2016 American Transplant Congress
Relationship Between Changes in Brain Natriuretic Peptide Levels and Cardiac Allograft Rejection Early After Heart Transplantation.
1University of Colorado, Aurora, CO; 2Vanderbilt University, Nashville, TN.
Endomyocardial biopsies (EMBs) are routinely used to detect cardiac allograft rejection after heart transplantation (HTx), but they are invasive and costly. Serial changes in brain…2016 American Transplant Congress
Tacrolimus as a Tool for Intracellular Assessment of von Willebrand Factor Production by Activated Human Glomerular Endothelial Cells.
Renal Division, University Health Center (CHU) of Quebec, Laval University, Quebec, QC, Canada.
Background: Von Willebrand factor (vWF) is a prothrombotic mediator stored in intracytoplasmic granules within endothelial cells and is released by endothelial exocytosis, leading to microangiopathic…2016 American Transplant Congress
Allograft TLR4 Receptor Signaling Induces Specific Early Inflammatory Events in Promotes Allografts Subjected to Prolonged Cold Ischemic Storage.
Dept. Immunology and Glickman Urological Institute, Cleveland Clinic, Cleveland, OH.
Engagement of Toll-like receptors (TLR) by endogenous danger-associated molecular pattern ligands contributes to the intensity of tissue inflammation, including the inflammation generated during ischemia-reperfusion injury…2016 American Transplant Congress
The Impact of Microvascular Inflammation (MVI) in Kidney Transplant Biopsies (KTxBx) Is Independent of Time Post-Transplant.
Detection of MVI in a KTxBx, often associated with antibody mediated rejection, is associated with a poor prognosis for kidney graft survival. However most information…2016 American Transplant Congress
Acute Rejection, New-Onset Diabetes After Transplant and Transplant Outcomes in Pediatric Kidney Recipients: Analysis of the Organ Procurement and Transplant Network/United Network for Organ Sharing (OPTN/UNOS) Database.
Nephrology, UCLA, Los Angeles, CA.
Introduction Our objective was to identify the associations of new-onset diabetes after transplant (NODAT) and acute rejection (AR) in predicting patient mortality and transplant failure…2016 American Transplant Congress
A P2X7R Mutation with Hypermetabolic T Cells, Th1/Th17 Skewing and Reduced Cardiac Allograft Survival.
Background. The purinergic receptor-7 (P2X7R), primarily expressed on lymphocytes, senses ATP released extracellularly during cell damage and regulates T cell activation.Methods. In 640 heart transplant…2016 American Transplant Congress
miR-21 in Chronic Allograft Vasculopathy.
Background. Heart transplantation is the most effective therapy to prolong life expectancy in patients with end-stage heart failure. However, despite much progress in the field,…2016 American Transplant Congress
A Sustained Viral Response Achieved with Sofosbuvir/Ledipasvir May Increase the Incidence of Acute Cellular Rejection Post Liver Transplantation.
Transplant Surgery, New York University Langone Medical Center, New York, NY.
Acute cellular rejection following liver transplantation has decreased in incidence with the use of potent immunosuppressive agents, affecting less than 25 percent of liver transplantation…2016 American Transplant Congress
De Novo Anti-HLA DSA Characteristics and Subclinical Antibody Mediated Kidney Allograft Injuries.
Nagoya daini red cross hospital, Nagoya, Japan.
Background It has been reported that de novo donor-specific HLA antibody (dn DSA) production is associated with chronic antibody-mediated rejection (CAMR) which leads to poor…2016 American Transplant Congress
MicroRNAs in Urinary Sediments as Non-Invasive Tool to Detect Acute Rejection After Kidney Transplantation.
MicroRNAs in urine are suitable targets for non-invasive detection of acute rejection (AR), since they represent relatively stable analytes. Indeed, we found that PCR signals…
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