Articles tagged "Rejection"

2017 American Transplant Congress
Tocilizmab (Anti-IL-6R) Treatment (TCZ-Rx) Reduced Total IgG Levels Including Anti-HLA IgG: Analysis of IgG Subclasses (IgG1-IgG4) and Anti-HLA IgG Subclasses Show Similar Reductions in All Subclasses from Patients with DSA+ Chronic Antibody-Mediated Rejection (CABMR).
B.-H. Shin,¹ M. Everly,² J. Choi,¹ S. Ge,¹ A. Petrosyan,¹ A. Vo,¹ S. Jordan,¹ M. Toyoda.¹
¹Transplant Immunology Laboratory and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Terasaki Foundation Laboratory, Los Angeles
Background: DSA+ CABMR constitutes the major cause for renal allograft loss in the U.S. Currently there are no approved therapies. We have reported TCZ use…
2017 American Transplant Congress
Pre-Operative Desensitization for Live Donor Liver Transplantation with Strong Donor-Specific Antibodies.
M. Fujiki,¹ K. Hashimoto,¹ A. Zhang,² F. Aucejo,¹ C. Quintini,¹ T. Diago,¹ B. Eghtesad,¹ C. Miller.¹
¹General Surgery, Cleveland Clinic, Cleveland, OH; ²Allogen Laboratories, Cleveland Clinic, Cleveland, OH
Background: Presence of strong donor-specific antibodies (DSA) (MFI>4000) likely results in uncomplicated short-term outcome in whole liver transplants due to absorption of DSA by the…
2017 American Transplant Congress
A Novel Role for MyD88 Signaling Downstream from Toll-Like Receptors in B Cells Responding to Blood Group Antigens.
H. Sakai, Y. Tanaka, H. Ohdan.
Hiroshima University, Hiroshima, Japan
[Introduction]Although there is some empirical evidence that severe infectious complications provoke refractory AMR following ABO-incompatible transplantations (ABOi-Tx), its mechanism remains unclear. Here, we investigated a…
2017 American Transplant Congress
Identification of Plasma Protein Biomarkers of Acute Renal Allograft Rejection.
M. Rossetti,¹ C. Fitzpatrick,¹ N. Harre,¹ Y. Zheng,¹ N. Mercer,² G. Sunga,¹ D. Gjertson,¹ E. Reed.¹
¹Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA; ²Department of Biostatistics, University of California Los Angeles, Los Angeles, CA
Background & Aim: Upon presentation of clinical symptoms, renal transplant recipients routinely undergo needle core biopsy to diagnose acute graft rejection. This procedure is invasive…
2017 American Transplant Congress
A Prospective Observational Study to Evaluate Use of a Panel of Reactive T Cell (PRT) Assay as a Pre-Transplant Marker of Rejection in Kidney Transplant Recipients.
D. Brennan,¹ L. Kayler,² D. Wojciechowski,³ A. Limaye,⁴ A. Gaber,⁵ I. Durrant.⁶
¹Washington University, St. Louis, MO; ²Erie County Medical Center, Buffalo, NY; ³Massachusetts General Hospital, Boston, MA; ⁴Washington University, Seattle, WA; ⁵Houston Methodist, Houston, TX; ⁶Oxford Immunotec, Oxfordshire, United Kingdom
Background:To assess risk of T cell mediated acute rejection a recently developed assay uses a panel of reactive T cell lines (PRT) to measure recipient…
2017 American Transplant Congress
Type of Surgical Procedures and Clinical Significance of Calcineurin Inhibitor Temporary Discontinuation Regarding LT Recipients Undergoing Major Elective Surgery.
C. Cho, J. Lee, K. Kim, S. Kim, J. Lee, K. Lee, J.-M. Kim, G.-S. Choi, C. Kwon, J.-W. Joh.
Surgery, Samsung Medical Center, Seoul, Republic of Korea
Background As patients increasingly have undergone live transplantation (LT) and improved expected survival rate, there is a growing population of LT recipient undergoing elective surgery…
2017 American Transplant Congress
Long-Term Liver and Kidney Survival Following Combined Liver-Kidney Transplantation, with or without Preformed Donor-Specific Antibodies.
A. Del Bello,¹ O. Bestard,² J. Visentin,³ N. Congy-Jolivet,¹ L. Couzi,³ M. Neau-Cransac,³ F. Jambon,³ N. Kamar.¹
¹Nephrology and Organ Transplant Department, CHU Toulouse, Toulouse, France; ²Nephrology and Kidney Transplant Department, Bellvitge University Hospital, Barcelona, Spain; ³Nephrology and Kidney Transplant Department, CHU Bordeaux, Bordeaux, France
Introduction: Successful kidney transplantation despite a positive crossmatch is well known after combined liver-kidney transplantation (CLKT). However, recently, concerns regarding the impact of preformed anti-HLA…
2017 American Transplant Congress
Host-Derived, Intragraft Dendritic Cells Are Extensively Cross-Dressed by Donor MHC.
A. Hughes, H. Dai, A. Williams, M. Oberbarnscheidt, A. Morelli, F. Lakkis.
Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsbugh, PA
Host dendritic cells (DC) are the primary driver of transplant rejection in secondary lymphoid tissues where they activate alloreactive T cells. Directly alloreactive T cells…
2017 American Transplant Congress
Repeat Biopsies After the Diagnosis of BK Virus Associated Nephropathy: Importance of Integrating Clinical and Pathological Findings.
C. Drachenberg,¹ J. Papadimitriou,¹ R. Ugarte,² M. Mavanur,² B. Thomas,² C. Cangro,² N. Costa,² M. Weir,² A. Haririan.²
¹Pathology, University of Maryland School of Medicine, Baltimore, MD; ²Medicine, University of Maryland School of Medicine, Baltimore, MD
Early diagnosis of PV nephropathy(PyVAN) leads to overall improvements in the short term but sclerosing sequelae and risk for rejection (mainly antibody mediated) contribute to…
2017 American Transplant Congress
Donor-Specific B Cell Responses: Predicting the Future of Kidney Transplants.
M. Cascalho,¹ E. Farkash,² L. Adam,¹ M. Samaniego,³ J. Platt.
¹Surgery, University of Michigan, Ann Arbor; ²Pathology, University of Michigan, Ann Arbor; ³Internal Medicine, University of Michigan, Ann Arbor
Allogeneic cell and tissue transplants nearly always evoke B cell responses ascertainable by detecting donor-specific antibodies (DSA) in the circulation of the recipient. DSA are…