ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Rejection"

  • 2018 American Transplant Congress

    Interstitial Inflammation is Correlated with DQ Antibodies in Kidney Transplant Recipients

    C. Harris, L. Anderson, R. Khaim, J. Choudhuri, R. Shapiro, S. Florman, F. Salem, M. Menon.

    Icahn School of Medicine at Mount Sinai, New York.

    Background: Studies have shown that borderline rejection (BR) and acute cellular rejection (ACR) often co-occur with antibody-mediated rejection (AMR). We examined the association between interstitial…
  • 2018 American Transplant Congress

    Characterization of Renal Allograft Tolerance Induction via Transient Mixed Chimerism in Non-Human Primates

    H. Sasaki,1 C. Thaiss,1 T. Oura,1 A. Rosales,2 R. Smith,2 R. Colvin,2 B. Cosimi,1 T. Kawai.1

    1Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Boston; 2Pathology, Massachusetts General Hospital, Boston.

    Background: We have previously reported long-term renal allograft tolerance after induction of transient mixed chimerism in non-human primates. However, some recipients developed late onset chronic…
  • 2018 American Transplant Congress

    The Combination of pAMR and Circulating Donor-Specific Antibodies is Even More Associated with Cardiac Allograft Vasculopathy after Heart Transplant

    J. Patel, M. Kittleson, E. Kransdorf, S. Dimbil, R. Levine, D. Geft, D. Chang, L. Czer, J. Kobashigawa.

    Cedars Sinai Medical Center, Los Angeles.

    Purpose: Several reports have correlated the development of donor-specific antibody (DSA) to the development of cardiac allograft vasculopathy (CAV) after heart transplantation (HTx). Interestingly, patients…
  • 2018 American Transplant Congress

    Analysis of Rabbit Anti-Thymocyte Globulin versus Basiliximab Induction in Pediatric Liver Transplant Recipients

    D. Newland,1 M. Royston,1 D. McDonald,1 K. Wallace-Boughter,2 T. Németh,1 K. Carlin,3 S. Horslen.2

    1Pharmacy, Seattle Children's Hospital, Seattle, WA; 2Pediatrics, UW School of Medicine, Seattle, WA; 3Seattle Children's Research Institute, Seattle.

    Background: Literature is limited comparing rabbit anti-thymocyte globulin (rATG) versus basiliximab (BSX) induction in pediatric liver transplant (LT) recipients in the setting of modern-day maintenance…
  • 2018 American Transplant Congress

    De Novo Donor Specific Antibodies in Pediatric Kidney Transplant Recipients Are Highly Responsive to Therapy

    V. Sigurjonsdottir, P. Grimm.

    Pediatric Nephrology, Lucile Packard Children´s Hospital, Palo Alto, CA.

    Background: Pediatric Kidney transplant recipients who develop dnDSAs are at increased risk of allograft loss and rapid decline in GFR. C1q+ DSA, in particular, is…
  • 2018 American Transplant Congress

    Circulating Exosomes with Lung Self-Antigens, Kα1Tubulin and Collagen V, and Immunoregulatory Molecules Are Present in Bronchiolitis Obliterans Syndrome Following Pediatric Lung Transplantation

    M. Sharma,1 L. Danziger-Isakov,2 P. Heeger,3 S. Sweet,4 T. Mohanakumar.1

    1Norton Thoracic Insitute, St. Joseph's Hosp & Med Ctr, Phoenix; 2Cincinnati Children's Hosp Med Ctr, Cincinnati; 3Icahn Sch Med at Mt Sinai, New York; 4Washington Univ Sch Med, St. Louis.

    Exosomes containing mismatched donor HLA and lung restricted self-antigens (SAgs), Kα1 Tubulin (Kα1T) and Collagen V (Col-V), have demonstrated in sera and bronchoalveolar lavage fluid…
  • 2018 American Transplant Congress

    Outcomes of Kidney Transplant Recipients with Early Allograft Inflammation: A Prospective Study

    R. Mehta, S. Tandukar, P. Sood, C. Puttarajappa, C. Wu, N. Shah, A. Tevar, S. Hariharan.

    University of Pittsburgh Medical Center, Pittsburgh.

    The impact of early allograft inflammation is unclear. We prospectively studied changes in renal function and histology in a cohort of patients who received a…
  • 2018 American Transplant Congress

    Treatment of Post Transplant Hepatitis C (HCV) with Direct-Acting Antiviral (DAA) Agents May Improve Liver Function but Does Not Lead to an Increase in Liver Rejection

    P. Sheiner, N. Mello, G. Baixauli, M. Einstein, C. Rochon, Y. Kwon, M. Bejon.

    Surgery, Hartford Hospital, Hartford, CT.

    Previous studies have suggested that with the use of with (DAA) agents to treat post transplant (HCV), there has been an increased incidence of liver…
  • 2018 American Transplant Congress

    Class II Anti-HLA IgG2 and IgG3 DSAs Predict Poorer Outcomes in Chronic Antibody Mediated Rejection of Renal Allografts

    A. Gueret-Wardle,1 G. Lucisano,1 S. Hassan,1 P. Brookes,2 E. Santos-Nunez,2 D. Goodall,1 C. Clarke,1 J. Galliford,1 M. Willicombe,1 D. Taube.1

    1Renal and Transplant Centre, Imperial College London NHS Trust, London, United Kingdom; 2Histocompatibility and Immunogenetics, Imperial College London, London, United Kingdom.

    Introduction: whilst the development of IgG3 and C1q binding de novo [dn] HLA DSAs are associated with a poor outcome in acute antibody mediated rejection,…
  • 2018 American Transplant Congress

    A Follow-Up Report on the Use of IVIG+Rituximab to Reduce Donor Specific Antibodies and Improve Transplant Rates in Highly-Sensitized Patients Awaiting Deceased Donor Kidney Transplantation

    R. Najjar, E. Huang, A. Vo, J. Choi, K. Lim, S. Louie, A. Peng, S. Sethi, M. Toyoda, X. Zhang, S. Jordan.

    Medicine/Nephrology, Cedars Sinai Medical Center, Los Angeles, CA.

    Introduction: Desensitization (DES) with IVIG/rituximab is associated with a reduction in donor specific antibodies (DSA), improved transplant rates and outcomes in highly-sensitized (HS) patients. We…
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