2022 American Transplant Congress
Safety and Efficacy of a Probiotic Protocol to Reduce Perioperative Infection After Liver Transplantation
University of Wisconsin Health, Madison, WI
*Purpose: Evaluate efficacy and safety of a probiotic preparation to reduce perioperative infection in patients undergoing liver transplant surgery*Methods: Adult patients receiving liver transplantation from…2022 American Transplant Congress
Transjugular Intrahepatic Portosystemic Shunt Placement is Associated with Increased All-Cause and Cardiac Mortality in Those Undergoing Liver Transplant for Nonalcoholic Steatohepatitis
*Purpose: Since the effect of transjugular intrahepatic portosystemic shunt (TIPS) on post LT outcomes is not well understood, we undertook this analysis of a large…2022 American Transplant Congress
Antibody-Mediated Rejections with C1q-binding and without C1-Binding Donor-Specific Antibodies in Kidney Transplantation
Asan Medical Center, Seoul, Korea, Republic of
*Purpose: All donor-specific antibodies (DSAs) are not clinically relevant. Therefore, the C1q assay has been recently used, but its clinical meaning and usefulness should be…2022 American Transplant Congress
Correlating Histology, Immunohistochemical, & Serologic Data in Heart Transplant Recipients: Implications for Molecular Diagnostic Assays
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: The ISHLT classification of rejection in heart allograft biopsies is independent of DSA status. There is only limited data on the prevalence of DSA…2022 American Transplant Congress
Discrepancy Rates Between Histology (HIST) and Molecular Diagnosis (MDX) of T-cell Mediated Rejection (TCMR) Depend on Choice of Bioinformatics Pipeline
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: HIST based treatment of TCMR has played a key role in the reduction of its incidence to historic lows of ~10%. MDX methods developed…2022 American Transplant Congress
De Novo Donor-Specific Antibody Development with Mycophenolate versus Azathioprine in Lung Transplant Recipients
*Purpose: The effect of mycophenolate mofetil (MMF) or azathioprine (AZA) immunosuppression (ISN) regimens on de novo donor specific antibody (DSA) formation in lung transplant recipients…2022 American Transplant Congress
Gene Expression Profiles of Peritubular Capillarits in Chronic Antibody-Mediated Rejection
*Purpose: Antibody-mediated rejection (ABMR) is one of the most significant contributors to late graft loss. Hallmark characteristics include peritubular capillaritis (ptc) and glomerulitis (g). Diffuse…2022 American Transplant Congress
Biopsy and Blood Gene Expression Profiles Distinguish Injury, Subclinical and Clinical Rejection in Kidney Transplant Recipients
1Scripps Health, La Jolla, CA, 2Northwestern University, Chicago, IL
*Purpose: We analyzed serial gene expression profiles in paired blood and biopsies from kidney transplant recipients phenotyped with a comprehensive clinical algorithm. We compared disease…2022 American Transplant Congress
Influence of Converting Kidney Transplant Recipients with High Tacrolimus Variability to the Once Daily LCP Tac Formulation
Med Univ of South Carolina, Charleston, SC
*Purpose: Tacrolimus (Tac) is the cornerstone of immunosuppression used in kidney transplant recipients (KTRs). Tac high variability, low time in therapeutic range and non-adherence are…2022 American Transplant Congress
Enhanced Histological Yield and Actionable Findings When Biopsy is Guided by Donor-Derived Cell-Free DNA (dd-cfDNA)
*Purpose: Implementation of molecular biomarkers in kidney transplantation has expanded the amount of information available to clinicians before deciding to pursue biopsy. We evaluated how…
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