Articles tagged "Rejection"

2022 American Transplant Congress
Novel Role of CD74 in Regulatory T Cell Homeostasis and Function in Allo-Immune Response
Z. Solhjou¹, H. Zhang¹, N. Younis¹, J. Choi¹, C. Deban¹, A. Saad¹, A. Halawi¹, Z. Jing¹, R. Bucala², J. Azzi¹
¹Brigham and Women's Hospital, Boston, MA, ²Yale University School of Medicine, New Haven, CT
*Purpose: Identifying new molecular targets based on our understanding of the biology of the allo-immune response in the allograft microenvironment is critical to develop more…
2022 American Transplant Congress
Analysis of Induction Dose and Incidence of CMV Viremia in High Risk (HR; D+/R-) Renal Transplant Recipients
K. Shimko, M. Pittappilly, R. Chowdhury, H. Karimi, C. Puttarajappa, M. Wijkstrom, R. Mehta
University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: Depleting induction puts patients at risk of opportunistic infections. Our protocol aims for 5-6mg/kg cumulative dose of antithymocyte globulin(ATG) divided over 4 doses. It…
2022 American Transplant Congress
Single Cell And Spatial Transcriptomics Of Blood And Biopsies Reveals Enhanced Alloantigen Presenting Function And T-follicular Helper Cell (tfh) Expansion Early After Pediatric Liver Transplantation
R. Sindhi¹, C. Ashokkumar¹, M. Ningappa¹, D. Rajasundaram¹, B. W. Higgs¹, Q. Xu², A. Zeevi², M. Reyes-Mugica¹
¹Childrens Hospital of Pittsburgh of UPMC, Pittsburgh, PA, ²University of Pittsburgh Medical Center, Pittsburgh, PA
*Purpose: We have previously reported enhanced B-cell presentation of donor antigen during early T-cell mediated liver transplant (LT) rejection.*Methods: To characterize B-cell related immunological mechanisms…
2022 American Transplant Congress
A Signature of Tolerance Which Identifies Subclinical Rejection-Free Patients at One Year After Kidney Transplantation
R. Danger¹, L. Le Berre¹, M. Cadoux¹, C. Kerleau¹, P. Guérif¹, E. Morelon², O. Thaunat², C. Legendre³, D. Anglicheau³, K. Renaudin¹, M. Giral¹, S. Brouard¹
¹Centre de Recherche en Transplantation et Immunologie (CRTI), UMR 1064, ITUN, Nantes Université, CHU Nantes, Inserm, Nantes, France, ²Edouard Herriot Hospital, Hospices Civils de Lyon, Inserm U1111, Lyon-Est Medical Faculty, Claude Bernard University (Lyon 1), Lyon, France, ³APHP, Necker-Enfants Malades Institute, Inserm, Paris University, Paris, France
*Purpose: Spontaneous and rare cases of patients undergoing a functional renal transplant in the absence of immunosuppression represent a particular situation of immune tolerance. We…
2022 American Transplant Congress
Utilizing Microporous Annealed Particle (MAP) Gel as an Immunomodulatory Carrier for Islet Delivery
M. Ma¹, P. Chhabra¹, C. Roosa², D. R. Griffin², K. L. Brayman¹
¹Department of Surgery, University of Virginia Health System, Charlottesville, VA, ²Department of Biomedical Engineering, University of Virginia Health System, Charlottesville, VA
*Purpose: To investigate if coating with MAP gel improves dissociated or whole islet transplantation outcome.*Background: MAP gel platform technology is composed of hydrogel microspheres that…
2022 American Transplant Congress
Early Outcomes of Single Dose Eculizumab for Abo-Incompatible Living Donor Renal Transplantation
K. Heagler, M. Campara, P. Di Cocco, S. Gaitonde, I. Tang, J. Almario Alvarez, M. Spaggiari, J. Benken, C. S. Muran, B. Valdepenas, D. Pierce, I. Tzvetanov, E. Benedetti
UI Health, Chicago, IL
*Purpose: Use of ABO-incompatible (ABOi) donors increases access to living donor renal transplantation (LDRT). Conventional desensitization with plasmapheresis (PLEX) allows safe ABOi transplantation when pre-transplant…
2022 American Transplant Congress
Association of Pre-Transplant Anti A1 IgM Antibody Titers with Survival Outcomes in A2/A2B to B Kidney Transplantation
M. Fallahzadeh, D. Shaffer, A. El Chediak, I. Feurer, S. Rega, J. L. Triozzi, S. Shawar
Vanderbilt University Medical Center, Nashville, TN
*Purpose: The new kidney allocation system implemented in 2014 has allowed blood type B recipients to receive kidneys from A2/A2B donors. Although many centers use…
2022 American Transplant Congress
Evaluating Long Term Outcomes in Kidney Transplant Patients with TruGraf Gene Expression and TRAC Dd-cfdna in the TRULO Study
P. West-Thielke, W. Ally, J. Hickey, L. Stach, J. Fleming, T. Cober, A. Kawano, I. Agboli, C. Miller, J. Holman
Eurofins Transplant Genomics, Framingham, MA
*Purpose: The aim of this study is to evaluate long term clinical outcomes in kidney transplant patients undergoing non-invasive rejection monitoring with the OmniGraf® biomarker…
2022 American Transplant Congress
Recipient Treatment with Anti-CD122 mAb Prolongs Kidney Allograft Survival During Antibody-Mediated Rejection without Impacting NK Cell Activation within the Graft
D. Okada, S. Miyairi, N. Dvorina, K. S. Keslar, A. Valujskikh, W. Baldwin, R. Fairchild
Cleveland Clinic, Cleveland, OH
*Purpose: Dysregulated donor-specific antibody (DSA) responses are induced in B6.CCR5-/- mice transplanted with complete MHC mismatched kidney allografts and are required for rejection of the…
2022 American Transplant Congress
Long-Term (>1 Year) Rejection Free Graft Survival of Kidney Xenografts with Triple Xenoantigen Knockout and Multiple Human Transgenes in Cynomolgus Monkeys
T. Hirose¹, G. Lassiter¹, D. Ma¹, A. D'Attilio¹, I. Rosales¹, D. Cloonan¹, R. Matheson¹, R. Colvin¹, W. Qin², Y. Kan², J. Layer², R. Anand², V. Paragas², L. Queroz², X. Tan², I. Kohnle², K. Stiede², K. Hall², M. Youd², M. Curtis², J. Markmann¹, T. Kawai¹
¹Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA, ²eGenesis Inc, Cambridge, MA
*Purpose: Pigs with deletion of 3 carbohydrate xenoantigens (triple knock-out, TKO) are expected to be optimal donors for human xenotransplantation. We have previously shown that…