2022 American Transplant Congress
Strada Deficiency Results in Inhibition of Tumor Suppressor Gene Liver Kinase B1 Resulting in Epithelial Mesenchymal Transition Leading to Chronic Murine Lung Allograft Rejection
St. Joseph’s Hospital and Medical Center, Phoenix, AZ
*Purpose: Recently we demonstrated that tumor suppressor gene Liver Kinase B1 (LKB1) is down regulated in lung biopsies and in the circulating exosomes of lung…2022 American Transplant Congress
Ficoll-Based Isolation Alters the Immunogenicity of Islets That Leads to Enhanced Rejection in Allogeneic Hosts
*Purpose: The purification of pancreatic islets has long relied on the time-consuming density gradient separation method. We herein report a filtration method as an efficient,…2022 American Transplant Congress
Comparative Analysis of kSORT Assay for Predicting Acute Renal Allograft Rejection Under Belatacept-Based Immunosuppression
*Purpose: The kSORT (Kidney Solid Organ Response Test) assay uses transcriptomic profiling of peripheral blood to predict the presence of acute rejection (AR) in renal…2022 American Transplant Congress
Technology-Driven Performance Improvement of a Biomarker Panel in Kidney Transplant: OmniGraf
*Purpose: Analyze the impact of the transition from TruGraf microarray to TruGraf PCR on the complementary performance characteristics of TruGraf plus TRAC (OmniGraf).*Methods: Development of…2022 American Transplant Congress
Treatment Modality and Outcomes of Antibody-Mediated Rejection in Pediatric Kidney Transplant Recipients: The PARAMOUr Study
*Purpose: Antibody-mediated rejection (AMR) is the leading cause of graft failure in kidney transplantation, but evidence for effective treatments is limited.*Methods: PARAMOUr is a retrospective…2022 American Transplant Congress
High Pretransplant FGF-23 Level is Associated with Poor Graft Survival and Persistent Vitamin D Insufficiency in Kidney Transplant Patients
*Purpose: Vitamin D [25(OH)D] insufficiency and FGF-23 elevation in chronic kidney disease (CKD) is usually ameliorated after kidney transplantation (KT). However, post-transplant vitamin D insufficiency…2022 American Transplant Congress
Autologous Mesenchymal Stem Cells for Treatment of Chronic Antibody-Mediated Kidney Graft Rejection: Report of the First Phase I/II Clinical Case Series
*Purpose: The aim of this study is to evaluate the safety and efficacy of autologous mesenchymal stem cellc (MSCs) in combination with standard of care…2022 American Transplant Congress
HLA-DRB1 and DQB1 Amino Acid Mismatches as Determinants of Kidney Allograft Failure
*Purpose: It was previously reported that HLA-DRB1 amino acid (AA) mismatches (MMs) at peptide-binding pockets of this molecule account for significant incremental risk of kidney…2022 American Transplant Congress
A Real-World Analysis with the Molecular Microscope Diagnostic System in Dual-Organ Transplant Recipients
*Purpose: The Molecular Microscope Diagnostic System (MMDx) analyzes ribonucleic acid transcripts to provide sophisticated differentiation amongst T-cell mediated rejection (TCMR), antibody mediated rejection (AMR), injury…2022 American Transplant Congress
Of the Individual Components of a Modified Freid Frailty Score, Pre-Transplant Walk Time and Grip Strength Are the Strongest Predictors of Post Kidney Transplant Outcomes
University of Wisconsin, Madison, WI
*Purpose: Frailty assessment has become common during evaluation for kidney transplantation; however, a variety of different tools are used for frailty assessment. The Freid frailty…
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