Articles tagged "Rejection"

2016 American Transplant Congress
MicroRNAs in Urinary Sediments as Non-Invasive Tool to Detect Acute Rejection After Kidney Transplantation.
E. Gielis,^1,2 J. Anholts,² H. de Fijter,³ I. Bajema,⁴ F. Claas,² M. Eikmans.²
¹Laboratory of Experimental Medicine and Pediatrics, University of Antwerp, Antwerp, Belgium; ²Immunohematology, LUMC, Leiden, Netherlands; ³Nephrology, LUMC, Leiden, Netherlands; ⁴Pathology, LUMC, Leiden, Netherlands.
MicroRNAs in urine are suitable targets for non-invasive detection of acute rejection (AR), since they represent relatively stable analytes. Indeed, we found that PCR signals…
2016 American Transplant Congress
Plasma Alemtuzumab Levels Show Great Interpatient Variability, but Are Not Associated with Late Acute Rejection in Simultaneous Pancreas-Kidney Recipients.
J. Bank,¹ M. Mallat,¹ C. Jol-van der Zijde,² R. Bredius,² P. van der Boog,¹ A. Braat,³ J. Ringers,³ M. Reinders,¹ J. de Fijter.¹
¹Nephrology, LUMC, Leiden, Netherlands; ²Pediatrics, LUMC, Leiden, Netherlands; ³Surgery, LUMC, Leiden, Netherlands.
Introduction: Alemtuzumab induction followed by a steroid-free, tacrolimus (Tac) and mycophenolate mofetil (MMF) based regimen effectively prevented acute rejection after simultaneous pancreas-kidney transplantation (SPKT). Acute…
2016 American Transplant Congress
Post-Transplant Reduction of Long Lived Plasma Cells from Peripheral Circulation Is Associated with Acute Rejection in Kidney Transplant Recipients.
R. Minz,¹ R. Dhital,² M. Minz,² R. Nada,³ A. Sharma,² S. Singh,² D. Kenwar.²
¹Immunopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India; ²Renal Transplant Surgery, Post Graduate Institute of Medical Education and Research, Chandigarh, India; ³Histopathology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Introduction:Plasma cells (PC) are usually defined functionally as antibody secreting cells (ASC). Depending upon their life span, they could either be short lived or long…
2016 American Transplant Congress
Myeloid-Derived Suppressor Cells (MDSC) Accumulate in Intestinal Transplant (IT) Patients.
S. Okano,¹ K. Hashimoto,¹ K. Abu-Elmagd,¹ J. Fung,¹ D. Kish,² K. Keslar,² B. Min,² R. Fairchild,² C. Miller.¹
¹Transplant Center, Cleveland Clinic, Cleveland, OH; ²Department of Immunology, Lerner Reserch Center, Cleveland Clinic, Cleveland, OH.
[Background] IT is an efficacious treatment for chronic intestinal failure. Recent advance of immunosuppressive regimens have decreased the rejection rate and improved patient survival. The…
2016 American Transplant Congress
Assessment of Postoperative Glycemic Control in Orthotopic Heart Transplant Recipients.
J. Glick Frasiolas, J. Matthew, D. Tsapepas.
NewYork-Presbyterian Hospital, Columbia University, New York.
Hyperglycemia may occur after solid organ transplantation because of stress, immunosuppressants, and diabetes mellitus. Glycemic control has been shown to decrease morbidity and mortality in…
2016 American Transplant Congress
Inflammation Amplifier, a Chemokine Inducer in Non-Immune Cells in Kidney Transplantation Graft.
H. Higuchi,^1,2 H. Bando,² J. Jing-Jing,² T. Atsumi,² D. Iwami,¹ K. Morita,¹ N. Shinohara,¹ M. Murakami.²
¹Renal and Genitourinary Surgery, Hokkaido University, Sapporo, Japan; ²Molecular Neuroimmunology, Institute of Genetic Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.
Introduction: Inflammation amplifier (IA), a local chemokine inducer in non-immune cells is induced by the simultaneous activation of NFκB and STATs (IL-17, TNFα, and IL-6)…
2016 American Transplant Congress
Age Adapted Immunosuppression for Elderly Kidney Allograft Recipients: Balancing Risks for Cancer versus Rejection.
F. Jackson-Spence,¹ H. Gillott,¹ S. Tahir,¹ F. Evison,² J. Nath,³ A. Sharif.³
¹University of Birmingham Medical School, Birmingham, United Kingdom; ²Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom; ³Queen Elizabeth Hospital Birmingham, Birmingham, United Kingdom.
Introduction Cancer is a growing cause of morbidity and mortality after kidney transplantation, driven by immunosuppression. Age is one of the strongest risk factors for…
2016 American Transplant Congress
Factors Mediating Kidney Rejection in Patients of Simultaneous Liver-Kidney Transplants.
R. Dong, A. Tambur, L. Gallon, J. Levitsky.
Northwestern, Chicago, IL.
BACKGROUND & AIM: Kidney grafts in simultaneous liver-kidney (SLK) recipients are considered to be immunologically protected due to hepatic tolerance, although recent studies have alternatively…
2016 American Transplant Congress
Benefit of Protocol Biopsies in Pediatric Kidney Transplant Patients.
M. Nazario, O. Moussa, S. Self, K. Twombley.
Medical University of South Carolina, Charleston.
BackgroundMuch debate exists over the utility of protocol biopsies for pediatric kidney transplant recipients. While there is a growing amount of literature on the utility…
2016 American Transplant Congress
First Clinical Experience with Belatacept in 3 Hand Transplanted Patients.
J. Grahammer,¹ B. Zelger,² B. Zelger,³ M. Ninkovic,¹ A. Muehlbacher,⁴ D. Oefner-Velano,¹ S. Schneeberger,¹ A. Weissenbacher.⁵
¹Viceral, Thoracic and Transplant Surgery, Innsbruck Medical University, Innsbruck, Austria; ²Dermatology and Venerology, Innsbruck Medical University, Innsbruck, Austria; ³Pathology, Innsbruck Medical University, Innsbruck, Austria; ⁴Department of Blood Group Serology and Transfusion Medicine, Innsbruck Medical University, Innsbruck, Austria; ⁵Oxford Transplant Centre, Nuffield Department of Surgical Sciences, Oxford University, Oxford, United Kingdom.
Study purposeBelatacept (CTLA4Ig) is an emerging treatment in solid organ transplantation. Effects on the development of donor specific antibodies (DSA) as well as its clinical…