Articles tagged "Rejection"

2018 American Transplant Congress
Pre-Transplant versus De Novo Donor Specific Antibodies: Differences in Clinical Outcomes and Antibody Mediated Rejection
M. Ajaimy, N. Hayde, A. Colovai, E. Akalin.
Montefiore-Einstein Transplant Center, Montefiore-Einstein Transplant Center, Bronx.
Background: Antibody mediated rejection (ABMR) can occur through pre-transplant(tx) vs. de novo donor specific antibodies (DSA). Clinical outcomes, allograft injury and dynamics of DSAs have…
2018 American Transplant Congress
Incidence of Rejection and Antibody Formation after Immunosuppression Reduction in Patients with Biopsy Proven Polyomavirus Nephropathy
M. Kleman, R. Detwiler, H. Singh, V. Nickeleit.
University of North Carolina, Chapel Hill, NC.
The purpose of this study is to determine the incidence of rejection and donor specific antibody (DSA) formation after immunosuppression reduction in patients with biopsy…
2018 American Transplant Congress
The Effects of Age-Adjusted Marriage Duration on Graft Outcomes in Spousal Donor Kidney Transplantation
M. Yu,¹ J. Park,² H. Cho,¹ J. Ha,¹ C. Ahn,¹ Y. Kim,¹ H. Lee.¹
¹Seoul National University Hospital, Seoul, Korea; ²Kangwon National University Hospital, Chuncheon, Korea.
It is well known that graft survival rate in spousal donor kidney transplantation (SKT) is similar to that of living related donor kidney transplantation (LRKT)…
2018 American Transplant Congress
Delivery of Culturally-Competent Transplant Care among Hmong Kidney Transplant Recipients: Outcomes from a Single Institution
M. Odegard,¹ O. Serrano,¹ K. Peterson,¹ S. Mongin,² D. Berglund,³ D. Vock,⁴ S. Chinnakotla,¹ T. Dunn,¹ E. Finger,¹ R. Kandaswamy,¹ T. Pruett,¹ A. Matas.¹
¹Division of Transplantation, Division of Surgery, University of Minnesota, Minneapolis, MN; ²Biostatistical Design and Analysis Center, Clinical and Translational Science Institute, University of Minnesota, Minneapolis, MN; ³Informatics Services for Research and Reporting, Fairview, University of Minnesota, Minneapolis, MN; ⁴Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN.
OBJECTIVE: Kidney transplantation (KT) entails delivery of complex, well-coordinated, multidisciplinary care. Cultural and linguistic discordance among transplant providers and patients can lead to healthcare disparities.…
2018 American Transplant Congress
mRNA Transcript Profiles of 14 Genes in Plasma Exosome Predict Risk for Antibody-Mediated Rejection (ABMR) of Renal Allografts
H. Zhang,¹ E. Huang,² C. Nast,³ J. Kahwaji,² A. Vo,² S. Jordan,² M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ³Pathology, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Previously we reported that mRNA transcript profiles of 4 genes (gp130, SH2D1B, TNFα and CCL4) in plasma exosome could predict the risk of ABMR,…
2018 American Transplant Congress
Elevated Skin Specific Non-HLA Antibodies Correlate with Acute Rejection Episodes in Clinical VCA
B. Kollar,¹ A. Uffing,² T. Win,¹ S. Tasigiorgos,¹ B. Pomahac,¹ F. Quintana,³ L. Riella.²
¹Division of Plastic Surgery, Brigham and Women's Hospital, Boston, MA; ²Transplantation Research Center, Brigham and Women's Hospital, Boston, MA; ³Ann Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA.
Introduction: Vascularized composite allotransplantation (VCA) is unique by presence of the skin in the allografts. Due to the high immunogenicity of skin and the presence…
2018 American Transplant Congress
Unsupervised Analysis of the Alloimmune Response in a Novel Model of Vascularized Composite Allotransplantation
J. Harden, A. Sang, X. Qu, C. Esquivel, O. Martinez, S. Krams.
Department of Surgery/Division of Abdominal Transplantation, Stanford University, Stanford, CA.
Vascularized composite allografts consists of skin, muscle, bone, and other tissues, and is more immunogenic than solid-organ allografts. Our laboratory developed a murine model to…
2018 American Transplant Congress
IL-6 Inhibition with Tocilizumab to Promote Tregs and Control Renal Graft Inflammation: A Prospective Randomized Controlled Trial
S. Chandran, J. Leung, Z. Laszik, Q. Tang, C. Hu, M. Sarwal, F. Vincenti.
UCSF, San Francisco.
Background: IL-6, a proinflammatory cytokine & key regulator of Treg/Th17, is strongly associated with renal graft rejection. In theory, IL-6 blockade with tocilizumab (TCZ), a…
2018 American Transplant Congress
Non-Invasive Proteomics to Detect Biomarkers for Kidney Allograft Dysfunction
M. Watson,¹ M. Srivastava,³ D. Little,¹ O. Eidelman,³ R. Nee,¹ A. Bera,³ J. Karaian,³ D. Oliver,¹ H. Pollard,³ R. Jindal.²
¹Nephrology, USU-Walter Reed, Bethesda, MD; ²Surgery, USU-Walter Reed, Bethesda, MD; ³Anamtomy, Physiology and Genetics, USU-School of Medicine, Bethesda, MD.
Background: Non-invasive biomarkers are needed for monitoring patients to predict early acute rejection (AR). We hypothesized that protein biomarkers released from rejecting allograft tissues can…
2018 American Transplant Congress
Significance of Antibody-Mediated Vascular Rejection (AMVR) on Graft Survival: Correlation with Pure Antibody-Mediated Rejection (AMR)
B. Ozdemir,¹ F. Ozdemir,² A. Terzi,² G. Ozdemir,¹ A. Ok Atilgan,¹ E. Ayvazoglu Soy,³ A. Akdur,³ G. Moray,³ M. Haberal.³
¹Pathology, Baskent University, Ankara, Turkey; ²Nephrology, Baskent University, Ankara, Turkey; ³Transplantation, Baskent University, Ankara, Turkey.
Introduction: The importance of the endarteritis on graft survival in recipients with AMR is controversial. Thus we aimed to understand the prognostic value of the…