Articles tagged "Rejection"

2017 American Transplant Congress
Do Perioperative Blood Transfusions Influence Kidney Transplant Outcomes in the Modern Era?
J. Lineen, J. Trac, Y. Li, O. Famure, J. Kim.
Multi-Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, ON, Canada
Background: Blood transfusions are a well-established risk factor for human leukocyte antigen sensitization in kidney transplant candidates. To date, relatively few studies have explored the…
2017 American Transplant Congress
Rejection of Human Kidney Allografts According to BANFF Classification Is Associated with a Chemokine-Enriched Protein Microenvironment in Biopsy Tssue.
C. Falk,¹ K. Daemen,¹ J. Keil,¹ F. Lehner,² H. Haller,³ J. Schmitz,⁴ J.-H. Bräsen,⁴ C. Blume.⁵
¹Institute of Transplant Immunology, IFB-Tx, Hannover Medical School, Hannover, Germany; ²Department of Abdominal, Visceral and Transplantation Surgery, Hannover Medical School, Hannover, Germany; ³Department of Nephrology and Hypertension, Hannover Medical School, Hannover, Germany; ⁴Institute of Pathology, Hannover Medical School, Hannover, Germany; ⁵Institute for Technical Chemistry, Leibniz University, Hannover, Germany
Background: Expression profiling efforts of biopsy tissue after kidney transplantation indicate that rejection can be defined by distinct signatures. Based on pathological evaluation (BANFF) as…
2017 American Transplant Congress
Prediction of Renal Allograft Acute Rejection Using a Novel Non-Invasive Model Based on Acoustic Radiation Force Impulse.
C. Yang,¹ Y. Jin,² S. Wu,³ T. Zhu,¹ W. He.²
¹Urology, Zhongshan Hospital, Fudan University, Shanghai, China; ²Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, China; ³Gastroenterology and Hepatology, Zhongshan Hospital, Fudan University, Shanghai, China
Point shear wave elastography (p-SWE) based on acoustic radiation force impulse (ARFI) is a novel technology to quantify tissue stiffness by measuring shear wave speed…
2017 American Transplant Congress
Adjunctive Thymoglobulin with Proteasome Inhibitor Based Treatment of Late Mixed Acute Rejection.
A. Lichvar,¹ A. Leino,¹ S. Tremblay,¹ A. Shields,² F. Paterno,¹ A. Govil,¹ M. Anand,¹ T. Diwan,¹ J. Kremer,² R. Alloway,¹ E. Woodle.¹
¹University of Cincinnati, Cincinnati; ²The Christ Hospital, Cincinnati
Proteasome inhibitor (PI) containing regimens treat mixed acute rejection (MAR) at least in part due to elimination of donor specific antibody (DSA) and via effects…
2017 American Transplant Congress
mTOR Inhibition Diminishes Peripheral Blood CD8⁺CD28^–CD38^hi Effector/Memory T Cells and Facilitates Resolution of Belatacept-Refractory Kidney Rejection.
C. Castro-Rojas,¹ A. Godarova,¹ A. Leino,² R. Alloway,² M. Jordan,³ E. Woodle,² D. Hildeman.¹
¹Division of Immunobiology, Cincinnati Children's Hospital, University of Cincinnati College of Medicine, Cincinnati, OH; ²Division of Transplantation, University of Cincinnati College of Medicine, Cincinnati, OH; ³Division of Bone Marrow Transplant and Immune Deficiency, Cincinnati Children's Research Foundation, Cincinnati, OH
Belatacept, a CD28-CD80/86 blocker, was approved by the FDA to provide immunosuppression without nephrotoxicity or cardiovascular and metabolic adverse effects. As part of our multi-center…
2017 American Transplant Congress
Organs with Extended Cold Ischemia Time May Offer Aged Kidney Transplant Recipients New Options in an Expanded Donor Pool.
M. Postalcioglu,¹ B. Byun,¹ A. Kaze,² A. Siedlecki,¹ E. Milford,² R. Abdi.¹
¹Transplantation Research Center, Brigham and Women's Hospital, Boston, MA; ²Renal Division, Brigham and Women's Hospital, Boston, MA
Using data from the largest cohort of renal transplants, the aim of this study was to examine the effects of cold ischemia times (CIT) on…
2017 American Transplant Congress
Expression of T-Cell Mediated Rejection (TCMR) Associated Genes in Native and Renal Allograft Renal Biopsies with Inflamed Scars (i-IFTA).
Z. Lyu,¹ L. Pang,¹ G. Zeng,² Y. Huang,² P. Randhawa.²
¹Pathology & Nephrology, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China; ²Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA
The presence of i-IFTA in allograft kidney biopsies is a bad prognostic parameter. However, despite the presence of T-cell infiltrates in these lesions there is…
2017 American Transplant Congress
The Degree of NK Cell Activation Determines the Ability of Donor-Specific Antibodies to Mediate Acute vs. Chronic Rejection of Kidney Allografts.
T. Yagisawa,^1,2 T. Tanaka,¹ N. Dvorina,¹ A. Valujskikh,¹ W. Baldwin 3rd,¹ R. Fairchild.¹
¹Immunology and Glickman Urological Institute, Cleveland Clinic, Cleveland, OH; ²Urology, Tokyo Women's Medical University, Tokyo, Japan
While the incidence of antibody-mediated kidney graft rejection has increased, the key cellular and molecular participants underlying this graft injury remain unclear. We have previously…
2017 American Transplant Congress
Islet Rejection in Autoimmune NOD Mouse Recipients: Implications for Stem Cell Therapies.
R. Gill,¹ M. Coulombe,¹ T. Kupfer,¹ K. Beard,¹ A. Burrack.²
¹Surgery and Immunology, University of Colorado Denver, Aurora, CO; ²University of Minnesota, Minneapolis, MN
Several efforts are ongoing to use stem cell precursors to generate islet-like tissues suitable for transplantation in autoimmune Type 1 diabetic (T1D) recipients. During the…
2017 American Transplant Congress
Single Nuclear Polymorphisms of Complement Component 4 and Component 5 in Renal Transplant Recipients with Antibody-Mediated Rejection.
Z. Wang, Z. Han, J. Tao, R. Tan, M. Gu.
Urology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Background: Antibody-mediated rejection (ABMR) is an important cause of allograft dysfunction in short-term and long-term period. The complement component 4 (C4) and component 5 (C5)…