2022 American Transplant Congress
Hypomethylated Regulatory Regions in Immune Signaling Genes Characterize Rejection Prone Pediatric Liver Transplant (LT) Recipients
*Purpose: Transcriptional regulation of LT rejection may reveal novel predictive and therapeutic targets. To identify signaling pathways which are differentially regulated by DNA methylation in…2022 American Transplant Congress
Use of Everolimus and Reduced Calcineurin Inhibitors in Bk Nephropathy: Insights from Follow-Up and Surveillance Biopsies
Cleveland Clinic, Cleveland, OH
*Purpose: BK virus-associated nephropathy (BKVAN) is a clinically important entity that results in an allograft loss in kidney transplant recipients (KTRs). Mammalian target of rapamycin…2022 American Transplant Congress
Non-HLA Autoantibodies: The Hidden Offenders to Double the Trouble
*Purpose: There is emerging evidence suggesting non-HLA autoantibodies triggered after the graft injury. Here, we report 3 cases where non-HLA autoantibodies were positive after 3…2022 American Transplant Congress
Comprehensive Profiling of Monocytes During Cellular (TCMR) or Mixed Antibody-Mediated Rejection (ABMR) After Kidney Transplantation
*Purpose: Monocytes play an important role in the immune defense by initiating adaptive immunity. They are heterogeneous, plastic, and present different subsets: classical (CD14++CD16-), intermediate…2022 American Transplant Congress
Development and Validation of an Integrative DD-CFDNA System to Predict Allograft Rejection: A Population Based Study
Paris Translational Center for Organ Transplantation, Paris, France
*Purpose: Post-transplantation patient care requires development and validation of non-invasive biomarkers to improve allograft monitoring and prevention from unnecessary and costly biopsies. Reports have suggested…2022 American Transplant Congress
Racial Differences in the Predictability of Donor-Derived Cell-Free DNA Among Renal Transplant Recipients
1Rush University Medical Center, Chicago, IL, 2CareDx, Brisbane, CA
*Purpose: Donor-Derived Cell-Free DNA (dd-cfDNA) is used to monitor for allograft rejection following renal transplantation. Baseline dd-cfDNA is higher in African American (AA) patients compared…2022 American Transplant Congress
Steroid-Free Living Donor Liver Transplantation Using Rabbit Antithymocyte Globulin Induction Reduces Incidence of Acute Cellular Rejection
*Purpose: The efficacy of steroid-free immunosuppression protocols using rabbit antithymocyte globulin (RATG) induction with tacrolimus minimization has previously been described in deceased donor liver transplantation.…2022 American Transplant Congress
Peripheral Blood Immune Cell Profiles of Corneal Transplant with and without Acute Rejection
*Purpose: Acute rejection (AR) of allogeneic corneal transplantation (CT) has a profound effect on subsequent graft survival, indicating that immunological damage is often not fully…2022 American Transplant Congress
A Three-gene Peripheral Blood Potential Diagnosis Signature Associated With Autophagy For Antibody-mediated Rejection In Renal Transplantation
Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
*Purpose: Antibody-mediated rejection (AMR) is emerging as a major cause of graft loss in renal transplantation. Nowadays, non-invasive diagnosis of AMR with high accuracy is…2022 American Transplant Congress
Technology Enabled And Molecular Monitoring Of The Allograft And Transplant Recipient Study
*Purpose: With the widespread availability of smart mobile devices, mobile health (mHealth) provides the opportunity to reach wide array of patients. Readmission rates as high…
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