ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2016 American Transplant Congress

    Graft Survival in Sensitized and Non-Sensitized Patients: Role of the Combination of Donor-Specific Antibodies and Acute Rejection.

    P. Souza,1 A. Aguirre,1 G. Bezerra,2 H. Rodrigues,2 F. Agena,1 D. David,1 F. de Paula,1 E. David-Neto,1 M. Castro.1

    1Renal Transplant Service, Hospital das Clínicas de São Paulo, Sao Paulo, Brazil; 2Immunology Laboratory, Instituto do Coração (InCor), Sao Paulo, Brazil.

    Background: Sensitized (S) patients have higher risk for acute rejection (AR), especially ABMR. DSA is a risk fator for ABMR, however, its impact on AR…
  • 2016 American Transplant Congress

    A Retrospective Analysis of Rabbit Antithymocyte Globulin Dosing, MELD, Race, and Weight on Infection and Rejection Rates in Liver Transplantation.

    R. Imai, U. Wang.

    Department of Pharmacy, Stanford Health Care, Stanford, CA.

    INTRODUCTION: Rabbit antithymocyte globulin (rATG) use in liver transplantation is uncommon. At our center, induction therapy is comprised of rATG dosed at 1 – 2…
  • 2016 American Transplant Congress

    Durable Clinical and Immunologic Advantage of Living Donor Liver Transplantation (LDLT) in Children.

    E. Przybyszewski,1 S. Lobritto,1 M. Martinez,1 J. Vittorio,1 A. Fox,1 B. Samstein,2 T. Kato,1 A. Griesemer,1 J. Emond.1

    1Columbia University Medical Center, New York, NY; 2Weill Cornell Medical College, New York, NY.

    Purpose:Despite good results, only 10% of liver transplants in children in the US are from living donors. In addition to optimal timing and graft quality,…
  • 2016 American Transplant Congress

    Differential Regulation of the Microvascular Endothelial Cell Mediated Allogeneic CD4+ T Cell Response by Anti-HLA-DR and -DQ Alloantibodies in an Inflammatory Context.

    N. Mooney,1,2 A. Cross,1,2 J. Lion,1,2 A. Haziot,1,2 D. Glotz.1,2,3

    1INSERM UMRS 1160, Institut Universitaire d'Hématologie, Paris, France; 2Université-Paris-Diderot, Sorbonne Paris Cité, Paris, France; 3Service de Néphrologie et Transplantation, Hôpital Saint Louis, Paris, France.

    This study examines the basic mechanisms by which high levels of circulating HLA class II donor-specific-antibodies can contribute to microvasculature damage in chronic antibody mediated…
  • 2016 American Transplant Congress

    Kidney Transplantation in HIV Patients: Effect of Race on the Choice of Anti-Thymocyte Globulin Induction Immunosuppression.

    M. Casey, T. Aijaz, X. Wen, S. Rehman, A. Santos, E. Thomas, K. Andreoni, K. Womer.

    University of Florida, Gainesville, FL.

    Introduction: HIV positive status is a well-known risk factor for acute rejection (AR) in kidney transplant recipients (KTR). In the United States, the majority of…
  • 2016 American Transplant Congress

    A Molecular Biopsy Test for Probability of Non-Adherence.

    P. Halloran,1,3 G. Einecke,2 J. Reeve.1

    1ATAGC, Edmonton, AB, Canada; 2Hannover Medical School, Hannover, Germany; 3Department of Medicine, University of Alberta, Edmonton, AB, Canada.

    Afferent arteriolar hyalinosis (ah-score) in renal transplant biopsies increases with time of biopsy-post-transplant (TxBx), reflecting calcineurin inhibitor drug effects, donor aging, and progressive glomerular diseases.…
  • 2016 American Transplant Congress

    Association of Ultrastructural Changes in Renal Allograft Biopsies with Antibody-Mediated Rejection (AMR) and Graft Outcomes.

    A. Haririan,1 M. Chaudhry,2 J. Papadimitriou,2 N. Costa,1 B. Thomas,1 M. Mavanur,1 R. Ugarte,1 C. Cangro,1 C. Drachenberg.2

    1Dept of Medicine, Unniversity of Maryland, Baltimore, MD; 2Dept of Pathology, University of Maryland, Baltimore, MD.

    The role of electron microscopy (EM) in diagnosis of AMR is not well-defined. We sought to examine the EM findings in 796 biopsies from 622…
  • 2016 American Transplant Congress

    The Effect of Donor-Recipient Relationship on the Immunologic Outcome in Living Kidney Transplantation.

    D. Khadzhynov, F. Halleck, L. Lehner, M. Duerr, J. Waiser, K. Budde, O. Staeck.

    Nephrology, Charite Campus Mitte, Berlin, Germany.

    Background. Presensitization and degree of HLA-matching influences immunologic outcome and kidney graft survival. Thus the donor-recipient relationship may influence incidence of immunologic events and outcome…
  • 2016 American Transplant Congress

    A2 Kidneys into B Recipients: Is Postoperative Anti-A1 Titer Monitoring Useful?

    A. DeMers, R. Forbes, D. Moore, K. Smith, D. Shaffer.

    Kidney and Pancreas Transplantation, Vanderbilt University Medical Center, Nashville, TN.

    Background: Since the introduction of the new Kidney Allocation System in December 2014, our center implemented a protocol for transplanting A2 kidneys into B recipients…
  • 2016 American Transplant Congress

    Transcriptome Profiles in Peripheral Blood of Kidney Graft Recipients.

    J.-W. Seo,1 H. Moon,1 Y.-G. Kim,1 K.-H. Jeong,1 S.-J. Ihm,2 J.-Y. Moon,1 S.-H. Lee.1

    1Division of Nephrology, Department of Internal Medicine, Kyung Hee University College of Medicine, Seoul, Republic of Korea; 2Department of Pathology, Kyung Hee University College of Medicine, Seoul, Republic of Korea.

    The discovery of sensitive noninvasive diagnosis and the development of immune management in the renal allograft recipients are required for long-term graft survival. Although the…
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