Articles tagged "Rejection"

2022 American Transplant Congress
Effect of Covid-19 Vaccination on Markers of Rejection in Heart Transplant Recipients
Z. Pieters¹, E. Bruno¹, S. Kim¹, S. De Sirkar¹, M. Thomas¹, S. B. Sharmin², M. Liebo¹, A. Heroux¹, N. Clark¹, G. Reid¹, S. Uprichard², M. Yu¹
¹Medicine, Loyola University Medical Center, Maywood, IL, ²Loyola University Chicago, Chicago, IL
*Purpose: Heart transplant recipients have worse survival with COVID-19 than the general population, highlighting the importance of vaccination in these patients. The impact of vaccination…
2022 American Transplant Congress
Complete and High-Resolution HLA Typing Improves the Accuracy of Post-Transplant Assessment of De Novo Anti-Donor Immune-Mediated Events
M. Meneghini¹, A. Perona², E. Crespo³, F. J. Bemelman⁴, P. M. Reinke⁵, O. Viklicky⁶, M. Giral⁷, O. Bestard¹
¹Vall d'Hebron University Hospital, Barcelona, Spain, ²Universitat de Barcelona, Barcelona, Spain, ³Nephrology and Transplantation Laboratory, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain, ⁴Amsterdam University Medical Centers, Amsterdam, Netherlands, ⁵Charité Universitätsmedizin, Berlin, Germany, ⁶Institute for Clinical and Experimental Medicine (IKEM), Prague, Czech Republic, ⁷Nantes Université, Inserm, CHU Nantes, Nantes, France
*Purpose: High-resolution (HR) HLA typing using NGS technology has shown to improve the accuracy of assessing donor-recipient compatibility and characterization of pre-transplant anti HLA antibodies…
2022 American Transplant Congress
Is Pathologic AMR Grading Scale Associated with the Presence of Donor-Specific Antibodies?
S. Kim, J. Patel, M. Kittleson, T. Singer-Englar, N. Patel, D. Chang, E. Kransdorf, D. Emerson, J. A. Kobashigawa
Cedars-Sinai Smidt Heart Institute, Los Angeles, CA
*Purpose: Antibody-mediated rejection (AMR) has been defined by an expert pathology group in 2011 which resulted in the ISHLT pathologic AMR (pAMR) grading scale. The…
2022 American Transplant Congress
Role of Urinary Biomarkers in RWE Clinical Paradigm
W. Yazar¹, R. Sarwal², N. Titzler¹, M. Sarwal¹, S. Ghosh²
¹Nephrosant, Brisbane, CA, ²NephroSant, Brisbane, CA
*Purpose: Due to heterogeneity observed in the kidney transplant population, it has been extremely challenging for traditional methods such as histopathology to predict graft outcomes.…
2022 American Transplant Congress
Surveillance with Allosure for Allograft Rejection and Infection in Lung Transplant
M. M. Botros¹, N. Sulejmani², B. F. Reader³, B. C. Keller¹
¹Pulmonary, Critical Care & Sleep Medicine, The Ohio State University, Columbus, OH, ²Medical Affairs, CareDx, South San Francisco, CA, ³Division of Transplant Surgery, The Ohio State University, Columbus, OH
*Purpose: Measurement of plasma donor-derived cell-free DNA (dd-cfDNA; AlloSure, CareDx) has been shown to be a useful non-invasive diagnostic test for injury and infection after…
2022 American Transplant Congress
The Intracellular Tacrolimus Concentration in CD3⁺ T Lymphocytes and CD14⁺ Monocytes and Its Association with Kidney Transplant Rejection
S. Udomkarnjananun, C. Baan, B. de Winter, D. Hesselink
Erasmus MC, Rotterdam, Netherlands
*Purpose: The intracellular tacrolimus concentration in peripheral blood mononuclear cells (PBMCs) (TAC[PBMC]) was proposed to better represent active concentration than pre-dose whole blood concentration (C0).…
2022 American Transplant Congress
Natural Antibodies Are Associated With Rejection And Long-term Renal Allograft Loss In A Multi-center International Cohort
S. B. See¹, X. Yang², C. Burger³, B. Lamarthée⁴, R. Snanoudj⁵, R. Shihab¹, D. S. Tsapepas⁶, P. Roy¹, S. Larivière-Beaudoin⁷, K. Hamelin⁷, A. Mendoza Rojas⁸, N. M. van Besouw⁸, A. Bartosic⁹, N. Daniel⁹, E. R. Vasilescu¹⁰, S. Mohan¹¹, D. Cohen¹¹, L. Ratner¹¹, C. C. Baan⁸, J. S. Bromberg⁹, H. Cardinal⁷, D. Anglicheau³, Y. Sun², E. Zorn¹
¹CCTI, Columbia University Irving Medical Center, New York, NY, ²Biostatistics, Columbia University Irving Medical Center, New York, NY, ³Necker Hospital, Paris, France, ⁴Necker-Enfants Malades Institute, Paris, France, ⁵Bicêtre Hospital, Paris, France, ⁶Surgery, Columbia University Irving Medical Center, New York, NY, ⁷CHUM, Montreal, QC, Canada, ⁸Erasmus MC, Rotterdam, Netherlands, ⁹Surgery, University of Maryland School of Medicine, Baltimore, MD, ¹⁰Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, ¹¹Medicine, Columbia University Irving Medical Center, New York, NY
*Purpose: Potentially harmful non-donor-specific human leukocyte antigen antibodies have been identified in renal transplantation, including natural IgG antibodies (Nabs) reactive to varied antigenic structures.*Methods: In…
2022 American Transplant Congress
Conversion to Belatacept for Calcineurin Inhibitor Toxicities
S. S. Patel, P. Jadav, M. Sekulic, S. Kudose, I. Batal, S. Mohan, R. Crew
Columbia University Medical Center, New York, NY
*Purpose: Calcineurin inhibitors (CNIs) have improved renal transplant (RTx) outcomes but are associated with significant toxicities. Belatacept provides better long-term outcomes than cyclosporine, has less…
2022 American Transplant Congress
Urinary Cell CTOT-04 Signature is Diagnostic of Glomerulitis in Kidney Allograft Biopsies
T. Salinas¹, C. Li¹, C. Snopkowski¹, K. Chen¹, S. Albakry¹, S. Salvatore², S. Seshan², J. R. Lee¹, M. Thangamani¹, D. Dadhania¹, M. Suthanthiran¹
¹Nephrology, Weill Cornell-NYPH, New York, NY, ²Pathology, Weill Cornell-NYPH, New York, NY
*Purpose: Antibody mediated rejection is a significant complication after kidney transplantation and is an important cause of allograft failure. In the multicenter CTOT-04 study, we…
2022 American Transplant Congress
3D Co-Culture System with Porcine Aortic Endothelial Cell Line and Human or Non-Human Primate Cells for Application in the Study of Xeno-Immune Reaction
S. K. Yadav¹, Y. Lee², S. Hurh³, S. Kim², J. Yang⁴, J. C. Jeong²
¹Medicine, Seoul National University, Seoul, Korea, Republic of, ²Internal Medicine (Nephrology), Seoul National University Bundang Hospital, Seongnam, Korea, Republic of, ³Medicine, Korea University, Seoul, Korea, Republic of, ⁴Internal Medicine (Nephrology), Yonsei University, Seoul, Korea, Republic of
*Purpose: Neutrophil Extracellular Trap (NET) is a vigorous immune reaction of neutrophil. It plays role in xenotransplantation rejection. Functional assay of NET is important; however,…