2018 American Transplant Congress
Intragraft Gene Expression Differentiates Polyomavirus Nephropathy from T-Cell Mediated Rejection
Background: Improved immunosuppression protocols have reduced the incidence of T-cell mediated rejection (TCMR) but still carry a significant risk of BK polyomavirus nephropathy (BKVN). Despite…2018 American Transplant Congress
Bioinformatics Approach to the Development of a Novel Molecular Biomarker for Sub-Clinical Acute Rejection (subAR) in the Peripheral Blood Following Kidney Transplant (KT)
Sub-clinical acute rejection (subAR) following KT is associated with poor long-term graft outcomes and can only be detected using invasive surveillance biopsies (SBx). Non-invasive biomarker…2018 American Transplant Congress
Urinary C-X-C Motif Chemokines 13 is a Noninvasive Biomarker of Antibody-Mediated Renal Allograft Rejection
Background: Since acute rejection remains one of the major complications which necessitate periodic surveillance, noninvasive diagnostic/prognostic methods are preferred by renal transplant recipients. Here we…2018 American Transplant Congress
Impact of Pretransplant Donor-Specific Antibodies on Kidney Allograft Recipients with Negative Flow Cytometry Crossmatches
Asan Medical Center, Seoul, Korea.
This study evaluated the impact of DSA on clinical outcomes in KT recipients negative on FCXM. Of 575 consecutive patients who underwent living donor KT…2018 American Transplant Congress
Characterization of Renal Allograft Tolerance Induction via Transient Mixed Chimerism in Non-Human Primates
Background: We have previously reported long-term renal allograft tolerance after induction of transient mixed chimerism in non-human primates. However, some recipients developed late onset chronic…2018 American Transplant Congress
The Combination of pAMR and Circulating Donor-Specific Antibodies is Even More Associated with Cardiac Allograft Vasculopathy after Heart Transplant
Cedars Sinai Medical Center, Los Angeles.
Purpose: Several reports have correlated the development of donor-specific antibody (DSA) to the development of cardiac allograft vasculopathy (CAV) after heart transplantation (HTx). Interestingly, patients…2018 American Transplant Congress
Analysis of Rabbit Anti-Thymocyte Globulin versus Basiliximab Induction in Pediatric Liver Transplant Recipients
Background: Literature is limited comparing rabbit anti-thymocyte globulin (rATG) versus basiliximab (BSX) induction in pediatric liver transplant (LT) recipients in the setting of modern-day maintenance…2018 American Transplant Congress
De Novo Donor Specific Antibodies in Pediatric Kidney Transplant Recipients Are Highly Responsive to Therapy
Pediatric Nephrology, Lucile Packard Children´s Hospital, Palo Alto, CA.
Background: Pediatric Kidney transplant recipients who develop dnDSAs are at increased risk of allograft loss and rapid decline in GFR. C1q+ DSA, in particular, is…2018 American Transplant Congress
Circulating Exosomes with Lung Self-Antigens, Kα1Tubulin and Collagen V, and Immunoregulatory Molecules Are Present in Bronchiolitis Obliterans Syndrome Following Pediatric Lung Transplantation
Exosomes containing mismatched donor HLA and lung restricted self-antigens (SAgs), Kα1 Tubulin (Kα1T) and Collagen V (Col-V), have demonstrated in sera and bronchoalveolar lavage fluid…2018 American Transplant Congress
Outcomes of Kidney Transplant Recipients with Early Allograft Inflammation: A Prospective Study
University of Pittsburgh Medical Center, Pittsburgh.
The impact of early allograft inflammation is unclear. We prospectively studied changes in renal function and histology in a cohort of patients who received a…
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