ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2017 American Transplant Congress

    Expression of T-Cell Mediated Rejection (TCMR) Associated Genes in Native and Renal Allograft Renal Biopsies with Inflamed Scars (i-IFTA).

    Z. Lyu,1 L. Pang,1 G. Zeng,2 Y. Huang,2 P. Randhawa.2

    1Pathology & Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China; 2Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA

    The presence of i-IFTA in allograft kidney biopsies is a bad prognostic parameter. However, despite the presence of T-cell infiltrates in these lesions there is…
  • 2017 American Transplant Congress

    The Degree of NK Cell Activation Determines the Ability of Donor-Specific Antibodies to Mediate Acute vs. Chronic Rejection of Kidney Allografts.

    T. Yagisawa,1,2 T. Tanaka,1 N. Dvorina,1 A. Valujskikh,1 W. Baldwin 3rd,1 R. Fairchild.1

    1Immunology and Glickman Urological Institute, Cleveland Clinic, Cleveland, OH; 2Urology, Tokyo Women's Medical University, Tokyo, Japan

    While the incidence of antibody-mediated kidney graft rejection has increased, the key cellular and molecular participants underlying this graft injury remain unclear. We have previously…
  • 2017 American Transplant Congress

    Islet Rejection in Autoimmune NOD Mouse Recipients: Implications for Stem Cell Therapies.

    R. Gill,1 M. Coulombe,1 T. Kupfer,1 K. Beard,1 A. Burrack.2

    1Surgery and Immunology, University of Colorado Denver, Aurora, CO; 2University of Minnesota, Minneapolis, MN

    Several efforts are ongoing to use stem cell precursors to generate islet-like tissues suitable for transplantation in autoimmune Type 1 diabetic (T1D) recipients. During the…
  • 2017 American Transplant Congress

    Single Nuclear Polymorphisms of Complement Component 4 and Component 5 in Renal Transplant Recipients with Antibody-Mediated Rejection.

    Z. Wang, Z. Han, J. Tao, R. Tan, M. Gu.

    Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China

    Background: Antibody-mediated rejection (ABMR) is an important cause of allograft dysfunction in short-term and long-term period. The complement component 4 (C4) and component 5 (C5)…
  • 2017 American Transplant Congress

    Tacrolimus and Mycophenolic Acid Have a Limited Inhibitory Effect on Monocyte Signaling Pathway Phosphorylation, Function and Differentiation.

    N. Kannegieter,1 D. Hesselink,1 M. Dieterich,1 R. Kraaijeveld,1 A. Rowshani,1 P. Leenen,2 C. Baan.1

    1Internal Medicine, Erasmus MC, Rotterdam, Netherlands; 2Immunology, Erasmus MC, Rotterdam, Netherlands

    Introduction Monocytes and macrophages play key roles in cellular and humoral rejection after solid organ transplantation, but little is known about the effects of the…
  • 2017 American Transplant Congress

    A Lower Mean Exposure to Tacrolimus, Not Intra-Patient Variability Is Associated with Chronic Active Antibody Mediated Rejection.

    K. Sablik,1 M. Clahsen–van Groningen,2 T. Van Gelder,1 M. Betjes.1

    1Nephrology and Transplantation, Erasmus MC, Rotterdam, Netherlands; 2Pathology, Erasmus MC, Rotterdam, Netherlands

    Introduction. Chronic active antibody mediated rejection (caABMR) is one of the major causes of long-term kidney graft loss. It is hypothesized that frequent underexposure and…
  • 2017 American Transplant Congress

    Non-Donor-Specific Anti-HLA Antibodies Have an Adverse Impact in Kidney Graft Outcomes.

    J. Malheiro,1 S. Tafulo,2 L. Dias,1 L. Martins,1 I. Beirão,1 A. Castro-Henriques.1

    1CHP, Porto, Portugal; 2IPST, Porto, Portugal

    Few studies have studied the impact of non-donor-specific antibodies (NDSA) in kidney transplantation (KT), with most showing no impact of these antibodies. As antibody-mediated graft…
  • 2017 American Transplant Congress

    Contribution of Donor versus Recipient T Cells in Face Transplant Rejection.

    T. Win,1 N. Murakami,2 I. Avraham-Davidi,1 J. Teague,1 E. Lowry,1 R. Lopdrup,1 E. Bueno,1 A. Chandraker,1 L. Riella,1 B. Pomahac,1 R. Clark.1

    1Brigham and Women's Hospital, Boston; 2Broad Institute of MIT and Harvard, Cambridge

    BackgroundSkin-containing transplants such as facial allografts contain resident populations of donor T cells. Although the role of T cells in acute rejection is well established,…
  • 2017 American Transplant Congress

    Very Long Term Graft Survival. Forecasts Factors.

    S. Jimenez Alvaro, R. Marcen Letosa, A. Fernandez Rodriguez, S. Elias Treviño, C. Galeano Alvarez, F. Liaño Garcia.

    Nephrology, Hospital Ramon y Cajal, Madrid, Spain

    Introduction: Kidney transplantation is the best treatment for end-stage renal failure. Between 2 and 5% of transplanted grafts are lost each year and only a…
  • 2017 American Transplant Congress

    The Immunophenotype of Peritubular Capillaritis in Renal Transplant Biopsies.

    T. Chen,1 L. Rasch,1 T. Al Johani,2 H. McPhail,1 M. Willicombe,3 A. McLean,3 J. Galliford,3 T. Cook,1 C. Roufosse.1

    1Centre for Complement and Inflammation Research, Imperial College, London, United Kingdom; 2Cellular Pathology, King Saud University, Riyadh, Saudi Arabia; 3Dept Renal Medicine, Imperial College Healthcare NHS Trust, London, United Kingdom

    Background: Peritubular capillaritis (ptc) is a feature of acute antibody-mediated rejection (ABMR) in the renal allograft. However, it is not an specific feature for ABMR…
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