2018 American Transplant Congress
Belatacept in Kidney Transplant Recipients with Preformed Donor Specific Anti-HLA Antibodies: Results of the BELACOR Trial
IntroductionAntibody-mediated rejection (ABMR) is currently a critical question in kidney transplant recipient with immunological risk factors such as pre transplant donor-specific anti HLA antibodies (DSA).…2018 American Transplant Congress
Chronic Antibody Mediated Rejection in Renal Allografts Shows RNA Transcript Patterns That Evolve with Stage
1Massachusetts General Hospital, Boston, MA; 2University of Alberta, Edmonton, AB, Canada.
Purpose. Four stages of chronic antibody mediated rejection (CAMR) in renal allografts have been defined in humans and non-human primates (NHP), beginning with donor specific…2018 American Transplant Congress
Macrophage Depletion of RCMV-Latently Infected Allografts Ameliorates Accelerated Chronic Cardiac Rejection
1Abdominal Organ Transplantation, OHSU, Portland, OR; 2VGTI, OHSU, Portland, OR.
PurposeLatent donor rat cytomegalovirus (RCMV) infection accelerates chronic rejection (CR) in a heterotopic rat heart transplant model. RCMV latency is associated with an influx of…2018 American Transplant Congress
Specific Monocyte Memory to Allogeneic MHC Mediated by Paired Immunoglobulin Receptors (PIR)
Monocytes distinguish between self and allogeneic non-self and contribute to allograft rejection by generating mature, IL-12+, DCs. The initial trigger of monocyte differentiation to DCs…2018 American Transplant Congress
Influence of X-Ray Repair Cross-Complementing Group (XRCC) Genes Polymorphisms on the Development of Antibody-Mediated Rejection (ABMR) in Renal Transplant Recipients
The importance of antibody-mediated rejection (ABMR) on the renal transplant recipients has been recognized in recent years. However, the pathogenesis of ABMR following kidney transplantation…2018 American Transplant Congress
Clinical Response to Salvage Bortezomib Therapy for Antibody Mediated Rejection and Mixed Acute Rejection in a High Immunologic Risk Renal Transplant Population
University of Illinois at Chicago, Chicago, IL.
Background: Proteasome inhibitor (PI) containing regimens treat antibody mediated rejection (AMR) and mixed acute rejection (MAR) due to elimination of donor specific antibody (DSA). Commonly,…2018 American Transplant Congress
Pre-Emptive Rituximab and Intravenous Immunoglobulin (IVIg) Fail to Prevent Rejection in Kidney Transplant Recipients (KTx) with Donor Specific Antibodies (DSA)
Columbia University, New York, NY.
Introduction:IVIg and Rituximab have been used successfully to improve transplantation rates in sensitized patients. DSA detected by Flow crossmatch (FXM+) or Luminex® at time of…2018 American Transplant Congress
Comparative Analysis of Alloantigen-Stimulated Gene Expression in HIV(+) Liver Transplant Rejectors versus Non-Rejectors
Surgery, University of California, San Francisco, San Francisco, CA.
In a multi-center, prospective trial of solid-organ transplantation in persons with HIV, recipients had a 2-3x increased rejection rate when compared to historical data on…2018 American Transplant Congress
Urinary Proteomics as a Dignostic Mean for Chronic Humoral Rejection after Pediatric Kidney Transplantation
Chronic antibody-mediated rejection (cAMR) is the main cause of long-term graft loss and presents a diagnostic challenge in renal transplantation medicine. Late-stage diagnosis is made…2018 American Transplant Congress
NKG2C+CD57+ NK (G2C+57+) Cells Expanded by CMV Infection Are Highly Responsive to Allo-Antibody (Ab)-Mediated NK Cell Stimulation
Introduction: Active CMV infection is known to be associated with risk for ABMR in allograft recipients. Ab-dependent cellular cytotoxicity (ADCC) primarily mediated by NK cells…
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