ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2016 American Transplant Congress

    Influence of Donor and Recipient CYP3A4, CYP3A5 and ABCB1 Genotypes on Outcomes in Liver Transplants.

    M. Debette-Gratien,1 J. Woillard,2 N. Picard,2 M. Sebbagh,4 D. Sautereau,5 V. Loustaud-Ratti,1 D. Samuel,3 P. Marquet.2

    1Hepatology, INSERM UMR 850, Univ Limoges, CHU Limoges, Limoges, France; 2Pharmacology and Toxicology, INSERM UMR 850, Univ Limoges, CHU Limoges, Limoges, France; 3Hepatology, INSERM U785, Centre hépatobiliaire, Villejuif, France; 4Hepatology, Centre Hépatobiliaire, Villejuif, France; 5Hepatology, CHU Limoges, Limoges, France.

    Liver transplantation is a life-saving technique for patients with end-stage liver disease. Pharmacogenetics is promising to explain a part of variability of calcineurin inhibitors efficacy…
  • 2016 American Transplant Congress

    Systematic Pathological Component Scores for Skin-Containing Vascularized Composite Allografts.

    I. Rosales,1 M. DeFazio,2 R. Foreman,1 D. Sachs,2 C. Cetrulo,2 D. Leonard,2,3 R. Colvin.1

    1Pathology, Massachusetts General Hospital, Boston; 2Transplantation Biology Research Center, Plastic and Reconstructive Surgery, Massachusetts General Hospital, Boston; 3Plastic and Reconstructive Surgery, Countess of Chester Hospital, Chester, United Kingdom.

    Successful application of skin-containing vascularized composite allografts (VCA) depends on accurate assessment of the graft status typically based on skin biopsies. A working classification (Banff…
  • 2016 American Transplant Congress

    Protective Impact of the Kidney in SPK Transplants – Mechanisms for Improved Outcomes Compared with Solitary Transplants.

    E. Finger, T. Dunn, A. Kukla, V. Kirchner, R. Kandaswamy.

    Surgery, University of Minnesota, Minneapolis, MN.

    Purpose: Outcomes for SPK txps are superior to solitary pancreas txps. The basis for this difference is unknown. We sought to identify the biologic mechanism…
  • 2016 American Transplant Congress

    Induction Therapy with Depleting Antibodies in Low Immunological Risk Renal Transplant Patients Treated with a Steroid Free Regimen – Comparison of Alemtuzumab vs. Antithymocyte Globulin.

    N. Bossini,1 S. Sandrini,1 R. Tardanico,2 F. Valerio,1 G. Setti,1 C. Salviani,1 S. Possenti,1 P. Foini,1 E. Marta,1 G. Cancarini.1

    1Division and Chair of Nephrology, A.O "Spedali Civili" and University, Brescia, Italy; 2Division and Chair of II Laboratory of Pathology, A.O "Spedali Civili" and University, Brescia, Italy.

    Induction therapy with depleting antibodies reduces rejection rate and potentially improves efficacy of steroid free regimens after renal transplantation.This prospective, single-centre, cohort study evaluated cumulative…
  • 2015 American Transplant Congress

    Clinical Subclassifiation of ABMR Phenotypes: Recognizing Variation in Presentation

    P. Halloran, M. Lopez, I. Salazar, J. Chang.

    Alberta Transplant Applied Genomics Centre, Edmonton, Canada.

    The diagnosis of ABMR in kidney transplants is based on ptc-, g- and cg-lesions in biopsies and donor-specific antibody (DSA). To recognize the actual phenotypes…
  • 2015 American Transplant Congress

    Prediction of Acute Antibody Mediated Rejection in Antibody Incompatible Renal Transplantation Using Machine Learning for Wide Data

    T. Shaikhina,1 N. Khovanova,1 S. Daga,1,3 N. Krishnan,2 D. Lowe,3 D. Mitchell,1 D. Briggs,2 R. Higgins.3

    1University of Warwick, Coventry, United Kingdom; 2NHS Blood and Transplant, Birmingham, United Kingdom; 3University Hospitals Coventry and Warwickshire, Coventry, United Kingdom.

    The dynamic field of renal transplantation is characterised by limited access to data, the high cost of equipment and underlying complexity of immunological responses to…
  • 2015 American Transplant Congress

    The Effect of Rituximab Therapy on Regulatory B Cell and Prevention of Chronic Antibody Mediated Rejection in Kidney Transplantation Recipients

    M. Ikemiyagi, R. Ishii, S. Miyairi, T. Hirai, K. Omoto, K. Tanabe.

    Urology, Tokyo Women's Medical University, Tokyo, Japan.

    We previously reported that a single administration of low dose rituximab (RIT) before kidney transplant reduced the incidence rate of chronic antibody mediated rejection (CAMR)…
  • 2015 American Transplant Congress

    Kynurenine Assay to Detect Inflammation in Transplant Patient: Clinical Results

    D. Abendroth,1 J. Kaden,2 M. Marzinzig,1 M. Stangl.3

    1Center of Surgery, University of Ulm, Ulm, Germany; 2Renal Transplant Center, Municipal Friedrichshain Hospital, Berlin, Germany; 3General, Visceral and Transplant Surgery, Ludwig-Maximilians-Universität, München, Munich, Germany.

    Introduction: Ideal biomarker should be specific, sensitive, non-invasive, mirror the benefit of therapy and offer prognostic potential. We developed a test using a colorimetric assay…
  • 2015 American Transplant Congress

    Pertubations in the Urinary Exosome in Transplant Rejection

    T. Sigdel,1 Y. Ng,1 S. Lee,2 C. Nicora,3 W.-J. Qian,3 D. Camp II,3 M. Sarwal.1

    1Surgery, UC San Francisco, San Francisco, CA; 2Nephrology, Kyung Hee University, Seoul, Korea; 3Biological Sciences Division, Pacific Northwest National Laboratory, Richland, WA.

    Urine exosomes are small vesicles shed into the urine by exocytosis from all renal epithelial cell types under normal physiologic states and disease states, and…
  • 2015 American Transplant Congress

    Repeat Donor HLA Mismatch Antigens and Kidney Transplant Outcome

    P. Lokhandwala,1 M. Wang,2 Z. Kadry,3 R. Shah,3 A. Jain,3 J. Gaspari,1 N. Ghahramani,4 C. Abendroth,1 H. Shike.1

    1Pathology, Penn State Hershey Medical Center, Hershey, PA; 2Public Health Sciences, Penn State College of Medicine, Hershey; 3Transplant Surgery, PSHMC, Hershey; 4Nephrology, PSHMC, Hershey.

    Background: Historically, poorer outcome has been reported in kidney re-transplant patients with repeat HLA mismatch antigens. Transplant practice has evolved. Risk of repeat mismatch antigen…
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