Articles tagged "Rejection"

2017 American Transplant Congress
Dual Treatment of Suboptimal Doses of CsA and MSC Infusion Fully Prevents Acute Rejection in an Allogenic Model of Renal Transplantation.
L. de Ramon,¹ A. Merino,¹ E. Ripoll,¹ N. Bolaños,¹ M. Gomà,³ J. Cruzado,^1,2 J. Grinyó,^1,2 J. Torras.^1,2
¹Experimental Nephrology, IDIBELL-UB, Hospitalet Llobregat, Barcelona, Spain; ²Nephrology, Hospital Universitari de Bellvitge, Hospitalet Llobregat, Barcelona, Spain; ³Pathology, Hospital Universitari de Bellvitge, Hopitalet Llobregat, Barcelona, Spain
The immunomodulatory characteristics of mesenchymal stem cells (MSCs) may lead to multifaceted strategies in rejection of organ transplantation. This study was designed to investigate the…
2017 American Transplant Congress
Is Thymic Function Determining Rejection Onset in Heart Transplantation?
A. Sannier,^1,2 R. Dorent,^1,3 M. Le Borgne,¹ N. Stroumza,¹ J. Senemaud,¹ L. Louedec,¹ F. Andreata,¹ A. Gaston,¹ C. Deschildre,¹ P. Nataf,^1,3 A. Couvelard,² G. Caligiuri,¹ A. Nicoletti.¹
¹Inserm U1148, Diderot University, Paris, France; ²Pathology Department, Bichat Hospital, Paris, France; ³Cardiac Surgery Department, Bichat Hospital, Paris, France
The thymus is the primary site of T cell development, involuting into fatty tissue in adults. Thymic function persists in the adulthood and may be…
2017 American Transplant Congress
Retrospective Analysis of Kidney Transplant Recipients with Antibody-Mediated Rejection.
G. Piñeiro,¹ E. Desousa,¹ J. Villarreal,¹ M. Lozano,² J. Cid,² M. Sole,³ F. Oppenheimer,¹ F. Diekmann.¹
¹Nephrology and Renal Transplant, Hospital Clinic de Barcelona, Barcelona, Spain; ²Apheresis Unit, Department of Hemotherapy and Hemostasis, Hospital Clinic de Barcelona, Barcelona, Spain; ³Pathology, Hospital Clinic de Barcelona, Barcelona, Spain
Acute antibody mediated rejection (AMR) is a major cause of allograft loss.We retrospectively reviewed all kidney allograft recipients between 2002 and March 2016. Investigated the…
2017 American Transplant Congress
De Novo Malignancy Occurrence After Kidney Transplantation in HLA-Sensitized Patients Treated with B-Cell Targeting Therapy.
L. Couzi,^1,2,3 P. Davis,¹ J. Visentin,^1,2,3 B. Taton,¹ G. Guidicelli,¹ H. Kaminski,^1,2,3 P. Merville,^1,2,3 T. Bachelet.⁴
¹CHU de Bordeaux, Bordeaux, France; ²Université de Bordeaux, Bordeaux, France; ³UMR CNRS 5164 Immunoconcept, Bordeaux, France; ⁴Clinique Saint-Augustin-CTMR, Bordeaux, France
Management of high risk transplantations in patients with preformed DSA still remains a dilemma. Many groups propose to increase the immunosuppression in these patients by…
2017 American Transplant Congress
Immunosuppressive Therapy and Acute Rejection in Combined Heart and Kidney Transplantation.
M. Gallo, J. Trivedi, D. Abramov, R. Vijayakrishnan, M. Slaughter.
University of Louisville, Louisville
Background. This study evaluated the management of immunosuppressive therapy and the incidence of acute heart rejection within 1 year from concomitant heart-kidney transplantation (cHTKx) compared…
2017 American Transplant Congress
Which Tr1 Is Better for Transplant Tolerance Induction: Comparing the Tr1 Generated by IL-27 or TGF-βplus IL-27.
G. Gu, H. Hang, Q. Xia.
Department of Hepatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
IL-10 producing T cells (Tr1) are important for the transplant tolerance induction. However, Tr1 can be induced in two methods: IL-27 or TGF-βplus IL-27. We…
2017 American Transplant Congress
Steroid Free Maintenance Immunosupression in Kidney Transplantation: Indiana University Experience.
S. Hussain, T. Taber, A. Sharfuddin, M. Yaqub, W. Goggins, D. Mishler, O. Adebiyi.
Renal Transplant, Indiana University School of Medicine, Indianapolis, IN
Background: Steroid based maintenance Immunosuppression (IS) regimen is the standard protocol for many kidney transplant(tx) centers. However, concerns for chronic steroid impact on patients remains…
2017 American Transplant Congress
Acute Antibody-Mediated Rejection in Pediatric Liver Transplantation.
C. Eriksen,¹ M. Zimmerman,¹ J. Kim,¹ S. Lerret,² G. Telega,² B. Vitola,² J. Schiller,³ J. Hong.¹
¹Dept. of Surgery, Division of Transplant, Medical College of Wisconsin, Milwaukee; ²Dept of Pediatrics, Division of Gastroenterology, Medical College of Wisconsin, Milwaukee; ³Director, Histocompatibility Laboratory, Medical College of Wisconsin, Milwaukee
Donor-specific antibodies (DSA) and antibody mediated rejection (AMR) are associated with decreased graft survival in pediatric liver transplantation; however, the incidence of AMR is not…
2017 American Transplant Congress
Clinical Significance of Alloantibodies in Hand Transplantation: Impact on Rejection and Functional Outcome.
E. Berglund,¹ M. Andersen Ljungdahl,¹ D. Bogdanovic,¹ D. Berglund,³ J. Wadström,¹ A. Weissenbacher,² P. Petruzzo,⁴ S. Schneeberger.²
¹Karolinsk Institutet, Dpt of Clinical Science, Intervention, and Technology, Stockholm, Sweden; ²Innsbruck Medical University, Center for Operative Medicine, Innsbruck, Austria; ³Uppsala University, Dpt of Immunology, Genetics and Pathology, Section of Clinical Immunology, Uppsala, Sweden; ⁴Edouard Herriot Hospital, Dpt of Transplantation, Lyon, France
Purpose: Although alloantibodies, and donor-specific antibodies (DSA) in particular, are well-known to negatively impact graft survival in human solid organ transplantation, little is known about…
2017 American Transplant Congress
Designing a Novel Selective Immunoproteasome Inhibitor Reveals a Critical Role of the IP and STAT5 Pathway in Regulating T Cell Exhaustion and Promoting Long Term Heart Allograft Acceptance.
S. Routray, E. Karreci, M. Uehara, J. Assaker, A. Mihali, S. Eskandari, L. Riella, R. Abdi, Y. Kawano, C. Nathan, G. Lin, J. Azzi.
Transplant Research Center, Harvard Medical School, Boston, MA; Microbiology and Immunology, Weill Cornell Medicine, New York, NY
Constitutive proteasomes (c-20S) are ubiquitously expressed cellular proteases that degrade polyubiquitinated proteins and regulate cell functions. Immunoproteasomes (IP or i-20S) are primarily expressed in immune…