2017 American Transplant Congress
Designing a Novel Selective Immunoproteasome Inhibitor Reveals a Critical Role of the IP and STAT5 Pathway in Regulating T Cell Exhaustion and Promoting Long Term Heart Allograft Acceptance.
Constitutive proteasomes (c-20S) are ubiquitously expressed cellular proteases that degrade polyubiquitinated proteins and regulate cell functions. Immunoproteasomes (IP or i-20S) are primarily expressed in immune…2017 American Transplant Congress
The Molecular Phenotypes of Rejection in Kidney Transplant Biopsies.
University of Alberta, Edmonton, AB, Canada
In a microarray analysis of 1208 kidney transplant indication biopsies, each biopsy was assigned molecular scores for seven phenotypes related to various aspects of TCMR,…2017 American Transplant Congress
C5b-9 Deposition in Glomerular Capillaries Is Responsible for Poor Allograft Survival in Antibody-Mediated Rejection.
1University Hospital, Montpellier, France; 2Cancer Research Institute, Montpellier, France
Introduction: C4d (scare of C4 cleavage) deposition in peritubular capillaries (PTC), a marker of complement activation, is associated with antibody-mediated rejection (AMR) in kidney transplantation.…2017 American Transplant Congress
Activated Th1 and Th17 cTFH Phenotype Correlates with DSA Production in Kidney Transplant Recipients.
University of Pittsburgh, Starzl Transplantation Institute, Pittsburgh
Donor-specific anti-HLA antibodies (DSA) represent an important biomarker for acute rejection and are a major cause of long-term graft failure after kidney transplantation (KTx). The…2017 American Transplant Congress
MicroRNAs Differentiate Between Antibody and T-Cell Mediated Renal Allograft Rejection.
Purpose: MicroRNAs are important immune regulators of gene and protein expression. Both circulating and intragraft expression of microRNAs have been related to renal allograft rejection.…2017 American Transplant Congress
Immune Activation and Rejection Risk in HIV-Positive Kidney Transplantation.
Division of Transplantation, University of California, San Francisco, San Francisco, CA
Purpose: HIV+ kidney transplant recipients experience higher rates of rejection episodes when compared to HIV- recipients. We hypothesize that this early, aggressive rejection is associated…2017 American Transplant Congress
C-C Chemokine Receptor 5 Polymorphisms and Risk of Antibody-Mediated Rejection in Renal Transplantation.
Antibody-mediated rejection (AMR) is the leading cause of graft failure after kidney transplantation. C-C Chemokine receptor 5 (CCR5) plays an important role in immune cell…2017 American Transplant Congress
Early Rejection in the Elderly: Is It Predictable?
University of Maryland Medical Center, Baltimore, MD
Introduction: Optimal induction for elderly kidney transplant recipients (KTR) remains unclear. Older age may be associated with decreased immunogenicity; however, clinical heterogeneity of the elderly…2017 American Transplant Congress
Time to First Therapeutic Tacrolimus Level: What Impact Does It Have After Heart Transplantation?
University of Pittsburgh Medical Center, Pittsburgh, PA
Purpose: Appropriate time to therapeutic immunosuppression levels is not well defined. The purpose of this study is to investigate outcomes related to time to therapeutic…2017 American Transplant Congress
Soluble Fibrinogen-Like Protein 2 Regulates Differentiation and Enhances Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Allograft Immunity.
Urology, Zhongshan Hospital, Fudan University, Shanghai, China
Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an important…
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