Articles tagged "Rejection"

2018 American Transplant Congress
Delayed Achievement of Therapeutic Tacrolimus Levels after Renal Transplantation is Not Associated with Increased Incidence of Early Acute Rejection: Single-Center Results
R. Marshall, J. Brandenberger, A. Cantafio, J. Halldorson, R. Bakthavatsalam, A. Dick, S. Rayhill, J. Reyes, J. Perkins.
Division of Transplant Surgery, Department of Surgery, University of Washington, Seattle, WA.
Induction therapy followed by maintenance with a calcineurin inhibitor aims to minimize the incidence of early rejection and optimize the potential for allograft function. However…
2018 American Transplant Congress
The Protective Effect of Multivisceral Transplantation on Intestinal Allograft Rejection – Its Correlation with T-Cell Macrochimerism from a Long-Term Prospective Study
P. Liou,¹ M. Martinez,¹ J. Fu,² M. Velasco,¹ A. Griesemer,¹ S. Lobritto,¹ J. Vittorio,¹ S. Ravella,¹ B. Levin,³ J. Emond,¹ M. Sykes,² T. Kato.¹
¹Center for Liver Disease and Transplantation, Columbia University, New York, NY; ²Columbia Center for Translational Immunology, Columbia University, New York, NY; ³Department of Biostatistics, Columbia University, New York, NY.
Objective Graft rejection remains the crux of intestinal transplantation. Although liver-inclusive grafts appear to be protective, the mechanism remains unknown. We hypothesize that T-cell macrochimerism…
2018 American Transplant Congress
Inflammation in Scarred Areas (I-IFTA) is a Reflection of Parenchymal Injury (Response to Wounding) Not T Cell-Mediated Rejection
P. Halloran, J. Chang, K. Famulski.
Medicine, University of Alberta, Edmonton, AB, Canada.
Inflammation in fibrotic renal parenchyma (i-IFTA) is associated with decreased graft survival but by Banff rules is not diagnostic for rejection. Some researchers believe that…
2018 American Transplant Congress
Donor Reactive Eomesdermin^hiCD8⁺ T Cells Are Significantly Upregulated Early after Transplant in Kidney Transplant Patients without Rejection
A. Perez-Gutierrez,^1,2 D. Metes,¹ S. Hariharan,¹ A. Thomson,¹ M. Ezzelarab.¹
¹Surgery, Thomas Starzl Transplantation Institute, Pittsburgh, PA; ²Surgery, Transplantation Institute, University of Chicago, Chicago, IL.
IntroductionMemory T cell responses play a critical role in the outcome of allo-transplantation. While the role of the T-box transcription factor Eomesodermin (Eomes) in the…
2018 American Transplant Congress
Prospective Multicenter Validation of Human Transitional B Cell Cytokines as a Predictive Biomarker in Renal Transplantation
A. Cherukuri,¹ D. Chittka,¹ A. Sharma,¹ A. Salama,² C. Magee,² D. Rothstein.¹
¹UPMC, Pittsburgh; ²UCL, London, United Kingdom.
In renal transplantation, non-invasive biomarkers are needed to identify patients at risk for poor outcomes and guide pre-emptive therapy. Here, we assessed B cell cytokines…
2018 American Transplant Congress
Intragraft MicroRNA Transcriptome of Acute Antibody Mediated Rejection of Human Kidney Allografts
H. Yang,¹ K. Akat,² C. Li,¹ C. Snopkowski,¹ Z. Khan,¹ D. Dadhania,¹ T. Tuschl,² M. Suthanthiran,¹ T. Muthukumar.¹
¹Weill Cornell Medicine, New York; ²Rockefeller University, New York.
BackgroundMicroRNAs (miRNA) are master regulators of gene expression and are potential therapeutic targets. Intragraft miRNA transcriptome of acute antibody rejection (AMR) of human kidney allograft…
2018 American Transplant Congress
Molecular Monitoring for Kidney Allograft Injury Following HLA Incompatible Transplantation
A. Jackson,¹ B. Iglehart,¹ S. Bagnasco,³ N. Desai.²
¹Medicine, Johns Hopkins University, Baltimore, MD; ²Surgery, Johns Hopkins University, Baltimore, MD; ³Pathology, Johns Hopkins University, Baltimore, MD.
Elevated donor derived cell free DNA (ddcfDNA) has been shown to correlate with allograft rejection following heart, lung, and kidney transplantation. We investigated whether sequential…
2018 American Transplant Congress
Temporal Variability of IgG Subclasses
D. Pinelli, M. Gopalakrishnan, A. Joong, P. Thrush, A. Tambur.
Northwestern University, Chicago; Lurie Children's Hospital, Chicago.
The temporal model of IgG subclass switching supports sequential IgG conversion; however, the diversity of previously stimulated B cells is known to shape responses in…
2018 American Transplant Congress
Genome-Wide Association Study Assessing Risk of Rejection in Pediatric Transplant Recipients
T. Papaz,¹ S. Min,¹ O. Lee,¹ T. Blydt-Hansen,³ U. Allen,¹ Y. Avitzur,¹ P. Birk,² B. Foster,⁴ H. Grasemann,¹ L. Hamiwka,⁵ R. Parekh,¹ V. Phan,⁶ S. Urschel,⁷ S. Mital.¹
¹SickKids Hospital, Toronto, ON, Canada; ²Winnipeg Children's Hospital, Winnipeg, MB, Canada; ³BC Children's Hospital, Vancouver, BC, Canada; ⁴Montreal Children's Hospital, Montreal, QC, Canada; ⁵Alberta Children's Hospital, Calgary, AB, Canada; ⁶CHU Sainte Justines, Montreal, QC, Canada; ⁷Stollery Children's Hospital, Edmonton, AB, Canada.
Background: Rejection risk varies after solid organ transplantation (SOT). We explored genomic variants associated with susceptibility to graft rejection.Methods: SOTs enrolled in a multicenter prospective…
2018 American Transplant Congress
The Efficacy and Safety of Rituximab as Induction Therapy in Kidney Transplantation: A Meta-Analysis of Randomized Controlled Trials
X. Wang,¹ J. Chen,² X. Tu,² Y. Qiu,¹ T. Song,¹ T. Lin.¹
¹Department of Urology/Institute of Urology/Organ Transplantation Center, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China; ²West China School of Clinical Medicine, Sichuan University, Chengdu, Sichuan Province, China.
Objectives. This meta-analysis was undertaken to assess the efficacy and safety of rituximab as induction therapy in kidney transplantation.Methods. OVID, Embase, SCI, PubMed and EBSCO…