2018 American Transplant Congress
The Role of Donor-Derived Cell-Free DNA in Identification of Injury in Kidney Allografts with Antibody-Mediated Rejection and De Novo DSA
Objectives: To evaluate the capacity of donor-derived cell-free DNA (dd-cfDNA) in the identification of injury in kidney allografts with antibody-mediated rejection and de novo DSA.Methods:…2018 American Transplant Congress
Outcomes of C4d+ Immunostaining in Heart Transplantation: Is All Immunologic AMR Bad?
Cedars Sinai Medical Center, Los Angeles, CA.
Purpose: Antibody-mediated rejection (AMR) remains a threat to patients (pts) following heart transplant (HTx). C4d immunostaining is one component involved in the diagnosis of AMR…2018 American Transplant Congress
Molecular Analysis of Acute Cellular Rejection in Clinical Face Transplants
Brigham and Women's Hospital, Boston.
Although monitoring and immunosuppression of vascularized composite allografts (VCA) draw experience from solid organ transplantation, VCAs pose unique challenges. A deeper understanding of mechanisms underlying…2018 American Transplant Congress
Inflammation in Scarred Areas (i-IF/TA): Defining the Response to Standard Treatment of T Cell-Mediated Rejection in Kidney Recipients
Paris Translational Research Center for Organ Transplantation, Paris, France.
The 2017 Banff meeting has focused on the importance of defining the potential role of i-IF/TA as a component of the T cell-mediated rejection (TCMR)…2018 American Transplant Congress
Serial Monitoring of Resolution of Sub-Clinical Acute Rejection (subAR) in Kidney Transplant Recipients (KTR) Using a Gene Expression Profile (GEP)
BACKGROUNDSubAR can currently only be detected using surveillance biopsies (SBx) and is associated with poor long-term graft outcomes. Response to treatment is difficult to assess.…2018 American Transplant Congress
Validation Study of Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) and Cell-Mediated Rejection (CMR) in Renal Allograft Biopsies (Bx) Suggests Complexity of Molecular Diagnosis for ABMR Compared to CMR
Background: Various molecular signatures specific to ABMR and CMR based on gene expression in renal allograft Bx or peripheral blood mononuclear cells (PBMC) of renal…2018 American Transplant Congress
Diagnostic Usefulness of Medullary C4d Staining in Renal Allografts
Background: Detection of peritubular capillary (PTC) complement C4d on renal allograft biopsy is a histologic marker (along with serum anti-donor antibody, PTC inflammatory cells and…2018 American Transplant Congress
How Should Pancreas Transplant Rejection Be Treated?
Department of Nephrology, University of Wisconsin, Madison.
How Should Pancreas Transplant Rejection be Treated?Background: There is limited information about how to approach the treatment of pancreas rejection, particularly regarding the use of…2018 American Transplant Congress
Improved Mouse Renal Transplantation Model Mimicking Clinical Antibody Mediated Rejection
Antibody mediated rejection (AMR) is main barrier to long term renal graft survival and mouse model is important to understand the mechanisms of AMR and…2018 American Transplant Congress
Protocol Biopsies after Paediatric Kidney Transplantation: A Single Centres' 17 Year Experience
PURPOSE: Standard laboratory measures are not sensitive indicators of kidney dysfunction following transplantation and may be less reliable in paediatric recipients. Early graft surveillance may…
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