Articles tagged "Rejection"

2017 American Transplant Congress
Regulatory T Cells Inhibit Plasmablast Formation and IgG Production by Tempering T Follicular Helper Cell Function.
P. Fadakar, C. Macedo, M. Yamada, K. Hadi, D. Metes.
Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA
Background: Donor-specific antibodies (DSA) are an important biomarker for acute rejection, transplant glomerulopathy and late allograft failure in kidney transplantation. Few studies have characterized the…
2017 American Transplant Congress
Quantitative Gene Expression Analysis of CRM-Panel Genes Using FFPE Kidney Tissues for Transplant Injuries.
T. Sigdel, M. Nguyen, D. Dobi, S.-C. Hsieh, J. Liberto, F. Vincenti, M. Sarwal, Z. Laszik.
University of California San Francisco, San Francisco
Background: A common immune response module (CRM) of 11 genes was identified to define acute rejection (AR) through meta-analyses of 1030 different engrafted tissues including…
2017 American Transplant Congress
Mitochondrial Permeability Can Regulate Endothelial Cell Necroptosis and Promote Cardiac Allograft Rejection.
I. Gan,^1,2 J. Jiang,¹ D. Lian,¹ A. Jevnikar,^1,3 Z.-X. Zhang.^1,2
¹Matthew Mailing Centre for Translational Transplant Studies, Western University, London, ON, Canada; ²Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada; ³Department of Medicine, Western University, London, ON, Canada
Background: Transplant injury is invariably associated with programmed cell death (PCD) resulting in organ rejection. Many forms of PCD have been described including apoptosis, pyroptosis,…
2017 American Transplant Congress
Tocilizmab (Anti-IL-6R) Treatment (TCZ-Rx) Reduced Total IgG Levels Including Anti-HLA IgG: Analysis of IgG Subclasses (IgG1-IgG4) and Anti-HLA IgG Subclasses Show Similar Reductions in All Subclasses from Patients with DSA+ Chronic Antibody-Mediated Rejection (CABMR).
B.-H. Shin,¹ M. Everly,² J. Choi,¹ S. Ge,¹ A. Petrosyan,¹ A. Vo,¹ S. Jordan,¹ M. Toyoda.¹
¹Transplant Immunology Laboratory and Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ²Terasaki Foundation Laboratory, Los Angeles
Background: DSA+ CABMR constitutes the major cause for renal allograft loss in the U.S. Currently there are no approved therapies. We have reported TCZ use…
2017 American Transplant Congress
Pre-Operative Desensitization for Live Donor Liver Transplantation with Strong Donor-Specific Antibodies.
M. Fujiki,¹ K. Hashimoto,¹ A. Zhang,² F. Aucejo,¹ C. Quintini,¹ T. Diago,¹ B. Eghtesad,¹ C. Miller.¹
¹General Surgery, Cleveland Clinic, Cleveland, OH; ²Allogen Laboratories, Cleveland Clinic, Cleveland, OH
Background: Presence of strong donor-specific antibodies (DSA) (MFI>4000) likely results in uncomplicated short-term outcome in whole liver transplants due to absorption of DSA by the…
2017 American Transplant Congress
A Novel Role for MyD88 Signaling Downstream from Toll-Like Receptors in B Cells Responding to Blood Group Antigens.
H. Sakai, Y. Tanaka, H. Ohdan.
Hiroshima University, Hiroshima, Japan
[Introduction]Although there is some empirical evidence that severe infectious complications provoke refractory AMR following ABO-incompatible transplantations (ABOi-Tx), its mechanism remains unclear. Here, we investigated a…
2017 American Transplant Congress
Activation of Inflammation Amplifier in Kidney Graft and Urinary Biomarker for Chronic Rejection.
H. Higuchi,^1,2 D. Iwami,¹ K. Hotta,¹ N. Shinohara,¹ M. Murakami.²
¹Hokkaido University, Renal and Genitourinary Surgery, Sapporo, Hokkaido, Japan; ²Hokkaido University, Molecular Neuroimmunology, Institute of Genetic Medicine, Graduate School of Medicine, Sapporo, Hokkaido, Japan
[Introduction and Objective] Inflammation amplifier (IA), a local chemokine inducer in non-immune cells is induced by simultaneous activation of NFκB and STATs (IL-17, TNFα, and…
2017 American Transplant Congress
Practice Patterns in the Treatment and Monitoring of Acute Cell-Mediated Kidney Graft Rejection in Canada.
J. Leblanc,¹ P. Subrt,² M. Paré,³ D. Hartell,⁴ L. Sénécal,⁵ T. Blydt-Hansen,⁶ H. Cardinal.¹
¹Medicine, Centre Hospitalier de l'Universite de Montreal, Montreal, Canada; ²Child and Family Research Institute, Vancouver, Canada; ³University of Montreal, Montreal, Canada; ⁴Canadian National Transplant Research Program, Edmonton, Canada; ⁵Medicine, Hôpital Maisonneuve-Rosemont, Montreal, Canada; ⁶Pediatrics, BC Children Hospital, Vancouver, Canada
Aim: to gather clinicians' views and practice patterns on the diagnosis, treatment and monitoring of acute T-cell mediated rejection (TCMR) in Canada.Methods: As part of…
2017 American Transplant Congress
Treating Refractory Liver Allograft Rejection with Photopheresis.
I. Lopez Plaza,¹ A. Eisenbrey,¹ M. Raoufi,¹ A. Yoshida,² D. Moonka.²
¹Department of Pathology and Laboratory Medicine, Henry Ford Health System, Detroit, MI; ²Transplant Institute, Henry Ford Health System, Detroit, MI
DSAs with persistent high titer alloantibodies are associated with refractory antibody mediated rejection (AMR) and liver injury.METHODS: We present 4 liver transplant (LT) patients refractory…
2017 American Transplant Congress
Long-Term Liver and Kidney Survival Following Combined Liver-Kidney Transplantation, with or without Preformed Donor-Specific Antibodies.
A. Del Bello,¹ O. Bestard,² J. Visentin,³ N. Congy-Jolivet,¹ L. Couzi,³ M. Neau-Cransac,³ F. Jambon,³ N. Kamar.¹
¹Nephrology and Organ Transplant Department, CHU Toulouse, Toulouse, France; ²Nephrology and Kidney Transplant Department, Bellvitge University Hospital, Barcelona, Spain; ³Nephrology and Kidney Transplant Department, CHU Bordeaux, Bordeaux, France
Introduction: Successful kidney transplantation despite a positive crossmatch is well known after combined liver-kidney transplantation (CLKT). However, recently, concerns regarding the impact of preformed anti-HLA…