ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2018 American Transplant Congress

    Elucidating Novel Signatures of Allograft Rejection through Cytometry by Time of Flight (CyTOF) in Kidney Transplant Recipients

    S. Eskandari,1 B. Al Dulaijan,1 J. Assaker,1 L. Riella,1 A. Kurdi,2 J. Azzi.1

    1Transplantation Research Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA; 2Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA.

    Mass cytometry by time-of-flight (CyTOF) permits the simultaneous assessment of over 40 functional and phenotypic parameters at the single-cell level. This novel tool holds tremendous…
  • 2018 American Transplant Congress

    Repeat Kidney Transplant Patients with Active Rejection Have Elevated Donor-Derived Cell-Free DNA

    S. Mehta,1 J. Chang,2 T. Hailey,1 D. Hiller,3 M. Grskovic,3 J. Yee,3 R. Mannon.1

    1University of Alabama School of Medicine, Birmingham, AL; 2Columbia University Medical Center, New York, NY; 3CareDx, Brisbane, CA.

    Purpose: Donor-derived cell-free DNA (dd-cfDNA) is an established marker of active rejection in de novo kidney transplant recipients. Here we characterize dd-cfDNA in patients who…
  • 2018 American Transplant Congress

    Interstitial Inflammation is Correlated with DQ Antibodies in Kidney Transplant Recipients

    C. Harris, L. Anderson, R. Khaim, J. Choudhuri, R. Shapiro, S. Florman, F. Salem, M. Menon.

    Icahn School of Medicine at Mount Sinai, New York.

    Background: Studies have shown that borderline rejection (BR) and acute cellular rejection (ACR) often co-occur with antibody-mediated rejection (AMR). We examined the association between interstitial…
  • 2018 American Transplant Congress

    Characterization of Renal Allograft Tolerance Induction via Transient Mixed Chimerism in Non-Human Primates

    H. Sasaki,1 C. Thaiss,1 T. Oura,1 A. Rosales,2 R. Smith,2 R. Colvin,2 B. Cosimi,1 T. Kawai.1

    1Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston; 2Pathology, Massachusetts General Hospital, Boston.

    Background: We have previously reported long-term renal allograft tolerance after induction of transient mixed chimerism in non-human primates. However, some recipients developed late onset chronic…
  • 2018 American Transplant Congress

    The Combination of pAMR and Circulating Donor-Specific Antibodies is Even More Associated with Cardiac Allograft Vasculopathy after Heart Transplant

    J. Patel, M. Kittleson, E. Kransdorf, S. Dimbil, R. Levine, D. Geft, D. Chang, L. Czer, J. Kobashigawa.

    Cedars Sinai Medical Center, Los Angeles.

    Purpose: Several reports have correlated the development of donor-specific antibody (DSA) to the development of cardiac allograft vasculopathy (CAV) after heart transplantation (HTx). Interestingly, patients…
  • 2018 American Transplant Congress

    Analysis of Rabbit Anti-Thymocyte Globulin versus Basiliximab Induction in Pediatric Liver Transplant Recipients

    D. Newland,1 M. Royston,1 D. McDonald,1 K. Wallace-Boughter,2 T. Németh,1 K. Carlin,3 S. Horslen.2

    1Pharmacy, Seattle Children's Hospital, Seattle, WA; 2Pediatrics, UW School of Medicine, Seattle, WA; 3Seattle Children's Research Institute, Seattle.

    Background: Literature is limited comparing rabbit anti-thymocyte globulin (rATG) versus basiliximab (BSX) induction in pediatric liver transplant (LT) recipients in the setting of modern-day maintenance…
  • 2018 American Transplant Congress

    De Novo Donor Specific Antibodies in Pediatric Kidney Transplant Recipients Are Highly Responsive to Therapy

    V. Sigurjonsdottir, P. Grimm.

    Pediatric Nephrology, Lucile Packard Children´s Hospital, Palo Alto, CA.

    Background: Pediatric Kidney transplant recipients who develop dnDSAs are at increased risk of allograft loss and rapid decline in GFR. C1q+ DSA, in particular, is…
  • 2018 American Transplant Congress

    Circulating Exosomes with Lung Self-Antigens, Kα1Tubulin and Collagen V, and Immunoregulatory Molecules Are Present in Bronchiolitis Obliterans Syndrome Following Pediatric Lung Transplantation

    M. Sharma,1 L. Danziger-Isakov,2 P. Heeger,3 S. Sweet,4 T. Mohanakumar.1

    1Norton Thoracic Insitute, St. Joseph's Hosp & Med Ctr, Phoenix; 2Cincinnati Children's Hosp Med Ctr, Cincinnati; 3Icahn Sch Med at Mt Sinai, New York; 4Washington Univ Sch Med, St. Louis.

    Exosomes containing mismatched donor HLA and lung restricted self-antigens (SAgs), Kα1 Tubulin (Kα1T) and Collagen V (Col-V), have demonstrated in sera and bronchoalveolar lavage fluid…
  • 2018 American Transplant Congress

    Outcomes of Kidney Transplant Recipients with Early Allograft Inflammation: A Prospective Study

    R. Mehta, S. Tandukar, P. Sood, C. Puttarajappa, C. Wu, N. Shah, A. Tevar, S. Hariharan.

    University of Pittsburgh Medical Center, Pittsburgh.

    The impact of early allograft inflammation is unclear. We prospectively studied changes in renal function and histology in a cohort of patients who received a…
  • 2017 American Transplant Congress

    Pre-Transplant Evaluation of KSORTSM to Assess Risk for Rejection in Highly Sensitized Patients.

    S. Nandoe,1 S. Roedder,3 S. Hsieh,1 T. Sigdel,1 P. Lindner,4 J. Ekberg,4 J. Alberu,5 F. Vincenti,1 M. Sarwal.1

    1UCSF, San Francisco, CA; 2Immucor, Norcross, GA; 3Gothenburg University, Gothenburg, Sweden; 4Salvador Zubiran, Mexico City, Mexico

    Study purpose: To investigate the kSORTSM molecular expression assay for immune risk assessment in renal transplant (tx) recipients prior to tx for correlation of pre-tx…
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