Articles tagged "Rejection"

2017 American Transplant Congress
Repeat Biopsies After the Diagnosis of BK Virus Associated Nephropathy: Importance of Integrating Clinical and Pathological Findings.
C. Drachenberg,¹ J. Papadimitriou,¹ R. Ugarte,² M. Mavanur,² B. Thomas,² C. Cangro,² N. Costa,² M. Weir,² A. Haririan.²
¹Pathology, University of Maryland School of Medicine, Baltimore, MD; ²Medicine, University of Maryland School of Medicine, Baltimore, MD
Early diagnosis of PV nephropathy(PyVAN) leads to overall improvements in the short term but sclerosing sequelae and risk for rejection (mainly antibody mediated) contribute to…
2017 American Transplant Congress
Donor-Specific B Cell Responses: Predicting the Future of Kidney Transplants.
M. Cascalho,¹ E. Farkash,² L. Adam,¹ M. Samaniego,³ J. Platt.
¹Surgery, University of Michigan, Ann Arbor; ²Pathology, University of Michigan, Ann Arbor; ³Internal Medicine, University of Michigan, Ann Arbor
Allogeneic cell and tissue transplants nearly always evoke B cell responses ascertainable by detecting donor-specific antibodies (DSA) in the circulation of the recipient. DSA are…
2017 American Transplant Congress
Gut Microbial Metabolite Improves Function and Prolongs Kidney Allograft Survival in Mice.
H. Wu,^1,2 T. Kwan,¹ Y. Loh,¹ X. Chen,¹ L. Macia,^2,3 S. Alexander,^2,4 S. Chadban.^1,2
¹Kidney Node Laboratory, The Charles Perkins Centre and Renal Medicine, Sydney Medical School and Royal Prince Alfred Hospital, Sydney, Australia; ²University of Sydney, Sydney, Australia; ³Nutritional Immunometabolism Lab, The Charles Perkins Centre, Sydney Medical School, Sydney, Australia; ⁴Nephrology Department, The Children Hospital at Westmead, Sydney, Australia
To determine the impact of dietary administration of the gut microbial metabolite sodium acetate (SA) on kidney rejection and survival in a fully MHC-mismatched murine…
2017 American Transplant Congress
Urinary Proteomic Biomarkers Discovery for Prediction of Acute Rejection in Kidney Transplant Recipients.
H.-Y. Jung, R. Kim, S. Park, J. Park, K. Lee, E. Lee, J.-H. Lim, K. Kim, J.-Y. Choi, J.-H. Cho, S.-H. Park, Y.-L. Kim, C.-D. Kim.
Internal Medicine, Kyungpook National University Hospital, Daegu, Republic of Korea
Background: Early prediction and treatment of acute rejection are crucial in kidney transplant recipients (KTRs) to prevent allograft loss. Changes in the serum and urinary…
2017 American Transplant Congress
Assessment of Donor-Reactive T-Cell Immunity by the Novel Urine Cell-Derived Alloantigen Assay Allows Prediction of Acute Rejection in Renal Transplant Patients.
C. Thieme,¹ B. Weist,¹ A. Müskes,¹ P. Reinke,¹ T. Westhoff,² N. Babel.^1,2
¹BCRT (Berlin-Brandenburg Center for Regenerative Therapies), Berlin, Germany; ²Ruhr University Bochum, Bochum, Germany
Presensitization and donor-specific immunity play a major role in acute and chronic rejection of kidney transplant patients. While assessment of humoral sensitization is well standardised…
2017 American Transplant Congress
Immune Monitoring-Guided Treatment of a Pediatric Patient with Sequential GvHD, Acute Rejection and CMV Infection Following Lung Transplantation.
C. Falk,¹ S. Nicolaus,² M. Carsten,² T. Igor,³ S. Wiebke,³ D. Kerstin,¹ K. Jana,² H. Gesine,² H. Axel,³ W. Gregor.³
¹Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; ²Department of Pediatric Pulmology, Hannover Medical School, Hannover, Deutschland, Germany; ³Department of Cardiothoracic Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Deutschland, Germany
Background: A 17 year old patient with cystic fibrosis (HLA-A11+, CMV-) underwent bilateral sequential lung transplantation (donor: HLA-A32+, CMV+). Immunosuppression (IS) consisted of Tacrolimus, MMF…
2017 American Transplant Congress
Association of Non-HLA Antibodies with Histological Changes of Antibody Mediated Injury in Kidney Transplantation.
N. Leca,¹ I. Gimferrer,² P. Warner,² K. Nelson,² R. Bakthavatsalam,¹ L. Sibulesy,¹ B. Najafian,³ C. Robinson-Cohen,¹ B. Kestenbaum.¹
¹Division of Nephrology, University of Washington, Seattle; ²Bloodworks NW, Seattle
Solid phase assays, particularly single-antigen beads, have substantially increased the sensitivity and accuracy of antibody detection in transplantation. However, donor specific antibodies(DSA) against human leukocyte…
2017 American Transplant Congress
Donor Smoking History Associated with Increased Risk of Death Following Lung Transplantation, but Lower Risk of Bronchiolitis Obliterans Syndrome.
S. Burger, M. Eberlein, J. Keech, E. Arshava, T. Pena, S. Larson, J. Klesney-Tait, K. Parekh.
Cardiothoracic Surgery, University of Iowa, Iowa City, IA
Purpose: The impact of donor smoking history on long term mortality, causes of mortality and the development of bronchiolitis obliterans syndrome (BOS) following lung transplantation…
2017 American Transplant Congress
CD16+ Monocytes and Skewed Macrophage Polarization Towards M2 Type Hallmark Heart Transplant Acute Cellular Rejection.
T. van den Bosch,¹ K. Caliskan,² M. Kraaij,¹ A. Constantinescu,² O. Manintveld,² P. Leenen,³ J. von der Thüsen,⁴ M. Clahsen-van Groningen,⁴ C. Baan,¹ A. Rowshani.¹
¹Internal Medicine and Transplantation, Erasmus University Medical Center, Rotterdam, Netherlands; ²Cardiology, Erasmus University Medical Center, Rotterdam, Netherlands; ³Immunology, Erasmus University Medical Center, Rotterdam, Netherlands; ⁴Pathology, Erasmus University Medical Center, Rotterdam, Netherlands
Purpose: During acute heart transplant rejection, infiltration of lymphocytes and monocytes is followed by endothelial injury and eventually myocardial fibrosis. To date, no information is…
2017 American Transplant Congress
Activation of Inflammation Amplifier in Kidney Graft and Urinary Biomarker for Chronic Rejection.
H. Higuchi,^1,2 D. Iwami,¹ K. Hotta,¹ N. Shinohara,¹ M. Murakami.²
¹Hokkaido University, Renal and Genitourinary Surgery, Sapporo, Hokkaido, Japan; ²Hokkaido University, Molecular Neuroimmunology, Institute of Genetic Medicine, Graduate School of Medicine, Sapporo, Hokkaido, Japan
[Introduction and Objective] Inflammation amplifier (IA), a local chemokine inducer in non-immune cells is induced by simultaneous activation of NFκB and STATs (IL-17, TNFα, and…