Articles tagged "Rejection"

2017 American Transplant Congress
Endoscopic Ultrasound Guided Biopsy Sampling of the Pancreas Transplant- The Future of Graft Surveillance?
E. Nordheim,¹ V. Paulsen,² A. Lars,² R. Horneland,³ K. Brabrand,⁴ A. Hartmann,¹ T. Jenssen.^1,5
¹Section of Nephrology, Department of Transplantation, Oslo University Hospital, Oslo, Norway; ²Section of Gastroenterology, Department of Transplantation, Oslo University Hospital, Oslo, Norway; ³Department of Transplantation, Oslo University Hospital, Oslo, Norway; ⁴Department of Radiology, Oslo University Hospital, Oslo, Norway; ⁵Metabolic and Renal Research Group, The Arctic University of Norway, Tromsø, Norway
Background:Pancreas transplantation (PTX) can improve morbidity and potentially increase survival in selected patients with brittle diabetes. Development of a successful and safe biopsy monitoring program…
2017 American Transplant Congress
Complement Activating Anti-HLA Antibodies: Identification of Specific Histo-Mmolecular Phenotype of Rejection for Complement-Targeting Therapy.
C. Lefaucheur,¹ B. Sis,² D. Viglietti,¹ L. Hidalgo,² O. Aubert,¹ D. Glotz,¹ C. Legendre,¹ A. Zeevi,³ P. Halloran,² A. Loupy.¹
¹Paris Translational Research Center for Organ Transplantation, Paris, France; ²University of Alberta, Edmonton, Canada; ³University of Pittsburgh Medical Center, Pittsburgh
Addressing the heterogeneity of antibody-mediated allograft rejection by identifying phenotypes based on pathophysiology is critical for improving outcomes in transplantation. We investigated whether complement-binding anti-HLA…
2017 American Transplant Congress
Maximizing the Potential of Treg-Based Therapies for Transplant Rejection via Computational Immune-Modeling: Effect of Dose, Timing, and Distribution.
G. Raimondi,¹ A. Arun,¹ O. Dorabiala,² J. Arciero.³
¹Plastic & Reconstructive Surgery, Johns Hopkins University, Baltimore; ²Mathematics, Pennsylvania State University, Philadelphia; ³Mathematical Sciences, Indiana University-Purdue University Indianapolis, Indianapolis
Purpose. Regulatory T cells (Treg), endogenous regulators of the immune system, have a significant therapeutic potential for prevention of transplant rejection. Experimental evidences however, indicate…
2017 American Transplant Congress
Co-Stimulation Blockade to Minimize and Withdraw Long Term Calcineurin Inhibitors (CNI) in Simultaneous Pancreas and Kidney Transplant (SPK).
P. Stock,¹ R. Mannon,² B. Armstrong,³ D. Ikle,³ M. Robian,⁴ Y. Morrison,⁴ J. Odorico,⁵ J. Fridell,⁶ A. Mehta,⁷ K. Newell.⁷
¹UCSF, San Francisco; ²UAB, Birmingham, AL; ³Rho Inc, Chapel Hill, NC; ⁴NIH/NIAID, Bethesda, MD; ⁵UW, Madison, WI; ⁶IU, Indianapolis, IN; ⁷Emory University, Atlanta, GA
The NIH multicenter CTOT-15 trial tested the hypothesis that use of belatacept (bela) could minimize or eliminate long-term CNI use in simultaneous pancreas and kidney…
2017 American Transplant Congress
DSA Presence Does Not Affect Renal Histology and Clinical Outcome in Chronic Active Antibody Mediated Rejection.
K. Sablik,¹ M. Clahsen–van Groningen,¹ C. Looman,¹ J. Damman,¹ D. Roelen,² M. van Agteren,¹ M. Betjes.¹
¹Erasmus MC, Rotterdam, Netherlands; ²Leiden UMC, Leiden, Netherlands
Introduction. Chronic active antibody mediated rejection (caABMR) is a major cause of long term renal allograft dysfunction. It is defined by the presence of microvascular…
2017 American Transplant Congress
Predictive Value of Pre-Transplant Cross-Match Techniques on Living Donor Kidney Transplant Outcomes.
M. Meneghini,¹ E. Melilli,¹ I. Revuelta,³ R. Rajalingam,² E. Rigol,⁴ S. Chandran,² F. Diekmann,³ F. Vincenti,² J. Cruzado,¹ J. Martorell,⁴ O. Bestard.¹
¹Kidney Transplant Unit, Bellvitge University Hospital; IDIBELL, Barcelona, Spain; ²Kidney Transplant Unit, UCSF Medical Centre, SanFrancisco; ³Kidney Transplant Unit, Clinic University Hospital, Barcelona, Spain; ⁴Immunology Department, Clinic University Hospital, Barcelona, Spain
Study aim: To investigate the impact of different cross-match techniques and their combination before living-donor kidney transplantation(LDKT) on main clinical outcomes.Methods: Retrospective study including 394…
2017 American Transplant Congress
Integrative Analysis of ExomeSeq and Gene Expression Data for Identification of Novel Variants Associated with Antibody-Mediated Rejection in Kidney Transplant.
S. Pineda,^1,2 T. Sigdel,² A. Jackson,³ M. Sirota,^1,2 M. Sarwal.²
¹Institute for Computational Health Science, University of California, San Francisco (UCSF), San Francisco, CA; ²Department of Surgery, University of California, San Francisco (UCSF), University of California, San Francisco (UCSF), CA; ³Department of Medicine, Johns Hopkins, Baltimore, MD
Background: The objective of this work is to characterize the impact of the donor-recipient (D/R) HLA and non-HLA mismatches on the risk of antibody-mediated rejection…
2017 American Transplant Congress
Transcript Changes Associated with Graft Rejection Are Not Specific for Rejection Because They Are Shared with Tissue Responses to Wounding.
P. Halloran, K. Famulski, INTERCOMEX Study Group.
University of Alberta, Edmonton, Canada
The diagnosis of rejection by histology is based on the presence of relatively non-specific lesions. This is because the histology lesions are actually non-specific, but…
2017 American Transplant Congress
Triptolide Alleviating Acute Antibody Mediated Rejection by Inhibition of B Cell Activation in Presensitized Recipients.
D. Zhao,¹ S. Li,¹ T. Liao,¹ Y. Wei,² X. Hua,¹ F. Han,¹ Z. Luo,¹ X. Liu,¹ Q. Sun.
¹Kidney Transplantation, Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China; ²Key Laboratory of Gene Engineering of the Ministry of Education, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China
Backgroud: Acute antibody mediated rejection (AMR), resistant to most anti-rejection therapy, is main cause for renal graft loss. Triptolide(TPL) had been reported as a promising…
2017 American Transplant Congress
Post-Transplant Lymphoproliferative Disorder: Risk Analysis for Pancreas Transplant Patients.
E. Minja, T. Dunn, A. Matas, T. Pruett, R. Kandaswamy, E. Finger.
Dept of Surgery, University of Minnesota, Minneapolis, MN
Objective: Determine incidence, risk factors, and impact of PTLD in pancreas transplantation (PTx).Methods: Retrospective review of all PTx performed between 7/25/1978 and 12/17/2015 at a…