2022 American Transplant Congress
Recipient Neutrophil Production of Myeloperoxidase is Required for NK Cell Activation During Acute Antibody Mediated Allograft Rejection
*Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched A/J kidney allografts and are required for rejection of…2022 American Transplant Congress
The Impact of Food Insecurity on Pediatric Kidney Transplant Outcomes
Pediatric Nephrology, Lurie Children's Hospital, Chicago, IL
*Purpose: We previously demonstrated a prevalence of food insecurity (FI) of 26.7% at our institution, in a pilot study of 45 pediatric kidney transplant (pedsKTx)…2022 American Transplant Congress
Donor-Derived IL-33 Plays a Critical Role in Lung Allograft Acceptance
*Purpose: IL-33 is considered an alarmin secreted in response to tissue damage. While it is elaborated by the lung allograft as part of ischemia-reperfusion injury…2022 American Transplant Congress
The Correlation of Dd-cfdna and Donor Specific Antibodies in Kidney Transplant Recipients
Johns Hopkins Hospital, Baltimore, MD
*Purpose: Donor derived cell free DNA (dd-cfDNA) is increasingly being utilized to discern the presence of rejection in kidney transplant recipients (KTRs). There continues to…2022 American Transplant Congress
Safety of Stimulant Use in Heart Transplant Recipients
*Purpose: FDA-approved prescribed stimulants are purported to increase risk of cardiovascular (CV) adverse events, particularly arrhythmias and sudden cardiac death. Debate exists regarding the safety…2022 American Transplant Congress
The Relative Association of Clinical Variables and Histologic Lesions with Molecular Rejection in Kidney Transplant Biopsies
*Purpose: Availability of molecular assessment (MMDx) independent of conventional variables (time, clinical, histologic, and HLA antibody) presents an opportunity to re-assess the relative strength of…2022 American Transplant Congress
Surveillance of Donor-Derived Cell-Free DNA Throughout Treatment of Acute Rejection in Pediatric Renal Transplant Recipients
*Purpose: Donor-derived cell-free DNA (dd-cfDNA) is a dynamic plasma biomarker for allograft rejection with limited data in pediatric renal transplant recipients and few reports describing…2022 American Transplant Congress
The Natural History of De Novo DSA After Kidney Transplantation
*Purpose: De novo donor-specific antibodies(dnDSA) are key in the diagnosis of antibody-mediated rejection(ABMR) and are related to graft loss(GL). Luminex® provides semi-quantitative information with the…2022 American Transplant Congress
Data-Driven Clustering Distinguishes Infection from Rejection During Hospital Admissions Following Pediatric Lung Transplantation
*Purpose: When lung transplantation patients are admitted with respiratory symptoms, distinguishing between episodes of infection and rejection is central to determining immunosuppressive management.*Methods: Data comprising…2022 American Transplant Congress
Development of a Dynamic Map of Peripheral Myeloid Cells Associated with Acute Rejection of Vascularized Composite Tissue Allografts
*Purpose: Myeloid cells are involved in early alloactivation in response to organ allografts and can initiate acute rejection. The heterogeneity of myeloid populations and the…
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