Articles tagged "Rejection"

2022 American Transplant Congress
Kidney Allograft Injury is Reflected in the DNA Cargo of Urinary Extracellular Vesicles
I. Sedej¹, M. Štalekar², M. Tušek Žnidarič², K. Goričar³, N. Kojc⁴, P. Kogovšek², V. Dolžan³, M. Lenassi³, M. Arnol¹
¹Department of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia, ²Department of Biotechnology and Systems Biology, National Institute of Biology, Ljubljana, Slovenia, ³Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia, ⁴Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia
*Purpose: Following cell injury, donor-derived cell-free DNA (ddcfDNA) is increased in the urine of kidney transplant recipients. DNA containing urinary extracellular vesicles (uEVs) are relevant…
2022 American Transplant Congress
Leveraging Single-Cell Signatures in Kidney Transplant Biopsies Uncovers Immunological Heterogeneity Within Rejection Phenotypes
J. Callemeyn¹, B. Lamarthée¹, P. Koshy², T. Debyser³, E. Van Loon¹, A. Franken⁴, T. Van Brussel⁴, I. Arijs⁴, D. Lambrechts⁴, M. Rabant⁵, A. Senev¹, T. Vaulet⁶, C. Tinel¹, M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium, ³Faculty of Medicine, KU Leuven, Leuven, Belgium, ⁴Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, ⁵Necker-Enfants Malades Institute, Institut national de la santé et de la recherche médicale (Inserm), Université de Paris, Paris, France, ⁶ESAT Stadius Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium
*Purpose: Rejection of the kidney allograft is hallmarked by the accumulation of inflammatory cells within the renal architecture, leading to microvascular or tubulointerstitial inflammation. However,…
2022 American Transplant Congress
Parainfluenza Type 3 Infection in Solid Organ Transplant Recipients
G. Motoa¹, M. A. Mendoza¹, M. Raja¹, J. Simkins², S. Anjan², E. Martin², A. Phancao², N. Sinha², L. Abbo¹, G. Guerra², Y. Natori²
¹University of Miami/Jackson Memorial Hospital, Miami, FL, ²Miami Transplant Institute – University of Miami, Miami, FL
*Purpose: Respiratory viral infection, including COVID-19, causes significant morbidity and mortality in solid organ transplant recipients (SOTR), however, the data of parainfluenza virus (PIV) type…
2022 American Transplant Congress
Development and Validation of a Medication Safety Dashboard in Veteran Transplant Recipients: Preliminary Results of a Multicenter Cluster-Randomized Controlled Clinical Trial
D. Taber¹, R. Felkner², K. Rife³, D. Cooney³, S. Laforest³, E. Santa⁴, N. Super⁵, C. Hall⁶, T. Goddard¹, R. Alexander¹
¹MUSC, Charleston, SC, ²Madison VA, Madison, WI, ³Cleveland VA, Cleveland, OH, ⁴Atlanta VA, Atlanta, GA, ⁵Chicago VA, Chicago, IL, ⁶Charleston VA, Charleston, SC
*Purpose: In organ transplant, med errors, adverse drug events, and nonadherence lead to increased healthcare utilization and graft loss. Veterans with transplants are a high-risk…
2022 American Transplant Congress
Accepting Rejection in Liver Transplant Recipients Requiring Renal Replacement Therapy: A Practice Paradigm
S. Farghaly¹, T. Sparkes¹, B. Masters¹, A. Haririan², N. Jakhete³, R. N. Barth⁴, D. Maluf⁵, S. Freedman¹
¹Pharmacy, University of Maryland Medical Center, Baltimore, MD, ²Nephrology, University of Maryland Medical Center, Baltimore, MD, ³Hepatology, University of Maryland Medical Center, Baltimore, MD, ⁴Transplant Surgery, University of Chicago Medical Center, Chicago, IL, ⁵Transplant Surgery, University of Maryland Medical Center, Baltimore, MD
*Purpose: The purpose of this study is to evaluate rejection outcomes in those requiring renal replacement therapy (RRT) after liver transplant.*Methods: This was a single…
2022 American Transplant Congress
Place Based Risk for Early Rejection in Lung Transplant
W. M. Tsuang¹, X. Wang², J. Curtis³
¹Respiratory Institute, Cleveland Clinic, Cleveland, OH, ²Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, ³Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH
*Purpose: Within 5 years after lung transplant (LT), half of recipients have lost 20% or more of lung function. Despite a consistent link between social…
2022 American Transplant Congress
The Relative Association of Clinical Variables and Histologic Lesions with Molecular Rejection in Kidney Transplant Biopsies
M. L. Sikosana¹, J. Reeve², P. F. Halloran², INTERCOMEX Investigators³
¹University of Alberta, Edmonton, AB, Canada, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ³INTERCOMEX, Edmonton, AB, Canada
*Purpose: Availability of molecular assessment (MMDx) independent of conventional variables (time, clinical, histologic, and HLA antibody) presents an opportunity to re-assess the relative strength of…
2022 American Transplant Congress
Surveillance of Donor-Derived Cell-Free DNA Throughout Treatment of Acute Rejection in Pediatric Renal Transplant Recipients
K. A. Klein¹, E. L. Kincaide¹, M. Fei², A. M. Bell², M. Y. Arar³, D. Ranch³
¹Pharmacotherapy Education and Research Center, UT Health San Antonio, San Antonio, TX, ²CareDx, Inc., Brisbane, CA, ³Long School of Medicine, UT Health San Antonio, San Antonio, TX
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a dynamic plasma biomarker for allograft rejection with limited data in pediatric renal transplant recipients and few reports describing…
2022 American Transplant Congress
The Natural History of De Novo DSA After Kidney Transplantation
C. López del Moral¹, N. Lachmann², S. Hergovits², D. Stauch², A. Akifova³, M. Naik³, B. Osmanodja³, D. Schmidt³, K. Budde³
¹Nephrology department-IDIVAL, Hospital Universitario Marqués de Valdecilla, Santander, Spain, ²Institute for Transfusion Medicine, HLA-Laboratory, Charité - Universitätsmedizin, Berlin, Germany, ³Department of Nephrology and Medical Intensive Care, Charité - Universitätsmedizin, Berlin, Germany
*Purpose: De novo donor-specific antibodies(dnDSA) are key in the diagnosis of antibody-mediated rejection(ABMR) and are related to graft loss(GL). Luminex® provides semi-quantitative information with the…
2022 American Transplant Congress
Data-Driven Clustering Distinguishes Infection from Rejection During Hospital Admissions Following Pediatric Lung Transplantation
C. D. Britto¹, D. Boyer², G. Visner³, G. Priebe⁴, L. Midyat³
¹Department of Pediatrics, Boston Children's Hospital, Boston, MA, ²Division of Pulmonary Medicine, Nationwide Children's Hospital, Ohio, MA, ³Division of Pulmonary Medicine, Boston Children's Hospital, Boston, MA, ⁴Department of Anesthesiology, Critical Care and Pain Medicine, Division of Infectious Disease, Boston Children's Hospital, Boston, MA
*Purpose: When lung transplantation patients are admitted with respiratory symptoms, distinguishing between episodes of infection and rejection is central to determining immunosuppressive management.*Methods: Data comprising…