2017 American Transplant Congress
CXCL13 as a New Systemic Biomarker for B-Cell Involvement in Acute Kidney Allograft Rejection.
The majority of kidney allograft rejections are T cell mediated (TCMR). However, it has been shown that in the presence of B-cell clusters the course…2017 American Transplant Congress
Persistence/Progression of Early Banff Borderline Changes (BBC) Is Associated with Chronic Renal Allograft Damage and Can Be Predicted by B Cell Cytokine Profile.
The clinical significance of early histological BBC in kidney transplant recipients (KTR) is unclear. It is also unknown if biomarkers predict progression to acute rejection…2017 American Transplant Congress
Impact of Antihypertensive (AHT) Choice and Advagraf® Dose on Immunologic Events in Renal Allografts 24 Months Post-Transplantation (Tx).
Renal allograft inflammation may be modulated by ACEi- or ARB-type AHTs (renin-angiotensin system (RAS)-targeting drugs that may inhibit calcineurin) or by optimizing tacrolimus (TAC) exposure.…2017 American Transplant Congress
Tacrolimus Trough Concentration Variability and Disparities in African American Kidney Transplantation.
Low tacrolimus (FK) trough concentrations have been associated with higher risk of acute rejection, particularly within African-American (AA) kidney transplant recipients; less is known about…2017 American Transplant Congress
Differential Expression of Long Noncoding RNAs During Cardiac Allograft Rejection.
While transplant rejection is the major restriction in successful long lasting graft survival, induction of sustainable immune tolerance against transplant is one of the major…2017 American Transplant Congress
Neutropenia in Kidney Transplantation: A Hidden Threat to Graft Survival.
Medstar Georgetown Transplant Institute, Washington, DC
IntroductionNeutropenia is a common complication after kidney transplantation resulting in a reduction of immunosuppression and the use of granulocyte colony-stimulating factors (G-CSF) which can increase…2017 American Transplant Congress
Not All Cellular Rejections Are the Same: Differences in Early and Late Hepatic Allograft Rejection.
While acute cellular rejection (ACR) after liver transplantation (LT) is not thought to cause long-term graft injury and inferior outcomes, this notion has been challenged…2017 American Transplant Congress
Development of De Novo Donor Specific Antibodies (dnDSAs) Not the Presence of Pre-Transplant Donor Specific Antibodies (Pre-DSAs) Increase Rejection Risk in Crossmatch Negative Kidney Transplant Recipients.
Mayo Clinic Arizona, Phoenix, AZ
Aim: Study the impact of Pre-DSAs on allograft outcomes in crossmatch negative kidney transplant recipients.Methods: Single center retrospective analysis of characteristics and outcomes of kidney…2017 American Transplant Congress
Which Is More Nephrotoxic to Kidney Transplants: BK Nephropathy or Rejection?
University of Wisconsin, Madison
The relative nephrotoxicity of BK nephropathy (BKN) vs acute rejection is unknown. This is an important question, since clinicians often must choose between reducing immunosuppression…2017 American Transplant Congress
Molecular Classifier of Antibody-Mediated Rejection Is a Better Predictor of Histologic Rejection Than a Corresponding Transcript Set and Is Further Improved When Combined with Classifiers of Rejection Syndromes.
University of Alberta, Edmonton, AB, Canada
Molecular and histologic changes in graft rejection are not completely specific, often being induced by injuries and other diseases. We examined various methods for using…
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