloma. The purpose of the study was (1) to…
2022 American Transplant Congress
Spatially Resolved Molecular Profiling of Endothelial Cells in Antibody-Mediated Kidney Transplant Rejection
M. Melendez-Ferro, D. R. Kelly, M. E. Seifert
UAB School of Medicine, Birmingham, AL
*Purpose: Endothelial cells are key targets of alloimmune injury in antibody-mediated rejection (ABMR), but are challenging to study in situ using high-throughput methods. We aimed…
2022 American Transplant Congress
Wide Spectrum of Molecular Injury Highlights Heterogeneity of Banff Tubulitis and Interstitial Inflammation Lesions
M. J. Ellis¹, T. Maw², E. Huang³, E. Stites⁴, F. Shihab⁵, D. C. Brennan⁶, G. Shekhtman⁷, N. Agrawal⁷, J. Zeng⁷, S. Kung⁸
¹Duke University, Durham, NC, ²University of Southern California, Los Angeles, CA, ³Cedars-Sinai Medical Center, Los Angeles, CA, ⁴University of Colorado, Aurora, CO, ⁵University of Utah, Salt Lake City, UT, ⁶Johns Hopkins School of Medicine, Baltimore, MD, ⁷CareDx, Brisbane, CA, ⁸University of California, San Francisco, San Francisco, CA
*Purpose: The pathological definition and clinical significance of borderline T cell-mediated rejection (BL-TCMR) remains an area of active debate, leading to inconsistencies in therapeutic strategy.…
2022 American Transplant Congress
Comparative Case Study of Mycobacterium Infections in Pediatric Post Intestinal Transplant
S. Yerina¹, R. Kanthula¹, Y. Rekhtman², S. Kaufman¹, U. Ekong¹, N. Yazigi¹, T. Fishbein¹, A. Kroemer¹, C. Matsumoto¹, K. Khan¹
¹Transplant, Georgetown University Hospital, Washington, DC, ²GI and Nutrition, Prisma Health Midlands Children's Hospital, Columbia, SC
*Purpose: We describe two rare and challenging post pediatric intestinal transplant cases with both Mycobacterium (M) Abscessus and Mycobacterium (M) Immunogenum in post surgical site…
2022 American Transplant Congress
A Novel, High Throughput Droplet Digital PCR-Based Indel Quantification Method for the Detection of Circulating Donor-Derived Cell-Free DNA After Kidney Transplantation
J. G. Verhoeven¹, K. Boer¹, A. M. Peeters¹, M. C. Clahsen-van Groningen², J. I. Roodnat¹, J. van de Wetering¹, D. Nieboer³, D. A. Bost⁴, C. C. Baan¹, D. A. Hesselink¹
¹Department of Internal Medicine, Erasmus MC Transplant Institute, Rotterdam, Netherlands, ²Department of Pathology, University Medical Center Rotterdam, Rotterdam, Netherlands, ³Department of Public Health, University Medical Center Rotterdam, Rotterdam, Netherlands, ⁴JETA Molecular, Utrecht, Netherlands
*Purpose: Donor-derived cell-free DNA (ddcfDNA) is a promising minimally invasive biomarker for acute rejection (AR) in kidney transplant recipients. To assess the diagnostic value of…
2022 American Transplant Congress
Donor-Derived Cell-Free DNA and Gene Expression Profiling for Surveillance of Renal Allograft Injury and Rejection
A. N. Carrier, A. Crane, M. Pinedo, A. Bartosic, A. Haririan, J. R. Scalea, M. R. Weir, J. S. Bromberg
University of Maryland, Baltimore, MD
*Purpose: Donor derived cell free DNA (dd-cfDNA) and gene expression profiling offer non-invasive methods of early detection of graft injury and rejection in solid organ…
2022 American Transplant Congress
Tissue Engineering Scaffolds for Minimally Invasive Immunosurveillance of Acute Cellular Graft Rejection
R. R. Urie¹, D. Farris², A. Morris¹, E. Lombard¹, J. Z. Li³, D. Goldstein², L. Shea¹
¹Biomedical Engineering, University of Michigan, Ann Arbor, MI, ²Internal Medicine, University of Michigan, Ann Arbor, MI, ³Human Genetics, University of Michigan, Ann Arbor, MI
*Purpose: As there is no assay to predict the risk of acute cellular allograft rejection (ACAR), clinicians rely on protocol graft biopsy and aggressive, one-size-fits-all…
2022 American Transplant Congress
Urine-based Assay For Detection Of Acute Rejection In Pediatric Kidney Transplant Recipients
C. Crane¹, K. Zeeb², E. Phebus², C. Benavides², W. Wong³, E. Ingulli²
¹UCSD/Rady Children's Hospital, San Diego, CA, ²UCSD Rady Children's Hospital, San Diego, CA, ³Massachusetts General Brigham, Boston, MA
*Purpose: Biomarkers such as donor-derived cell free DNA (cfDNA) and gene expression profiling are utilized in adult transplant patients (pts), but these tests lack sensitivity…