Articles tagged "Rejection"

2017 American Transplant Congress
The Effect of Histological Isolated Endarteritis and Solid Endoarteritis Combined with CD20 Positive B Cell Infiltration Appeared in Acute Cellular Rejection on Kidney Allograft Survival.
R. Wang, Y. Jiang, J. Wu, W. Peng, H. Huang, J. Chen.
Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hanghzou, Zhejiang, China
BackgroundEndarteritis post renal transplantation is regarded as T-cell mediated acute rejection by Banff classification. Recently, results from DNA microarrays suggested that endovasculitis did not represent…
2017 American Transplant Congress
Clinical and Histopathologic Features of Antibody Mediated Rejection (ABMR) in Highly Sensitized (HS) vs Non-Sensitized (NS) Pediatric Renal Transplant Recipients.
J. Steggerda, I. Kim, M. Haas, X. Zhang, A. Wang, H. Pizzo, E. Kamil, S. Jordan, D. Puliyanda.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Background: The presence of preformed donor-specific antibody (pDSA) in HS pts and development of de-novo DSA (dnDSA) in NS patients are risk factors for ABMR.…
2017 American Transplant Congress
The Innate Immune-System May Play an Enhanced Role in Acute Cellular Rejection in Patients on Belatacept-Based Immunosuppression.
D. Dobi,¹ Q. Tang,² S. Chandran,³ F. Vincenti,³ Z. Laszik.¹
¹Department of Pathology, University of California, San Francisco, San Francisco, CA; ²Department of Surgery, Division of Transplant Surgery, University of California, San Francisco, San Francisco, CA; ³Department of Medicine, Division of Nephrology, University of California, San Francisco, San Francisco, CA
Purpose. The incidence of acute cellular rejection (ACR) in kidney transplant patients on Belatacept (Bela-ACR) is higher than in those with CNI-based regimens (CNI-ACR). However,…
2017 American Transplant Congress
Binding of Antigens by Its Specific Antibodies Results in Exosome Formation Leading to Rejection of Syngeneic Murine Cardiac Grafts.
M. Sharma, W. Liu, M. Gunasekaran, S. Bansal, T. Mohanakumar.
Norton Thoracic Institute, St. Joseph's Hospital and Medical Center, Phoenix
Background: Antibody binding to its antigen can activate complement cascades leading to cell death. In addition, it can activate intracellular signals leading to rejection of…
2017 American Transplant Congress
Impact of Bariatric Surgery on Risk of Organ Rejection Among Solid Organ Transplant Recipients.
M. Soghikian, D. Gregory, J. Wilcox, A. Shetty, D. Ladner, L. VanWagner.
Medicine, Northwestern University, Chicago, IL; Surgery, Northwestern University, Chicago, IL
Background: Obesity is a common condition that contributes to organ failure. Bariatric surgery is an effective surgical therapy for obesity and has been performed both…
2017 American Transplant Congress
A Combination of Anti-CD40L-Ab, Rapamycin, and Donor Apoptotic Cells Prolongs Allogeneic Pancreatic Islet Survival in Sensitized Mice by Regulating Memory Responses.
A. Dangi,¹ H.-K. Kang,¹ X. Zhang,^2,3 X. Luo.^1,2,3
¹Nephrology and Hypertension, Northwestern University, Chicago, IL; ²Comprehensive Transplant Center, Northwestern University, Chicago, IL; ³Surgery, Northwestern University, Chicago, IL
Accelerated rejection of allografts has been a clinical challenge in solid organ transplantation particularly in sensitized recipients with donor-specific antibodies (DSA) and memory cell repertoires.…
2017 American Transplant Congress
Gene Expression Signature of Subclinical Allograft Kidney ABMR Compared to Clinical ABMR.
O. Aubert,¹ C. Lefaucheur,¹ S. Higgins,¹ L. Hidalgo,² J. Duong Van Huyen,¹ D. Viglietti,¹ X. Jouven,¹ D. Glotz,¹ C. Legendre,¹ P. Halloran,² A. Loupy.¹
¹Paris Translational Research Center for Organ Transplantation, Paris, France; ²ATAGC, Edmonton, France
BackgroundAntibody-mediated rejection (ABMR) is characterized by a heterogeneous presentation. It occurs in clinically stable patients (sABMR) or in patients with allograft dysfunction (ABMR), but only…
2017 American Transplant Congress
Impact of Cytokine Gene Polymorphism on Clinical Outcome of Renal Transplantation.
I. Pérez-Flores,¹ J. Santiago,² A. Moreno Dela Higuera,¹ N. Calvo,¹ B. Rodriguez-Cubillo,¹ E. Urcelay,² A. Shabaka,¹ M. Calvo,¹ A. Sanchez-Fructuoso.¹
¹Nephrologist, Hospital Clinico San Carlos, Madrid, Spain; ²UGC Immunology, Hospital Clinico San Carlos and Instituto de Investigación Sanitaria (IdISSC), Madrid, Spain
Cytokine production is subject to genetic regulation, in such a way that gene polymorphisms at the level of promoter or coding regions can alter their…
2017 American Transplant Congress
Impact of Complement Component 3 Single Nuclear Polymorphisms on Renal Transplant Recipients with Antibody-Mediated Rejection.
Z. Wang, Z. Han, J. Tao, R. Tan, M. Gu.
Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Impact of complement component 3 single nuclear polymorphisms on renal transplant recipients with antibody-mediated rejectionZijie Wang, Zhijian Han, Jun Tao, Ruoyun Tan, Min GuDepartment of…
2017 American Transplant Congress
Incidence of Donor-Specific Anti-HLA Antibodies in Non-HLA Sensitized Patients Given Tacrolimus Once or Twice Daily During the First Two Years Post-Transplantation.
N. Kamar, V. Hajj, I. Ferrandiz, E. Younes, L. Esposito, A. Hébral, A. Del Bello.
Department of Nephrology and Organ Transplantation, Toulouse University Hospital, Toulouse, France
Donor-specific anti-HLA antibody (DSA)-mediated rejection (AMR) is a main cause of graft loss after kidney transplantation. Non-adherence is a risk factor for AMR and graft…