2017 American Transplant Congress
Soluble Fibrinogen-Like Protein 2 Regulates Differentiation and Enhances Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Allograft Immunity.
Urology, Zhongshan Hospital, Fudan University, Shanghai, China
Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an important…2017 American Transplant Congress
Pro Inflammatory Transitional B (TrB) Cells Characterize Renal Allograft Recipients with DSA and T Cell Mediated Rejection (TCMR).
De novo DSA detected post-renal transplantation is associated with adverse outcomes. We have shown that de novo DSA is strongly associated with TCMR. In this…2017 American Transplant Congress
Acute Antibody-Mediated Rejection in Pediatric Liver Transplantation.
Donor-specific antibodies (DSA) and antibody mediated rejection (AMR) are associated with decreased graft survival in pediatric liver transplantation; however, the incidence of AMR is not…2017 American Transplant Congress
Clinical Significance of Alloantibodies in Hand Transplantation: Impact on Rejection and Functional Outcome.
Purpose: Although alloantibodies, and donor-specific antibodies (DSA) in particular, are well-known to negatively impact graft survival in human solid organ transplantation, little is known about…2017 American Transplant Congress
Designing a Novel Selective Immunoproteasome Inhibitor Reveals a Critical Role of the IP and STAT5 Pathway in Regulating T Cell Exhaustion and Promoting Long Term Heart Allograft Acceptance.
Constitutive proteasomes (c-20S) are ubiquitously expressed cellular proteases that degrade polyubiquitinated proteins and regulate cell functions. Immunoproteasomes (IP or i-20S) are primarily expressed in immune…2017 American Transplant Congress
The Molecular Phenotypes of Rejection in Kidney Transplant Biopsies.
University of Alberta, Edmonton, AB, Canada
In a microarray analysis of 1208 kidney transplant indication biopsies, each biopsy was assigned molecular scores for seven phenotypes related to various aspects of TCMR,…2017 American Transplant Congress
C5b-9 Deposition in Glomerular Capillaries Is Responsible for Poor Allograft Survival in Antibody-Mediated Rejection.
1University Hospital, Montpellier, France; 2Cancer Research Institute, Montpellier, France
Introduction: C4d (scare of C4 cleavage) deposition in peritubular capillaries (PTC), a marker of complement activation, is associated with antibody-mediated rejection (AMR) in kidney transplantation.…2017 American Transplant Congress
Activated Th1 and Th17 cTFH Phenotype Correlates with DSA Production in Kidney Transplant Recipients.
University of Pittsburgh, Starzl Transplantation Institute, Pittsburgh
Donor-specific anti-HLA antibodies (DSA) represent an important biomarker for acute rejection and are a major cause of long-term graft failure after kidney transplantation (KTx). The…2017 American Transplant Congress
MicroRNAs Differentiate Between Antibody and T-Cell Mediated Renal Allograft Rejection.
Purpose: MicroRNAs are important immune regulators of gene and protein expression. Both circulating and intragraft expression of microRNAs have been related to renal allograft rejection.…2017 American Transplant Congress
Immune Activation and Rejection Risk in HIV-Positive Kidney Transplantation.
Division of Transplantation, University of California, San Francisco, San Francisco, CA
Purpose: HIV+ kidney transplant recipients experience higher rates of rejection episodes when compared to HIV- recipients. We hypothesize that this early, aggressive rejection is associated…
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