2017 American Transplant Congress
Islet Rejection in Autoimmune NOD Mouse Recipients: Implications for Stem Cell Therapies.
Several efforts are ongoing to use stem cell precursors to generate islet-like tissues suitable for transplantation in autoimmune Type 1 diabetic (T1D) recipients. During the…2017 American Transplant Congress
Single Nuclear Polymorphisms of Complement Component 4 and Component 5 in Renal Transplant Recipients with Antibody-Mediated Rejection.
Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Background: Antibody-mediated rejection (ABMR) is an important cause of allograft dysfunction in short-term and long-term period. The complement component 4 (C4) and component 5 (C5)…2017 American Transplant Congress
Tacrolimus and Mycophenolic Acid Have a Limited Inhibitory Effect on Monocyte Signaling Pathway Phosphorylation, Function and Differentiation.
Introduction Monocytes and macrophages play key roles in cellular and humoral rejection after solid organ transplantation, but little is known about the effects of the…2017 American Transplant Congress
A Lower Mean Exposure to Tacrolimus, Not Intra-Patient Variability Is Associated with Chronic Active Antibody Mediated Rejection.
Introduction. Chronic active antibody mediated rejection (caABMR) is one of the major causes of long-term kidney graft loss. It is hypothesized that frequent underexposure and…2017 American Transplant Congress
Non-Donor-Specific Anti-HLA Antibodies Have an Adverse Impact in Kidney Graft Outcomes.
1CHP, Porto, Portugal; 2IPST, Porto, Portugal
Few studies have studied the impact of non-donor-specific antibodies (NDSA) in kidney transplantation (KT), with most showing no impact of these antibodies. As antibody-mediated graft…2017 American Transplant Congress
Contribution of Donor versus Recipient T Cells in Face Transplant Rejection.
1Brigham and Women's Hospital, Boston; 2Broad Institute of MIT and Harvard, Cambridge
BackgroundSkin-containing transplants such as facial allografts contain resident populations of donor T cells. Although the role of T cells in acute rejection is well established,…2017 American Transplant Congress
Very Long Term Graft Survival. Forecasts Factors.
Nephrology, Hospital Ramon y Cajal, Madrid, Spain
Introduction: Kidney transplantation is the best treatment for end-stage renal failure. Between 2 and 5% of transplanted grafts are lost each year and only a…2017 American Transplant Congress
The Immunophenotype of Peritubular Capillaritis in Renal Transplant Biopsies.
Background: Peritubular capillaritis (ptc) is a feature of acute antibody-mediated rejection (ABMR) in the renal allograft. However, it is not an specific feature for ABMR…2017 American Transplant Congress
The Effect of Histological Isolated Endarteritis and Solid Endoarteritis Combined with CD20 Positive B Cell Infiltration Appeared in Acute Cellular Rejection on Kidney Allograft Survival.
BackgroundEndarteritis post renal transplantation is regarded as T-cell mediated acute rejection by Banff classification. Recently, results from DNA microarrays suggested that endovasculitis did not represent…2017 American Transplant Congress
Clinical and Histopathologic Features of Antibody Mediated Rejection (ABMR) in Highly Sensitized (HS) vs Non-Sensitized (NS) Pediatric Renal Transplant Recipients.
Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
Background: The presence of preformed donor-specific antibody (pDSA) in HS pts and development of de-novo DSA (dnDSA) in NS patients are risk factors for ABMR.…
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