Articles tagged "Rejection"

2018 American Transplant Congress
Long Term Histologic Allograft Health is Preserved Despite Rejection during Protocolized Immunosuppression Withdrawal (ISW) in Stable Pediatric Liver Transplant Recipients
V. Venkat,¹ J. Bucuvalas,² M. Martinez,³ K. Spain,⁴ G. Mazariegos,¹ A. Demetris,⁵ S. Feng.⁶
¹Children's Hospital, Pittsburgh; ²CCHMC, Cincinnati; ³Columbia, NY; ⁴Rho, Chapel Hill; ⁵UPMC, Pittsburgh; ⁶UCSF, San Francisco.
Background: Long term allograft health after rejection during ISW has not been previously assessed. We compare baseline and 4yr graft histology of 20 rejectors in…
2018 American Transplant Congress
A Pre-Transplant Blood-Based Lipid Signature for Prediction of Antibody-Mediated Rejection in Kidney Transplant Patients
G. Gupta, S. Bobba, D. Contaifer, P. Kimball, A. King, D. Kumar, M. Levy, J. Stern, D. Wijesinghe.
Virginia Commonwealth University, Richmond.
BACKGROUNDThere is a lack of biomarkers for pre-kidney transplant immune risk stratification to avoid over- or under-immunosuppression. Since the circulating lipidome is integrally involved in…
2018 American Transplant Congress
NK Cells in Allograft Kidney Biopsies during Rejection: Detection, Quantification, and Precise Localization Using Multiplex Immunofluorescence
M. Terada,¹ J. Duong Van Huyen,² F. Drieux,⁴ C. Legendre,³ P. Bruneval,¹ M. Rabant.²
¹Pathology Department, Georges Pompidou European Hospital, Paris, France; ²Pathology Department, Necker-Enfants Malades Hospital, Paris, France; ³Kidney Transplantation Department, Necker-Enfants Malades Hospital, Paris, France; ⁴Pathology Department, Centre Henri Becquerel, Rouen, France.
Introduction: Among the complex cellular interplay engaged in renal rejection, recent transcriptomic analysis of renal biopsies has detected NK cell transcripts in the setting of…
2018 American Transplant Congress
Elevated Levels of CD19⁺ B Cells before or after Rituximab Administration is a Risk Factor for the Early Rejection of a Living Kidney Transplant
M. Kono,¹ H. Shirakawa,² S. Wakai.¹
¹Nephrology, Ohkubo Hospital, Tokyo, Japan; ²Urology, Ohkubo Hospital, Tokyo, Japan.
[Introduction]Rituximab (RTX) is used for desensitization in highly sensitized patients, such as those undergoing ABO-incompatible (ABOi) kidney transplantation. Although RTX is generally effective, some patients…
2018 American Transplant Congress
Intensified Immunosuppression Improves Early Renal Allograft Function after Transplantation in a Porcine Model with Extended Asystolic Warm Ischemic Time
M. Xu,¹ X. Wang,¹ S. Garcia-Aroz,¹ B. Banan,¹ B. Rabe,¹ Z. Zhang,¹ J. Jia,¹ G. Upadhya,¹ P. Manning,² J. Gaut,³ Y. Lin,¹ W. Chapman.¹
¹Department of Surgery, Section of Abdominal Transplantation, Washington University School of Medicine, St. Louis, MO; ²Arch Oncology, St. Louis, MO; ³Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO.
PURPOSE: Extensive ischemia-reperfusion injury significantly increases the immunogenicity of renal allograft which may be associated with increased risk of acute rejection (AR). This study investigated…
2018 American Transplant Congress
Impact of Psychosocial Variables on Renal Allograft Rejection Risk: A Multivariate Analysis
D. Chernobylsky, K. Carsky, C. McDermott, P. Ferrin, R. Fernandez, I. Gaines, M. Killackey, R. Zhang, A. Paramesh, J. Buell.
Transplant Surgery, Tulane University School of Medicine, New Orleans, LA.
Transplant-specific risk factors for rejection are well documented, yet psychosocial variable correlation with rejection risk is not; this analysis seeks to determine the relationship between…
2018 American Transplant Congress
Reassessment of Virtual Crossmatch: The Clinical Meaning of Cell-Based Actual Crossmatch for Kidney Transplantation
B. Peng,^1,2 M. Yu,^1,2 Q. Zhuang,^1,2 H. Liu,^1,2 L. Zhu,^1,2 Y. Liu,^1,2 K. Cheng,^1,2 Y. Ming.^1,2
¹Transplantation Center, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China; ²Engineering & Technology Research Center for Transplantation Medicine, National Ministry of Health, Changsha, Hunan, China.
Background: Due to the high sensitivity and specificity of Luminex technique, the Luminex single antigen beads (LSAB) assays are widely used in detecting the HLA…
2018 American Transplant Congress
Clinical Significance of Tacrolimus Trough Level at the Early Period after Kidney Transplantation
W. Park,^1,2 S. Yeo,¹ S. Kang,^1,2 H. Park,¹ K. Jin,^1,2 S. Park,^1,2 S. Han.^1,2
¹Internal Medicine, Keimyung University School of Medicine, Daegu, Republic of Korea; ²Keimyung University Kidney Institute, Daegu, Republic of Korea.
Background:The stable immunosuppressant level at the early period after kidney transplantation (KT) is one of the most important factors to decide the prognosis of KT.…
2018 American Transplant Congress
Does DGF Result in Worse Outcomes in a Second Transplant?
B. Muth,¹ B. Astor,^1,2 J. Blazel,¹ J. Turk,¹ D. Mandelbrot,¹ A. Djamali,¹ S. Parajuli.¹
¹Department of Medicine, University of Wisconsin, Madison, WI; ²Department of Population Health, University of Wisconsin, Madison, WI.
Delayed graft function (DGF) is a risk factor for patient death, kidney allograft loss, reduced allograft function and acute rejection after kidney transplantation. Prior transplant…
2018 American Transplant Congress
Single-Dose Basiliximab Induction in Liver Transplant Recipients with Delayed CNI Initiation
D. Salerno,¹ N. Lange,¹ R. Rosenblatt,² C. Sammons,³ B. Fortune.²
¹Pharmacy, NewYork-Presbyterian Hospital, New York, NY; ²Medicine, Weill Cornell Medicine, New York, NY; ³Pharmacy, Hospital of the University of Pennsylvania, Philadelphia, PA.
Liver transplant recipients (LTR) with peri-operative renal injury benefit from a delayed CNI protocol using basiliximab (IL2RA) induction to reduce early CNI exposure. Existing literature…