2018 American Transplant Congress
Clinical Significance and Therapeutic Potential of Orosomucoid 1 for Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients
［Background］We reported a molecular mechanism to develop chronic inflammation (CI), called the inflammation amplifier (IA). IA is activated by concomitant activation of NFkB and STAT3…2018 American Transplant Congress
C1q-Binding Donor-Specific Anti-HLA Antibodies for Clinical Decision Making in Kidney Recipients with Antibody-Mediated Rejection Receiving Standard of Care Treatment
One of the major issues in the clinical management of kidney recipients with ABMR is the lack of early and reliable markers that surrogate long-term…2018 American Transplant Congress
Antibody Mediated Kidney Transplant Rejection Treated with Bortezomib – Case Series from a Single Center
Acute antibody mediated kidney transplant rejection (ABMR) is not a frequent complication but may have a catastrophic consequences for graft survival. Between January 2015 and…2018 American Transplant Congress
Reduction in Circulating CD19+CD24+CD27+ Regulatory B Cell Frequency Predicts Acute Rejection in Liver Transplant Patients
Liver Transplant Center, First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Background: Accumulating evidence suggests that regulatory B cells (Bregs) play an important role in modulating inflammation and autoimmune diseases. However, whether Bregs regulate acute liver…2018 American Transplant Congress
Higher Rates of Rejection in HIV-Infected Kidney Transplant Recipients on Ritonavir-Boosted Protease Inhibitors–Three-Year Follow Up
The Mount Sinai Hospital, New York.
Background: One-year rejection rates in HIV-infected kidney transplant recipients range from 15-40%, compared to overall rejection rates of 10% in HIV-negative patients. Protocols for immunosuppression…2018 American Transplant Congress
Functional Reconstruction of Urogenital Tissue Defects Using VCA: A Novel Microsurgical Penis Transplant Model and Clinical & Histological Rejection Classification
Background: Defects of male urogenital structures subsequent to major trauma are associated with severely reduced function and quality-of-life. As of recent, penis transplantation represents an…2018 American Transplant Congress
12-Months Evolution of Anti-HLA Antibodies Donor Specific Antibodies after Rescue Switch from CNi-Based Immunosuppressive Regimen to Belatacept in Kidney Allograft Recipients
IntroductionAfter kidney transplantation, long-term immunosuppression with calcineurin inhibitors (CNIs) or mTOR inhibitors (mTORi) leads to adverse effects, such as nephrotoxicity and proteinuria. Currently, available data…2018 American Transplant Congress
Monitoring of Small Bowel Allografts with Kynurenine Serum Levels
Long-term success in intestinal transplantation could be significantly improved by the development of a reliable noninvasive marker of rejection, allowing early diagnosis and treatment without…2018 American Transplant Congress
Clinically Relevant Variation of Donor-Derived Cell-Free DNA during Longitudinal Surveillance of Renal Allografts
Purpose: Donor-derived cell-free DNA (dd-cfDNA) levels >1% are associated with active rejection in renal transplant recipients. This report defines the clinically relevant variation of dd-cfDNA…2017 American Transplant Congress
Extended Experience with Tocilizumab (Anti-IL6R) for Difficult to Desensitize (Des) Patients Awaiting HLA Incompatible Kidney Transplant.
Kidney Transplant, Cedars-Sinai Medical Center, LA, CA
INTRODUCTION: ~30% of HS patients fail to respond to DES with IVIG+rituximab. IL6/IL-6R signaling is critical for B-cell differentiation to plasmablasts and IgG production. Tocilizumab…
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