2018 American Transplant Congress
Bortezomib in Late Antibody-Mediated Kidney Transplant Rejection – A Double-Blind Randomized Placebo-Controlled Trial (BORTEJECT Study)
Background. Antibody-mediated rejection (ABMR) is a leading cause of long-term kidney transplant loss. Optimal treatment of late ABMR is unclear, and our current knowledge is…2018 American Transplant Congress
Dual Inhibition of PI3K and mTORC2 Causes ERK Hyperactivation Induced by HLA-II Antibody in Human Endothelium
Pathology and Laboratory Medicine, David Geffen School of Medicine, UCLA, Los Angeles, CA.
Background: Endothelial cells (EC) line the inner surface of blood vessels and serve as the interface between recipient circulating blood and the donor allograft. Transplant…2018 American Transplant Congress
The Risk Factors of Acute Rejection in Patients with BK Nephropathy after the Reduction of Immunosuppression
Background: BK nephropathy (BKN) affects graft function and increases the risk of graft failure. The reduction of immunosuppression is the main treatment for BKN. However,…2018 American Transplant Congress
The Inhibitory Effect of Plasma on Activation of Lymphocytes from Kidney Transplants is Significantly More Severe in Tacrolimus Based Regimen: What Implications for Plasma Exchange Role in Anti-Rejection Therapy?
Background:Reduction of lymphocyte proliferation by human plasma has been previously reported. Reduced activation of lymphocytes of patients on immunosuppressive drugs is well documented. However, trial…2018 American Transplant Congress
Defining Response to Standard of Care Treatment in Kidney Recipients with Antibody-Mediated Rejection: Role of C1q-Binding Donor-Specific Anti-HLA Antibodies
Paris Translational Research Center for Organ Transplantation, Paris, France.
A major hurdle to improving clinical care in kidney transplantation is the lack of biomarkers of the response to antibody-mediated rejection (ABMR) treatment. We investigated…2018 American Transplant Congress
Urinary Chemokine CXCL-10 in Long Term Renal Transplant Patients Associates with Urinary Tract Infections and Microvascular Damage
Non-invasive biomarkers are needed to predict rejection post kidney transplantation. In the early transplant period, urinary CXCL-9 and CXCL-10 associate with rejection. We assessed the…2018 American Transplant Congress
Rejection and Graft Loss in Patients with BK Viremia after Simultaneous Pancreas and Kidney Transplant
University of Minnesota, Minneapolis, MN.
Background: BK virus is a recognized cause of kidney allograft dysfunction. The treatment of BK is immunosuppression reduction. This reduction in patients with a simultaneous…2018 American Transplant Congress
Targeting Histone Deacetylase in Renal Tubular Epithelial Cells Inhibits Amplification of TH1 Cell-Mediated Inflammation
Inje University, Busan, Korea.
Background: Objective: More studies are focusing on renal tubular epithelial cells (RTECs) as a new target to restore inflammatory environment as clarifying their immune regulatory…2018 American Transplant Congress
Predicting Pediatric Liver Transplant Rejection with Peripheral Blood Leukocyte (PBL) Transcripts-Considerations and Design Limitations
Pediatric Abdominal Transplant, Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA.
Background: Optimizing immunosuppression requires individualized rejection-risk assessment in children with liver transplantation (LTx). PBL transcripts are a desirable non-invasive solution. Purpose: To characterize PBL transcriptome…2018 American Transplant Congress
FSGS Pattern with Podocyte Proliferation and Heavy Proteinuria Combined Late Antibody Mediated Rejection of Renal Allograft: Collapsing Glomerulopathy or Transplant Podocytopathy?
Background: Collapsing Glomerulopathy is a pathologically and clinically distinct variant of FSGS with poor prognosis.Hemodynamic disturbances may play a role in the development of the…
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