Articles tagged "Rejection"

2016 American Transplant Congress
Post-Trial Experience with Belatacept: A Large Single Center Experience.
A. Adams, C. Garrett, J. Goldstein, R. Zhang, A. Guasch, S. Pastan, R. Patzer, A. Kirk, T. Pearson, C. Larsen.
Emory Transplant Center, Atlanta, GA.
Evaluation of belatacept in clinical trials revealed significant improvements in renal function and cardiovascular risk leading to superior survival. Despite these proven benefits higher rates…
2016 American Transplant Congress
Real Time Assessment of Kidney Transplant Indication Biopsies by Microarrays: First Results of the INTERCOMEX Study.
P. Halloran,^1,2 J. Reeve,¹ INTERCOMEX Study Group.
¹University of Alberta, Edmonton, Canada; ²ATAGC, Edmonton, Canada.
Oncology uses central molecular tissue assessment (MTA) to guide management but the potential of this approach in transplantation is not known. We undertook a prospective…
2016 American Transplant Congress
Ageing as a Barrier to Transplant Tolerance.
J. Kim, R. Stott, H. Deirawan, L. Kojima, L. Washburn, G. Zhao, H. Yeh, J. Markmann.
Surgery/Transplant, Massachusetts General Hospital, Harvard Medical, Boston, MA.
We recently demonstrated that ageing also impedes development of transplantation tolerance. Unlike their young counterparts (8-12 weeks of age) aged male recipients (greater than 12…
2016 American Transplant Congress
Proteoforms: Novel Biomarkers for Acute Rejection in Liver Transplant Recipients.
J. Levitsky,¹ T. Toby,¹ K. Kim,¹ I. Ntai,¹ A. Demetris,² M. Abecassis,¹ P. Thomas,¹ N. Kelleher.¹
¹Northwestern, Chicago; ²UPMC, Pittsburgh.
Background: Biomarker profiles diagnostic of acute rejection (AR) in liver transplant (LT) recipients could enhance the diagnosis and management of recipients. Our aim was to…
2016 American Transplant Congress
An Improved Method for the Evaluation of Microvascular Inflammation in Renal Allograft Biopsies.
M. Rooney,¹ Z. Ping,² D. Samarapungavan,³ R. Hennigar.⁴
¹Incyte Diagnostics, Spokane Valley, WA; ²Pathology, Beaumont Hospitals, Royal Oak, MI; ³Nephrology, Beaumont Hospitals, Royal Oak, MI; ⁴Nephropathology Associates, Little Rock, AR.
Background: Microvascular inflammation (MVI), assessed as glomerulitis (g) + peritubular capillaritis (ptc), is associated with T cell mediated (CMR) and antibody mediated (AMR) allograft rejection.…
2016 American Transplant Congress
A Non-Invasive Blood Transcriptional Assay, Ksort, Monitors Alloimmune Response in the Sailor Randomized Multicenter Trial.
J. Ekberg,¹ B. Jespersen,² K. Skov,² M. Sarwal,³ T. Sigdel,³ S. Hsieh,³ P. Lindner.¹
¹Transplantation, Sahlgrenska University Hospital, Gothenburg, Sweden; ²Nephrology, Skejby Hospital, Aarhus, Denmark; ³Surgery, University of California, San Francisco.
Non-invasive diagnosis and prediction of acute rejection (AR) is a critical unmet need. A In a randomized multicenter trial of 222 renal transplant recipients a…
2016 American Transplant Congress
Soluble Fibrinogen-Like Protein 2 Regulates Differentiation and Enhances Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Allograft Immunity.
C. Yang,^1,4 L. Wang,³ R. Rong,^2,4 T. Zhu,^2,4 M. Xu.^2,4
¹Plastic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China; ²Urology, Zhongshan Hospital, Fudan University, Shanghai, China; ³Biomedical Research Center, Zhongshan Hospital, Fudan University, Shanghai, China; ⁴Shanghai Key Laboratory of Organ Transplantation, Shanghai, China.
Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an important…
2016 American Transplant Congress
Surveillance Biopsy Findings with Alemtuzumab (ALZ) Induction in Kidney Transplantation.
H. Madariaga,¹ R. Ugarte,¹ C. Drachenberg,² N. Costa,¹ B. Thomas,¹ J. Bromberg,³ M. Weir,¹ A. Haririan.¹
¹Department of Medicine, University of Maryland Medical Center, Baltimore, MD; ²Department of Pathology, University of Maryland Medical Center, Baltimore, MD; ³Department of Surgery, University of Maryland Medical Center, Baltimore, MD.
The risk of subclinical histological changes in renal allografts with ALZ induction is not well defined. Hence, we performed a retrospective analysis of 527 surveillance…
2016 American Transplant Congress
Acute Rejection: A Major Cause of Death-Censored Kidney Allograft Failure.
M. Alkadi,¹ J. Kim,¹ C. Hartono,² M. Aull,¹ T. Muthukumar.¹
¹Weill Medical College of Cornell University, New York; ²The Rogosin Institute, New York.
Introduction:The role of acute rejection as a cause of kidney allograft failure is not well defined in the current era of immunosuppression. We analyzed the…
2016 American Transplant Congress
Treatment for AMR and DSA: A Center Based Review of Pediatric Orthotopic Heart Transplant Recipients.
D. Drogalis-Kim,¹ M. Hickey,² J. Alejos,¹ E. Reed,² N. Halnon.¹
¹Department of Pediatric Cardiology, UCLA, Los Angeles, CA; ²Department of Immunogenetics, UCLA, Los Angeles, CA.
PURPOSE: The aim of this study was to retrospectively analyze the clinical course of pediatric orthotopic heart transplant patients diagnosed with antibody mediated rejection (AMR+)…