2017 American Transplant Congress
MicroRNAs Differentiate Between Antibody and T-Cell Mediated Renal Allograft Rejection.
Purpose: MicroRNAs are important immune regulators of gene and protein expression. Both circulating and intragraft expression of microRNAs have been related to renal allograft rejection.…2017 American Transplant Congress
Immune Activation and Rejection Risk in HIV-Positive Kidney Transplantation.
Division of Transplantation, University of California, San Francisco, San Francisco, CA
Purpose: HIV+ kidney transplant recipients experience higher rates of rejection episodes when compared to HIV- recipients. We hypothesize that this early, aggressive rejection is associated…2017 American Transplant Congress
C-C Chemokine Receptor 5 Polymorphisms and Risk of Antibody-Mediated Rejection in Renal Transplantation.
Antibody-mediated rejection (AMR) is the leading cause of graft failure after kidney transplantation. C-C Chemokine receptor 5 (CCR5) plays an important role in immune cell…2017 American Transplant Congress
Early Rejection in the Elderly: Is It Predictable?
University of Maryland Medical Center, Baltimore, MD
Introduction: Optimal induction for elderly kidney transplant recipients (KTR) remains unclear. Older age may be associated with decreased immunogenicity; however, clinical heterogeneity of the elderly…2017 American Transplant Congress
Time to First Therapeutic Tacrolimus Level: What Impact Does It Have After Heart Transplantation?
University of Pittsburgh Medical Center, Pittsburgh, PA
Purpose: Appropriate time to therapeutic immunosuppression levels is not well defined. The purpose of this study is to investigate outcomes related to time to therapeutic…2017 American Transplant Congress
Soluble Fibrinogen-Like Protein 2 Regulates Differentiation and Enhances Immunosuppressive Function of Myeloid-Derived Suppressor Cells in Allograft Immunity.
Urology, Zhongshan Hospital, Fudan University, Shanghai, China
Soluble fibrinogen-like protein 2 (sFGL2) is a novel immunoregulatory molecule, secreted mainly by regulatory T cells. CD11b+ Gr1+ myeloid-derived suppressor cells (MDSCs) are an important…2017 American Transplant Congress
Pro Inflammatory Transitional B (TrB) Cells Characterize Renal Allograft Recipients with DSA and T Cell Mediated Rejection (TCMR).
De novo DSA detected post-renal transplantation is associated with adverse outcomes. We have shown that de novo DSA is strongly associated with TCMR. In this…2017 American Transplant Congress
Acute Antibody-Mediated Rejection in Pediatric Liver Transplantation.
Donor-specific antibodies (DSA) and antibody mediated rejection (AMR) are associated with decreased graft survival in pediatric liver transplantation; however, the incidence of AMR is not…2017 American Transplant Congress
Molecular Analysis of Acute Rejection in Formalin-Fixed Paraffin-Embedded Clinical Face Transplant Biopsies.
1Brigham and Women's Hospital, Boston, MA; 2Harvard T.H. Chan School of Publich Health, Boston
BackgroundDiagnosis of acute rejection in face transplants relies on the histological evaluation of allograft skin biopsies using BANFF classification, an approach with significant limitations including…2017 American Transplant Congress
Gene Expression Profiling for the Identification and Classification of Antibody-Mediated Heart Rejection.
Antibody-mediated rejection (AMR) is a major determinant of heart allograft loss. However, the specific effects of anti-HLA antibodies on heart allograft injury have not been…
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