2015 American Transplant Congress
DSA Detected by ELISA-PRA Is Associated With High Risk for Development of AMR in Stable Kidney Transplant Recipients
Background: Donor specific anti-HLA antibodies (DSA) are a major cause of antibody mediated rejection (AMR) and allograft loss, determining how to monitor patients for DSA…2015 American Transplant Congress
The Impact of Baseline and Follow-Up Social Adaptability Index Scores on Outcomes in Kidney Transplantation
Globally, socioeconomic status (SES) is a significant determinant of health outcomes, with the social adaptability index (SAI) representing a quantifiable and validated surrogate of SES.…2015 American Transplant Congress
Renal Allografts Demonstrate Improved Pathology After Belatacept Therapy
1University of Maryland School of Medicine, Baltimore; 2Johns Hopkins University, Baltimore.
Belatacept provides immunosuppression via costimulation blockade and has been associated with improved renal function compared to calcineurin inhibitor based therapies. We developed the Maryland Aggregate…2015 American Transplant Congress
Urinary Cell-Free DNA Is a Sensitive Marker of Early Renal Transplant Injury
Surgery, UC San Francisco, San Francisco, CA.
Introduction:Circulating donor-derived cell-free DNA (dd-cfDNA) has been reported as a surrogate of transplant injury in the blood but requires expensive donor and recipient DNA sequencing.Method:…2015 American Transplant Congress
Which Place of Pancreas Graft Biopsy in the Management of Pancreas Transplant Recipients?
Hospices civils de Lyon, Lyon, France.
Introduction.Rejection or autoimmune recurrence is often difficult to diagnose in the field of pancreas transplantation. The place of pancreas graft biopsy in the management of…2015 American Transplant Congress
Activation of Th17 and Chronic Renal Allograft Rejection in Nonhuman Primates
Transplant Center, Massachusetts General Hospital, Boston, MA.
Background: We have previously reported successful induction of renal allograft tolerance in nonhuman primates (NHP) via a mixed chimerism approach. Although donor specific Th1 and…2015 American Transplant Congress
Prognostic Relevance of Rejection Episodes Detected Within the First 3 Weeks After Kidney Transplantation
Background:The relevance of cellular rejection events detected in the early phase after kidney transplantation for graft survival and function remains to be elucidated. Especially the…2015 American Transplant Congress
A Cross-Organ Tissue Gene Expression Immune Signature Predates Chronicity
Transplantation Surgery, UC San Francisco, San Francisco, CA.
Purpose Meta-analysis of 796 microarrays led to the discovery of 11 over-expressed genes (BASP1, CD6, CXCL9, CXCL10, INPP5D, ISG20, LCK, NKG7, PSMB9, RUNX3, and TAP1)…2015 American Transplant Congress
The Effect of Influenza Vaccination on Hospital Admission in Solid Organ Transplant Recipients
Emory University Hospital, Atlanta, GA.
Purpose: The current study has two objectives. First, compare clinical outcomes between solid organ transplant (SOT) recipients who receive influenza vaccination and those who do…2015 American Transplant Congress
Stimulating Protease Inhibitor 9 Expression By Human Regulatory T Cells Improve Homeostasis
Renal/ Transplantation Research Center, Brigham and Women's Hospital, Boston, MA.
In this study, we show for the first time the key role of a protease inhibitor PI9 in human regulatory T cells (Tregs) homeostasis. Recent…
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