Articles tagged "Rejection"

2015 American Transplant Congress
Transplant Glomerulopathy in a Novel Model of Chronic Antibody Mediated Rejection Is Associated With DSA and Glomerular IgM
S. Panzer,¹ S. Reese,¹ N. Wilson Schlei,¹ W. Zhong,² A. Djamali.¹
¹Medicine, University of Wisconsin Madison, Madison, WI; ²Pathology, University of Wisconsin Madison, Madison, WI.
PurposeChronic active antibody mediated rejection (cAMR) and transplant glomerulopathy (TG) are major determinants of long-term allograft survival. However, the contribution of DSA and glomerular immunoglobulins…
2015 American Transplant Congress
Does Switching Predict Conversion: IgM De Novo Donor Specific HLA Antibodies Class Switch to IgG in Subclinical Antibody Mediated Rejection in Heart Transplant Recipients
M. Askar,¹ R. Rodriguez,¹ L. Klingman,¹ D. Thomas,¹ A. Zhang,¹ H. Morf,² N. Hamon,¹ N. Moazami,¹ E. Hsich,¹ D. Taylor,¹ R. Starling,¹ C. Tan.¹
¹Cleveland Clinic, Cleveland; ²School of Medicine, Leipzig University, Leipzig, Germany.
Background: Concomitant C4d and C3d detection in heart biopsies correlates with circulating DSA and graft dysfunction. Detection of C4d only in surveillance biopsies is not…
2015 American Transplant Congress
An Orchestrated Sequence of Innate and Adaptive Immune Responses Is Associated With Rejection After Pediatric Liver Transplantation
C. Falk,¹ I. Goldschmidt,² F. Mutschler,² C. Neudörfl,¹ J. Keil,¹ K. Daemen,¹ F. Lehner,³ R. Mikolajzcyk,⁴ A. Karch,⁴ U. Baumann.²
¹Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; ²Division of Pediatric Gastroenterology and Hepatology, Hannover Medical School, Hannover, Germany; ³Department of Visceral General and Transplant Surgery, Hannover Medical School, Hannover, Germany; ⁴Department of Epidemiology, Helmholtz Center for Infection Research, HZI, Braunschweig, Braunschweig, Germany.
The concept of a coordinated immune response initiated by innate and sustained by adaptive immune cells and their soluble mediators is well established for infection…
2015 American Transplant Congress
The Clinical Outcome of Plasma Cell-Rich Rejection of Kidney Allograft
J. Hasegawa,¹ K. Honda,² S. Wakai,¹ H. Shirakawa,³ M. Okumi,³ K. Omoto,³ H. Ishida,³ K. Tanabe.³
¹Nephrology, Ohkubo Hospital, Tokyo, Japan; ²Pathology, Tokyo Women's Medical University, Tokyo, Japan; ³Urology, Tokyo Women's Medical University, Tokyo, Japan.
Background: Plasma cell-rich rejection (PCRR) is a rare type of allograft rejection characterized by the presence of mature plasma cells. This type of rejection has…
2015 American Transplant Congress
Renal Outcomes of Cross Match Positive Simultaneous Liver Kidney (SLK) Transplant Recipients Compared to Cross Match Positive Kidney Allograft Recipients
S. Vaishnav,¹ T. Taber,¹ W. Goggins,² S. Nagaraju,² J. Fridell,² A. Sharfuddin,¹ M. Yaqub,¹ D. Mishler,¹ M. Mujtaba.¹
¹IUSM, IU Health, Indianapolis, IN; ²Surgery, Transplant, Indiana University School of Medicine, Indianapolis, IN.
The protective role of liver in cross-match(XM) positive SLK recipients and its impact on the incidence of renal antibody mediated rejection (AMR) is unclear.A retrospective…
2015 American Transplant Congress
Pretransplant Antibodies Against Angiotensin II Type 1 Receptor in Renal Transplantation: Preliminary Data from the KNOW-KT Study
K. Huh,¹ J. Lee,¹ Y. Park,² Y. Kim,¹ C. Ahn.³
¹Department of Transplantation Surgery, Yonsei University Health System, Seoul, Republic of Korea; ²Department of Laboratory Medicine, Yonsei University Health System, Seoul, Republic of Korea; ³Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea.
BackgroundThe antibodies (Abs) against angiotensin II type 1 receptor (AT1R) have been suggested as a risk factor for graft failure and acute rejection. However, incidence…
2015 American Transplant Congress
Thymoglobulin Versus IL2RA: Three Year Results of a Randomized Controlled Trial
N. Pilch, H. Meadows, D. Taber, J. Fleming, C. Mardis, S. Nadig, J. McGillicuddy, T. Srinivas, C. Bratton, P. Baliga, K. Chavin.
Transplant, MUSC, Charleston, SC.
This is a three year follow-up of a prospective, randomized controlled trial (RCT) to determine the safety and efficacy of induction with rabbit antithymocyte globulin…
2015 American Transplant Congress
Constitutively Upregulated Expression of Complement and Matrix Transcripts in Kidney Transplant Recipients Who Develop Acute Rejection
K. Keslar,¹ J. Reid-Adam,⁴ E. Kwon,⁴ D. Hricik,⁵ E. Poggio,^2,3 P. Heeger,⁴ R. Fairchild.^1,3
¹Immunology, Cleveland Clinic; ²Nephrology, Cleveland Clinic; ³Glickman Urological Institute and Transplant Center, Cleveland Clinic, Cleveland, OH; ⁴Icahn School of Medicine, Mount Sinai, New York, NY; ⁵Nephrology, UH Case Medical Center, Cleveland, OH.
Identification of kidney transplants at elevated risk of acute rejection (AR) and/or chronic injury prior to loss of kidney function (GFR) could guide therapies to…
2015 American Transplant Congress
Clinicopathological Scenarios (CPS) Defined by Viremia, Creatinine and Histology in Polyomavirus Nephropathy Differ in 1st and 2nd (Follow-Up) Biopsy
C. Drachenberg, M. Chaudhry, F. Yang, R. Ugarte, A. Haririan, M. Mavanur, C. Cangro, B. Thomas, N. Costa, E. Ramos, M. Weir, J. Papadimitriou.
Pathology and Medicine, University of Maryland School of Medicine, Baltimore, MD.
Studies of sequential kidney biopsies (KB) after the diagnosis of polyomavirus allograft nephropathy (PVN) are scarce and clinicopathological evolution of PVN poorly understood. In practice…
2015 American Transplant Congress
Kidney Transplantation (KTx) With Positive Crossmatch (XM) but No Donor Specific Antibody (DSA)
J. Verbesey, O. Timofeeva, L. Dong, B. Javaid, G. Monica, A. Gilbert, J. Moore, P. Weems, S. Ghasemian, S. Rosen-Bronson, M. Cooper.
MedStar Georgetown Transplant Institute, Washington, DC.
Purpose: Prior to KTx, a XM is performed between the intended recipient and donor. This XM can be positive despite no DSA. It can be…