Articles tagged "Rejection"

2022 American Transplant Congress
Gm2a: A Novel Regulatory Pathway Controlling CD8⁺ T Cell Alloimmunity
K. M. Baecher¹, J. Bazzano¹, K. Tong¹, M. Fribourg², P. Cravedi², P. S. Heeger², M. L. Ford¹
¹Department of Surgery, Emory University, Atlanta, GA, ²Mount Sinai School of Medicine, New York, NY
*Purpose: Transplant recipients experience lifelong immunosuppression, yet studies have shown that a subset of patients may be able to retain stable graft function even with…
2022 American Transplant Congress
Standard Induction with Basiliximab versus no Induction in Low Immunological Risk Kidney Transplant Recipients: Study Protocol for a Randomized Controlled Trial
A. Ajlan¹, H. Aleid¹, T. Ali¹, H. Joharji¹, Z. Alabdulkarim¹, T. Aburiash¹, K. Almeshari¹, A. Nazmi¹, Y. Shah¹, E. Devol¹, D. Alkortas¹, D. Broering¹, I. Alahmadi¹, A. Ullah¹, A. Alotaibi¹, A. Aljedai²
¹KFSHRC, RIYADH, Saudi Arabia, ²MOH, RIYADH, Saudi Arabia
*Purpose: To compare different induction therapeutic strategies with 2 doses of basiliximab vs. no induction in low immunologic risk kidney transplant recipients as per KFSHRC…
2022 American Transplant Congress
Urinary Exosomal MicroRNA Biomarkers for Antibody-Mediated Rejection After Kidney Transplantation
S. Shin, M. Kim, S. Lim, H. Kwon, J. Jung, Y. Ko, H. Kwon, Y. Kim
Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, Republic of
*Purpose: We aimed to identify urine-derived exosomal miRNAs as diagnostic biomarkers for antibody-mediated rejection (ABMR) after kidney transplantation.*Methods: Exosomal miRNAs using differential ultracentrifugation were isolated…
2022 American Transplant Congress
Use of Three-Dimensional Volumetric Analysis to Monitor Acute Rejection in a Face Transplant Recipient
D. Boczar¹, H. Brydges¹, O. C. Onuh¹, B. F. Chaya¹, J. Trilles¹, R. Rodriguez Colon¹, D. J. Ceradini¹, B. E. Gelb², E. D. Rodriguez¹
¹Hansjörg Wyss Department of Plastic Surgery, NYU Langone Health, New York, NY, ²Transplant Institute, NYU Langone Health, New York, NY
*Purpose: The purpose of this study is to determine the feasibility of using 3D facial stereography to monitor volume changes in a facial allograft, and…
2022 American Transplant Congress
B and Plasma Cell Populations Drive Chronic Rejection After Lung Transplantation
M. Bueno¹, N. F. Smirnova², K. Riemondy³, P. Suresh¹, M. Brown¹, X. Wang¹, S. Collins⁴, J. Sembrat¹, M. Koenigshoff¹, M. Snyder¹, J. McDyer¹, O. Eickelberg¹
¹Pulmonary and Critical Care Medicine, University of Pittsburgh, Pittsburgh, PA, ²I2MC, INSERM UMR1297, Toulouse, France, ³Biochemistry and Molecular Genetics, University of Colorado School of Medicine, Aurora, CO, ⁴Pulmonary Sciences and Critical Care Medicine, University of Colorado School of Medicine, Aurora, CO
*Purpose: Chronic lung allograft dysfunction (CLAD) remains the major determinant of morbidity and mortality post-lung transplantation (LTx). Bronchiolitis obliterans syndrome (BOS) is the most prevalent…
2022 American Transplant Congress
Delta Changes in Donor-Derived Cell-Free DNA (dd-cfDNA) Complement the Donor Fraction in Kidney Transplant Surveillance
A. Wiseman¹, M. Jagadeesan², G. Gupta³, V. Rao⁴, M. Narayanan⁵, N. Agrawal⁶, G. Shekhtman⁶, Y. Fu⁶, K. Pinney⁶, S. Anand⁷
¹Centura Health, Denver, CO, ²George Washington University, Washington, DC, ³Virginia Commonwealth University, Richmond, VA, ⁴Medical University of South Carolina, Charleston, SC, ⁵Baylor Scott and White, Austin, TX, ⁶CareDx, Brisbane, CA, ⁷Intermountain Healthcare, Murray, UT
*Purpose: Delta changes in dd-cfDNA levels over time may identify patients with evolving alloimmune injury, providing complementary information to the donor fraction. We explored the…
2022 American Transplant Congress
Use of De Novo mTOR Inhibitors in Highly Sensitized Kidney Transplant Recipients
J. Bastos¹, T. Freesz², C. Bisi³, C. Marinho², A. Pires², V. Colares³, R. Neto², G. Ferreira²
¹Tranplant Unit, Santa Casa De Misericordia De Juiz de Fora, Juiz de Fora, Brazil, ²Transplant Unit, Santa Casa De Misericórdia De Juiz de Fora, Juiz de Fora, Brazil, ³Tranplant Unit, Santa Casa De Misericórdia De Juiz de Fora, Juiz de Fora, Brazil
*Purpose: mTOR inhibitors (mTORi) allow calcineurin-inhibitor reduction without loss of efficacy and may improve allograft-transplant outcomes. However, the safety of this protocol in high-immunological risk…
2022 American Transplant Congress
Re-Examining the Optimal Threshold for Donor Derived Cell Free DNA in Renal Allograft Rejection
H. Murad¹, M. Merzkani¹, M. Ji¹, S. Chang¹, A. Malone¹, R. Delos Santos¹, T. Alhamad²
¹Washington University in St. Louis, St Louis, MO, ²Washington University in St. Louis, Saint Louis, MO
*Purpose: Due to the invasive nature and potential complications of allograft biopsies, there is an important role for surrogate biomarkers to help identify rejection early,…
2022 American Transplant Congress
Time-Dependent Blood Eosinophilia Count Increases the Risk of Kidney Allograft Rejection
L. Colas¹, L. Bui², C. Kerleau³, M. Lemdani⁴, K. Autain-Renaudin⁵, A. Magnan⁶, M. Giral³, S. Brouard¹
¹CRT2I, Université de Nantes, Nantes, France, ²Service de Néphrologie, Centre Hospitalier de Mouscron, Mouscron, Belgium, ³Service de Néphrologie et Immunologie Clinique, CHU de Nantes, Nantes, France, ⁴Département de Biomathématiques, Université de Lilles, Lilles, France, ⁵Service d'Anatomie et Cytologie Pathologique, CHU de Nantes, Nantes, France, ⁶INRAe UMR 0892, Université de Versailles Saint-Quentin Paris-Saclay, Paris, France
*Purpose: There is growing evidence that type 2 immune effectors (immunoglobulin E, eosinophils, mast cells/basophils) play a role in autoimmune disorders and solid organ transplantation.…
2022 American Transplant Congress
Single Kidney Transplantation Using Pediatric Donor Kidneys: Satisfactory Outcomes but Specific Attentions Needed
M. Huang, W. Wu, X. Su, J. Li, C. Wu, H. Zhang, Q. Fu, J. Li, S. Wu, Y. Chen, Q. Zhang, L. Liu, C. Wang
The First Affiliated Hospital Of Sun Yat-sen University, Guangzhou, China
*Purpose: Utilization of pediatric donor in single kidney transplantation (SKT) are popular and can greatly expand the scarce donor pool, whereas potential risk factors remain…