2016 American Transplant Congress
The Effect of Maternal Graft in Early Acute Cellular Rejection After Pediatric Living Donor Liver Transplantation.
Objectives: It has been reported that the living donor liver transplantation (LDLT) in which the patients received a maternal graft could be more successful compared…2016 American Transplant Congress
Development and Validation of a Molecular Microscope Diagnostic System (MMDx) for Heart Transplant Biopsies.
The diagnosis of heart transplant rejection by histology in endomyocardial biopsies (EMB) is challenging. A molecular system (MMDx) has been developed to assess both T…2016 American Transplant Congress
Role of NRP1 in CD4+ T Cell Allo-Activation.
Department of Surgery, Boston Children's Hospital, Boston, MA.
Introduction: Neuropilin-1 (NRP1) is a transmembrane glycoprotein that functions as a co-receptor for class III/IV semaphorins, VEGF, and several other growth factors. NRP1 has been…2016 American Transplant Congress
Avoidance of CNI and Steroids Using Belatacept – A Preliminary Report of CTOT-16.
1UAB, Birmingham; 2UCSF, San Francisco; 3Emory, Atlanta; 4Rho, Chapel Hill; 5NIAID, Bethesda.
CTOT-16 tested the hypothesis that belatacept used as maintenance immunosuppression (IS) in kidney transplantation would allow the long-term avoidance of CNI and corticosteroids. Methods: Primary…2015 American Transplant Congress
Antibody-Mediated Rejection of Renal Allografts by CCR5-/- Mice Does Not Require CD8 T Cells
Antibody-mediated acute and chronic graft injury remains a major cause of renal allograft loss. Mechanisms underlying these injuries remain unclear due in part to the…2015 American Transplant Congress
Serum Proteins Are Significantly Upregulated in Patients With Clinical Antibody-Mediated Rejection
Background: Antibody-mediated rejection (ABMR) is a major pathway associated with late graft loss. Although serum de novo donor-specific HLA antibodies are frequently observed in ABMR,…2015 American Transplant Congress
Focal Segmental Glomerulosclerosis Recurrence in Renal Transplant Recipients Treated With Belatacept
Introduction: Focal segmental glomerulosclerosis (FSGS) is a cause of end-stage renal failure that frequently recurs following renal transplant, often leading to early allograft loss. A…2015 American Transplant Congress
Characteristics and Consequences of Renal Allograft Rejections Due to Nonadherence
Houston Methodist Hospital, Houston.
Non-adherence (NA) with immunosuppressive medications is associated with increased healthcare costs, rejection risk, and graft loss. NA is difficult to measure, however, and is often…2015 American Transplant Congress
Histologic Findings in Pre-transplant AT1Rab + ve Patients Point to an Increase in Sub-Intimal Fibrosis During Acute Rejection and in 12 mo. Protocol Renal Graft Biopsies
Previous reports have described an increase in arteritis during acute rejection (AR) in angiotensin II type 1 receptor antibody (AT1Rab) positive (ve+) kidney transplant recipients…2015 American Transplant Congress
Preformed Anti-HLA DP Donor Specific Antibodies Are Clinically Significant in Renal Transplantation
Renal and Transplant Medicine, Imperial Healthcare NHS Trust, London, United Kingdom.
Background: Whilst preformed [PF] anti-HLA A, B, DR and DQ donor specific antibodies [DSAbs] are associated with poorer allograft outcomes secondary to antibody mediated injury,…
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