ATC Abstracts

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Articles tagged "Rejection"

  • 2017 American Transplant Congress

    Identification of Antibody-Mediated Rejection After Kidney Transplantation by Specific MicroRNAs.

    M. Matz,1 F. Heinrich,2 P. Durek,2 C. Lorkowski,1 K. Wu,3 N. Lachmann,4 K. Budde,1 M.-F. Mashreghi.2

    1University Medicine Charité-Nephrology, Berlin, Germany; 2German Rheumatism Research Centre DRFZ, Berlin, Germany; 3University Medicine Charité-Pathology, Berlin, Germany; 4University Medicine Charité-Transfusion Medicine, Berlin, Germany

    Antibody-mediated rejection (ABMR) is the major cause for allograft failure, since a curative therapy is lacking. There are also still challenges in ABMR diagnosis. The…
  • 2017 American Transplant Congress

    Intravoxel Incoherent Motion MRI Is an Effective Way to Monitor Acute Allograft Rejection in Rat Models.

    S. Zeng, X. Hu.

    Urology, Chao-Yang Hospital, Beijing, China

    Objectives: To combine the intravoxel incoherent motion MRI and blood oxygen level-dependent MRI for assessment of the renal allograft pathological process undergoing acute rejection and…
  • 2017 American Transplant Congress

    Donor Macrophage Depletion from CMV-Latently Infected Hearts Abrogates CMV-Accelerated Chronic Rejection.

    J. Burg,1 T. Andoh,2 N. Haese,2 I. Jones,2 S. Orloff,1 D. Streblow.2

    1Department of Surgery, OHSU, Portland, OR; 2VGTI, OHSU, Hillsboro, OR

    Purpose: Latent donor CMV infection has been shown to accelerate chronic rejection (CR) in a heterotopic rat heart transplant model. CMV latency is associated with…
  • 2017 American Transplant Congress

    Donor-Derived Cell-Free DNA Normal Range and Biological Variation Defined in a Reference Population.

    J. Bromberg,1 D. Brennan,2 E. Poggio,3 D. Hiller,4 R. Woodward,4 J. Yee,4 J. Sninsky,4 R. Bloom.5

    1University of Maryland, Baltimiore, MD; 2Washington University, St. Louis, MO; 3Cleveland Clinic, Cleveland, OH; 4CareDx, Brisbane, CA; 5University of Pennsylvania, Philadelphia, PA

    Purpose: Donor-derived cell-free DNA (dd-cfDNA) in the circulating blood of transplant recipients has shown promise as a non-invasive biomarker of acute rejection. This analysis was…
  • 2017 American Transplant Congress

    Ornithine Transcarbamylase Deficiency (OTC) in the Donor Liver, the Importance of Ascertaining the Cause of Death in the Brain Dead Donor.

    M. George,1 G. Thomas,1 A. Shun,1 M. Stormon.2

    1Paediatric Surgery and Transplant Surgery, Children's Hospital at Westmead, Sydney, NSW, Australia; 2Paediatric Gastroenterology, Children's Hospital at Westmead, Sydney, NSW, Australia

    The importance of ascertaining the cause of brain death in the donor is vital . We present a case of cadaveric liver donation (seg 2…
  • 2017 American Transplant Congress

    Subpopulations of Peripheral Blood Monocytes in Kidney Allograft Recipients.

    I. Striz,1 V. Svachova,1 A. Sekerkova,1 J. Slatinska,2 K. Kopecka,1 M. Fialova,1 O. Viklicky.2

    1Department of Clinical and Transplant Immunology, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic; 2Department of Nephrology, Transplant Centre, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic

    Human peripheral blood monocytes may be divided into different subsets based on the expression of membrane antigens. Our pilot data suggested that after the kidney…
  • 2017 American Transplant Congress

    Assessment of C4d Positive Biopsies with No Histological Evidence of Inflammation Using Nanostring nCounter Technology.

    K. Dominy,1 M. Willicombe,3 T. Al Johani,2 J. Galliford,3 A. McLean,3 T. Cook,3 C. Roufosse.3

    1Centre for Complement and Inflammation Research, Imperial College, London, United Kingdom; 2King Saud University, Riyadh, Saudi Arabia; 3Imperial College Healthcare NHS Trust, London, United Kingdom

    Deposition of C4d has been an established part of the Banff classification scheme for antibody mediated rejection (AbMR) since 2001. More recently, C4d negative AbMR…
  • 2017 American Transplant Congress

    The IL6/Th17 Pathway May Play Different Roles in Cell-Mediated and Antibody-Mediated Alloimmune Injury in Renal Allografts.

    D. Dobi,1 Q. Tang,2 S. Chandran,3 F. Vincenti,3 Z. Laszik.1

    1Department of Pathology, University of California, San Francisco, San Francisco, CA; 2Department of Surgery, Division of Transplant Surgery, University of California, San Francisco, San Francisco, CA; 3Department of Medicine, Division of Nephrology, University of California, San Francisco, San Francisco, CA

    Purpose. IL6 has been shown to contribute to shifting the balance between tolerogenic regulatory T cells and proinflammatory Th17 cells towards the latter. Our study…
  • 2017 American Transplant Congress

    Predictive Value of Renal Poly (ADP-Ribose) Polymerase (PARP) Expression Both in Inflammation and Interstitial Fibrosis Processes in Recipients with Antibody-Mediated Rejection.

    B. Ozdemir,1 F. Ozdemir,2 E. Baskin,2 M. Haberal.3

    1Pathology, Baskent University, Ankara, Turkey; 2Nephrology, Baskent University, Ankara, Turkey; 3Transplant Surgery, Baskent University, Ankara, Turkey

    The activation of PARP is well considered to play an augmenting role in inflammation. However, its role in the development of fibrosis is not well…
  • 2017 American Transplant Congress

    Tacrolimus Appears to Be a Protective Factor for De Novo DSA Formation in Non-Sensitized Kidney Transplant Patients.

    M. Marron-Wojewodzki,1 I. Szwarc,1 C. Rene,2 G. Mourad,1 M. Le Quintrec.1,3

    1Department of Nephrology, Dialysis and Transplantation, Hôpital Lapeyronie, Montpellier, France; 2Departement of Immunology, Hôpital Saint Eloi, Montpellier, France; 3Inserm U1183,, IRMB,Hôpital Saint Eloi, Montpellier, France

    Background.Development of de novo donor specific antibodies (dnDSA) concerns about 10% of patients within the first year following kidney transplantation and reach about 20% within…
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