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Articles tagged "Rejection"

  • 2016 American Transplant Congress

    Acute Rejection by Belatacept (Bela) Dosing Frequency: Results from a Phase II Study of Kidney Transplant Recipients.

    F. Vincenti,1 G. Blancho,2 A. Durrbach,3 G. Grannas,4 J. Grinyó,5 U. Meier-Kriesche,6 M. Polinsky,6 H. Zhao,6 C. Larsen.7

    1UCSF, San Francisco, CA; 2University Hospital of Nantes, Nantes, France; 3University Hôpital of Bicêtre, Le Kremlin-Bicêtre, France; 4Medizinische Hochschule Hannover, Hannover, Germany; 5University Hospital of Bellvitge, Bellvitge, Spain; 6Bristol-Myers Squibb, Lawrenceville, NJ; 7Emory University Transplant Center, Atlanta, GA.

    Background: At 1 year post transplant in IM103-100 (NCT00035555), bela-treated patients had similar acute rejection (AR) rates and significantly improved renal function vs cyclosporine A…
  • 2016 American Transplant Congress

    Kidney Transplant Recipient Adherence Measured by Proportion of Days Covered Is Associated with Late Biopsy Proven Acute Rejection.

    B. Hofmeyer, K. Look, J. Fose, A. Pulvermacher, A. Djamali, D. Hager.

    UW Health, Madison, WI.

    While medication non-adherence is a known risk factor for late “biopsy proven acute rejection (BPAR),” the Pharmacy Quality Alliance definition of “proportion of days covered…
  • 2016 American Transplant Congress

    Fecal Microbiota Transplant Results in Durable Changes to Host Microbiota That Correlate with Allograft Outcome.

    C. Brinkman, L. Hittle, W. Fricke, E. Mongodin, J. Bromberg.

    CVID and IGS, University of Maryland School of Medicine, Baltimore, MD.

    Hypothesis: We previously presented highly significant differences in the bacterial community structures of human renal allograft recipients over time. Likewise, murine normal, colitic, and pregnant…
  • 2016 American Transplant Congress

    Profiling Immunologic Risk for Acute Rejection in Liver Transplantation: Recipient Age Is a Robust Risk Factor.

    M. Kueht, R. Cotton, C. O'Mahony, J. Goss, A. Rana.

    Surgery, Division of Abdominal Transplantation and Hepatobiliary Surgery, Balyor College of Medicine, Houston, TX.

    Profiling the immunologic risk for acute rejection in liver transplantation (OLT) may allow for selection immunosuppression (IS) target ranges appropriate to risk levels, all with…
  • 2015 American Transplant Congress

    The Effect of Influenza Vaccination on Hospital Admission in Solid Organ Transplant Recipients

    J. Rago, M. Hurtik, S. Todd, A. Mehta, G. Lyon III.

    Emory University Hospital, Atlanta, GA.

    Purpose: The current study has two objectives. First, compare clinical outcomes between solid organ transplant (SOT) recipients who receive influenza vaccination and those who do…
  • 2015 American Transplant Congress

    Stimulating Protease Inhibitor 9 Expression By Human Regulatory T Cells Improve Homeostasis

    P. Lukyanchykov, Z. Solhjou, A. Radwan, L. Riella, A. Chandraker, R. Abdi, J. Azzi.

    Renal/ Transplantation Research Center, Brigham and Women's Hospital, Boston, MA.

    In this study, we show for the first time the key role of a protease inhibitor PI9 in human regulatory T cells (Tregs) homeostasis. Recent…
  • 2015 American Transplant Congress

    Significant Association Between Foxp3 Gene Polymorphism and Outcomes in HBV-Related Liver Transplant Patients

    Y. Tanaka, V. Sapana, H. Ohdan.

    Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.

    Background: Previous studies have demonstrated that CD4+Foxp3+ regulatory T (Treg) cells regulate HBV-related disease progression. The present study investigated the association between Treg cells and…
  • 2015 American Transplant Congress

    Vascularised Composite Allografts and Intestinal Transplantation: Does the Skin Component Provide a Pre-Rejection Marker for the Visceral Organ?

    G. Vrakas, H. Giele, R. Arantes, S. Reddy, P. Friend, A. Vaidya.

    Oxford Transplant Centre, Oxford University Hospitals, Oxford, United Kingdom.

    Introduction: Can the skin component of a synchronously transplanted vascularised composite allograft (VCA) be used as a pre-rejection marker for the intestinal transplant (IT)?Methods: Recipients…
  • 2015 American Transplant Congress

    Increased Precentage of Circulating CD16+ Monocytes Before Transplantation Are Associated With the Occurence of Acute Rejection

    T. van den Bosch,1 L. Hilbrands,2 M. Kraaij,1 E. Vereyken,1 P. Leenen,3 D. Hesselink,1 C. Baan,1 A. Rowshani.1

    1Department of Internal Medicine, section Nephrology and Kidney Transplantation, Erasmus Medical Center, Rotterdam, Netherlands; 2Department of Nephrology, Radboud University Nijmegen Medical Center, Nijmegen, Netherlands; 3Department of Immunology, Erasmus Medical Center, Rotterdam, Netherlands.

    Introduction: Monocytes compose a neglected immune cell type in transplantation despite their contribution to antibody mediated rejection. We aimed to define the phenotypic and functional…
  • 2015 American Transplant Congress

    Serum Creatinine Is Most Predictive of Graft Loss in Late Antibody Mediated Rejection

    G. Agarwal, D. Diskin, R. Reed, J. Locke, V. Kumar.

    Comprehensive Transplant Institute, University of Alabama at Birmingham, Birmingham, AL.

    Development of acute antibody mediated rejection (AMR) is associated with graft loss and can occur both early (< 3 months) and late (> 3 months)…
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