Articles tagged "Rejection"

2022 American Transplant Congress
Utility of Donor Derived Cell-Free DNA in Liver Transplantation
A. Zarrinpar, D. Lewis, C. Warren, S. Duarte
Surgery, University of Florida, Gainesville, FL
*Purpose: As a non-invasive measure of allograft injury, quantifying the fraction of donor-derived cell-free DNA (dd-cfDNA) has proven to be useful technique in kidney transplantation.…
2022 American Transplant Congress
Trends in Donor Derived Cell Free DNA Before and After Cellular and Antibody Mediated Rejection
K. Guo¹, J. Friedewald¹, C. Rebello¹, B. Kinsella¹, S. Park², L. Zhao¹
¹Northwestern University, Chicago, IL, ²Transplant nephrology, Northwestern University, Chicago, IL
*Purpose: The TRAC dd-cfDNA test was developed to detect acute kidney transplant rejection but can also detect subclinical rejection with improved performance in antibody-mediated rejection…
2022 American Transplant Congress
Donor-Derived Cell-Free DNA Testing in Kidney Transplantation: Do One-Month Values Have Any Prognostic Significance?
B. K. Sharda¹, M. Garner¹, A. Farney¹, G. Orlando², J. Rogers², C. Jay³, A. Daniel¹, A. Guiterrez¹, N. Sakhovskaya¹, R. Stratta¹
¹ATRIUM HEALTH Wake Forest Baptist Medical Center, Winston Salem, NC, ²Wake Forest Baptist Medical Center, Winston Salem, NC, ³Wake Forest Baptist Health, Winston-Salem, NC
*Purpose: Plasma-based donor-derived cell-free DNA (dd-cfDNA) assays have been proposed as an alternative to percutaneous renal allograft biopsy which is the current gold standard for…
2022 American Transplant Congress
Utility of Four-Point Mycophenolate Mofetil Testing in a Pediatric Kidney Transplant Population
S. Sadiq, P. Brakeman, J. Brennan, E. Black
Pediatric Nephrology, UCSF, San Francisco, CA
*Purpose: While there is randomized, multicenter data in adults that area under the time concentration curve (AUC) measurements for Mycophenolate Mofetil (MMF) can direct dosing…
2022 American Transplant Congress
Induction Immunosuppression in ABO-Incompatible Liver Transplant Recipients
S. Shaikh¹, I. Hasan¹, N. Kaur²
¹Keck Medicine of USC, Los Angeles, CA, ²Keck School of Medicine, Los Angeles, CA
*Purpose: ABO-incompatible (ABO-i) liver transplantation (LT) has been associated with an increased risk of AMR, as well as poor patient and graft survival. With advances…
2022 American Transplant Congress
Significance of C4d Expression in Peritubular Capillary Concurrent with Microvascular Inflammation in For-Cause Biopsies of ABO-Incompatible Renal Allografts
H. Cho¹, C. Baek², H. Kim³
¹Department of Pathology, Asan Medical Center, Seoul, Korea, Republic of, ²Department of Internal Medicine, Asan Medical Center, Seoul, Korea, Republic of, ³Asan Medical Center, Seoul, Korea, Republic of
*Purpose: ABO incompatible (ABOi) kidney transplantation (KT) has been increasing due to severe organ shortages. Pathologic diagnosis of antibody-mediated rejection (ABMR) in ABOi patients is…
2022 American Transplant Congress
Valganciclovir for the Prevention of CMV After Treatment of Rejection with Anti-Lymphocyte Depleting Antibodies in Kidney Transplant Recipients
M. Mahoney, J. Nelson, E. Kincaide, R. Hall, H. Sweiss
University Health, San Antonio, TX
*Purpose: To evaluate efficacy and safety of valganciclovir for prevention of cytomegalovirus (CMV) after treatment of rejection with anti-lymphocyte depleting antibodies (ALA).*Methods: This single-center retrospective…
2022 American Transplant Congress
The Trajectory of Donor-Derived Cell-Free DNA (dd-cfDNA) Complements the Baseline Measurements in Heart Transplant Surveillance for Rejection
P. Shah¹, R. Cheng², H. Eisen³, B. D. Lowes⁴, L. Lourenco Jenkins⁵, Y. Fu⁵, K. Qu⁵, J. Teuteberg⁶, E. DePasquale⁷
¹Inova Heart and Vascular Institute, Falls Church, VA, ²University of Washington Heart Institute, Seattle, WA, ³Pennsylvania State University, Hershey, PA, ⁴University of Nebraska Medical Center, Omaha, NE, ⁵CareDx, Brisbane, CA, ⁶Stanford University, Stanford, CA, ⁷University of Southern California, Los Angeles, CA
*Purpose: Changes in dd-cfDNA levels over time may identify patients with evolving alloimmune injury, providing complementary information to the donor fraction. We explored the dd-cfDNA…
2022 American Transplant Congress
Deep Phenotyping Methods Highlight Recipient-Derived CD16+ NK and CD16+ Monocyte Infiltration During Kidney Transplant Rejection
B. Lamarthée¹, J. Callemeyn¹, P. Koshy², T. Debyser³, E. Van Loon¹, A. Franken⁴, T. Van Brussel⁴, I. Arijs⁴, D. Lambrechts⁴, A. Senev¹, T. Vaulet⁵, C. Tinel¹, M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Department of Morphology and Molecular Pathology, University Hospitals Leuven, Leuven, Belgium, ³Faculty of Medicine, KU Leuven, Leuven, Belgium, ⁴Laboratory for Translational Genetics, Department of Human Genetics, KU Leuven, Leuven, Belgium, ⁵ESAT Stadius Center for Dynamical Systems, Signal Processing and Data Analytics, KU Leuven, Leuven, Belgium
*Purpose: How the immune system participates to kidney transplant rejection has not been fully elucidated. Single-cell (sc) genomics techniques are revolutionizing our ability to characterize…
2022 American Transplant Congress
Impact of ATG Dose Reduction on Kidney Transplant Outcomes During the Covid-19 Pandemic
P. A. Than¹, F. De Leon¹, K. Jen², N. Goussous¹, R. V. Perez¹, A. X. Wang³
¹Transplant Surgery, UC Davis, Sacramento, CA, ²Pathology, UC Davis, Sacramento, CA, ³Transplant Nephrology, UC Davis, Sacramento, CA
*Purpose: During the COVID-19 pandemic, many transplant centers modified induction immunosuppression regimens. Beginning December 2020, our center reduced anti-thymocyte globulin (ATG) protocol dosing by up…