Articles tagged "Rejection"

2017 American Transplant Congress
Effect of Preformed Donor-Specific Antibodies in Intestine/Multivisceral Transplantation.
M. Safwan,¹ M. Rizzari,¹ K. Collins,¹ A. Yoshida,¹ S. Skorupski,² O. Fagoaga,² M. Abouljoud,¹ S. Nagai.¹
¹Divison of Transplant and Hepatobiliary Surgery, Henry Ford Transplant Institute, Detroit, MI; ²Transplant Immunology, Henry Ford Hospital, Detroit, MI
Aim: To analyze the effect of preformed donor-specific antibodies (DSA) in intestine/multivisceral transplantation patients.Methods: Retrospective review of preformed and de novo DSAs of all intestine/multivisceral…
2017 American Transplant Congress
Identification of Antibody-Mediated Rejection After Kidney Transplantation by Specific MicroRNAs.
M. Matz,¹ F. Heinrich,² P. Durek,² C. Lorkowski,¹ K. Wu,³ N. Lachmann,⁴ K. Budde,¹ M.-F. Mashreghi.²
¹University Medicine Charité-Nephrology, Berlin, Germany; ²German Rheumatism Research Centre DRFZ, Berlin, Germany; ³University Medicine Charité-Pathology, Berlin, Germany; ⁴University Medicine Charité-Transfusion Medicine, Berlin, Germany
Antibody-mediated rejection (ABMR) is the major cause for allograft failure, since a curative therapy is lacking. There are also still challenges in ABMR diagnosis. The…
2017 American Transplant Congress
Intravoxel Incoherent Motion MRI Is an Effective Way to Monitor Acute Allograft Rejection in Rat Models.
S. Zeng, X. Hu.
Urology, Chao-Yang Hospital, Beijing, China
Objectives: To combine the intravoxel incoherent motion MRI and blood oxygen level-dependent MRI for assessment of the renal allograft pathological process undergoing acute rejection and…
2017 American Transplant Congress
Donor Macrophage Depletion from CMV-Latently Infected Hearts Abrogates CMV-Accelerated Chronic Rejection.
J. Burg,¹ T. Andoh,² N. Haese,² I. Jones,² S. Orloff,¹ D. Streblow.²
¹Department of Surgery, OHSU, Portland, OR; ²VGTI, OHSU, Hillsboro, OR
Purpose: Latent donor CMV infection has been shown to accelerate chronic rejection (CR) in a heterotopic rat heart transplant model. CMV latency is associated with…
2017 American Transplant Congress
Donor-Derived Cell-Free DNA Normal Range and Biological Variation Defined in a Reference Population.
J. Bromberg,¹ D. Brennan,² E. Poggio,³ D. Hiller,⁴ R. Woodward,⁴ J. Yee,⁴ J. Sninsky,⁴ R. Bloom.⁵
¹University of Maryland, Baltimiore, MD; ²Washington University, St. Louis, MO; ³Cleveland Clinic, Cleveland, OH; ⁴CareDx, Brisbane, CA; ⁵University of Pennsylvania, Philadelphia, PA
Purpose: Donor-derived cell-free DNA (dd-cfDNA) in the circulating blood of transplant recipients has shown promise as a non-invasive biomarker of acute rejection. This analysis was…
2017 American Transplant Congress
Ornithine Transcarbamylase Deficiency (OTC) in the Donor Liver, the Importance of Ascertaining the Cause of Death in the Brain Dead Donor.
M. George,¹ G. Thomas,¹ A. Shun,¹ M. Stormon.²
¹Paediatric Surgery and Transplant Surgery, Children's Hospital at Westmead, Sydney, NSW, Australia; ²Paediatric Gastroenterology, Children's Hospital at Westmead, Sydney, NSW, Australia
The importance of ascertaining the cause of brain death in the donor is vital . We present a case of cadaveric liver donation (seg 2…
2017 American Transplant Congress
Subpopulations of Peripheral Blood Monocytes in Kidney Allograft Recipients.
I. Striz,¹ V. Svachova,¹ A. Sekerkova,¹ J. Slatinska,² K. Kopecka,¹ M. Fialova,¹ O. Viklicky.²
¹Department of Clinical and Transplant Immunology, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic; ²Department of Nephrology, Transplant Centre, Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic
Human peripheral blood monocytes may be divided into different subsets based on the expression of membrane antigens. Our pilot data suggested that after the kidney…
2017 American Transplant Congress
Assessment of C4d Positive Biopsies with No Histological Evidence of Inflammation Using Nanostring nCounter Technology.
K. Dominy,¹ M. Willicombe,³ T. Al Johani,² J. Galliford,³ A. McLean,³ T. Cook,³ C. Roufosse.³
¹Centre for Complement and Inflammation Research, Imperial College, London, United Kingdom; ²King Saud University, Riyadh, Saudi Arabia; ³Imperial College Healthcare NHS Trust, London, United Kingdom
Deposition of C4d has been an established part of the Banff classification scheme for antibody mediated rejection (AbMR) since 2001. More recently, C4d negative AbMR…
2017 American Transplant Congress
The IL6/Th17 Pathway May Play Different Roles in Cell-Mediated and Antibody-Mediated Alloimmune Injury in Renal Allografts.
D. Dobi,¹ Q. Tang,² S. Chandran,³ F. Vincenti,³ Z. Laszik.¹
¹Department of Pathology, University of California, San Francisco, San Francisco, CA; ²Department of Surgery, Division of Transplant Surgery, University of California, San Francisco, San Francisco, CA; ³Department of Medicine, Division of Nephrology, University of California, San Francisco, San Francisco, CA
Purpose. IL6 has been shown to contribute to shifting the balance between tolerogenic regulatory T cells and proinflammatory Th17 cells towards the latter. Our study…
2017 American Transplant Congress
Predictive Value of Renal Poly (ADP-Ribose) Polymerase (PARP) Expression Both in Inflammation and Interstitial Fibrosis Processes in Recipients with Antibody-Mediated Rejection.
B. Ozdemir,¹ F. Ozdemir,² E. Baskin,² M. Haberal.³
¹Pathology, Baskent University, Ankara, Turkey; ²Nephrology, Baskent University, Ankara, Turkey; ³Transplant Surgery, Baskent University, Ankara, Turkey
The activation of PARP is well considered to play an augmenting role in inflammation. However, its role in the development of fibrosis is not well…