Articles tagged "Rejection"

2022 American Transplant Congress
Delta Changes in Donor-Derived Cell-Free DNA (dd-cfDNA) Complement the Donor Fraction in Kidney Transplant Surveillance
A. Wiseman¹, M. Jagadeesan², G. Gupta³, V. Rao⁴, M. Narayanan⁵, N. Agrawal⁶, G. Shekhtman⁶, Y. Fu⁶, K. Pinney⁶, S. Anand⁷
¹Centura Health, Denver, CO, ²George Washington University, Washington, DC, ³Virginia Commonwealth University, Richmond, VA, ⁴Medical University of South Carolina, Charleston, SC, ⁵Baylor Scott and White, Austin, TX, ⁶CareDx, Brisbane, CA, ⁷Intermountain Healthcare, Murray, UT
*Purpose: Delta changes in dd-cfDNA levels over time may identify patients with evolving alloimmune injury, providing complementary information to the donor fraction. We explored the…
2022 American Transplant Congress
Use of De Novo mTOR Inhibitors in Highly Sensitized Kidney Transplant Recipients
J. Bastos¹, T. Freesz², C. Bisi³, C. Marinho², A. Pires², V. Colares³, R. Neto², G. Ferreira²
¹Tranplant Unit, Santa Casa De Misericordia De Juiz de Fora, Juiz de Fora, Brazil, ²Transplant Unit, Santa Casa De Misericórdia De Juiz de Fora, Juiz de Fora, Brazil, ³Tranplant Unit, Santa Casa De Misericórdia De Juiz de Fora, Juiz de Fora, Brazil
*Purpose: mTOR inhibitors (mTORi) allow calcineurin-inhibitor reduction without loss of efficacy and may improve allograft-transplant outcomes. However, the safety of this protocol in high-immunological risk…
2022 American Transplant Congress
Re-Examining the Optimal Threshold for Donor Derived Cell Free DNA in Renal Allograft Rejection
H. Murad¹, M. Merzkani¹, M. Ji¹, S. Chang¹, A. Malone¹, R. Delos Santos¹, T. Alhamad²
¹Washington University in St. Louis, St Louis, MO, ²Washington University in St. Louis, Saint Louis, MO
*Purpose: Due to the invasive nature and potential complications of allograft biopsies, there is an important role for surrogate biomarkers to help identify rejection early,…
2022 American Transplant Congress
Treatment Modality and Outcomes of Antibody-Mediated Rejection in Pediatric Kidney Transplant Recipients: The PARAMOUr Study
R. Engen¹, A. Jain², N. Hayde³, A. Mansuri⁴, M. Kallash⁵, S. McEwen⁶, R. Garro⁷, C. Peterson⁸, R. Zahr⁹, L. Harshman¹⁰, D. Puliyanda¹¹, S. Solomon¹², K. Twombley¹³, I. Ashoor¹⁴
¹Pediatrics, University of Wisconsin Madison, Madison, WI, ²Wayne State University, Detroit, MI, ³Albert Einstein College of Medicine, New York, NY, ⁴Augusta University, Augusta, GA, ⁵The Ohio State University, Columbus, OH, ⁶University of Minnesota, Minneapolis, MN, ⁷Emory University, Atlanta, GA, ⁸University of Utah Health, Salt Lake City, UT, ⁹The University of Tennessee Health Science Center, Memphis, TN, ¹⁰University of Iowa, Iowa City, IA, ¹¹Cedars-Sinai Medical Center, Los Angeles, CA, ¹²New York Medical College, Valhalla, NY, ¹³Medical University of South Carolina, Charleston, SC, ¹⁴Louisiana State University, New Orleans, LA
*Purpose: Antibody-mediated rejection (AMR) is the leading cause of graft failure in kidney transplantation, but evidence for effective treatments is limited.*Methods: PARAMOUr is a retrospective…
2022 American Transplant Congress
High Pretransplant FGF-23 Level is Associated with Poor Graft Survival and Persistent Vitamin D Insufficiency in Kidney Transplant Patients
J. Ryu¹, H. Jeon², T. Koo³, J. Yang⁴
¹Internal Medicine, Ewha Womans University College of Medicine, Seoul, Korea, Republic of, ²Department of Internal Medicine, Hallym University College of Medicine, Kangdong Sacred Heart Hospital, Seoul, Korea, Republic of, ³Internal Medicine, Seongnam Citizens Medical Center, Seongnam, Korea, Republic of, ⁴Internal Medicine, Yonsei University College of Medicine, Severance Hospital, Seoul, Korea, Republic of
*Purpose: Vitamin D [25(OH)D] insufficiency and FGF-23 elevation in chronic kidney disease (CKD) is usually ameliorated after kidney transplantation (KT). However, post-transplant vitamin D insufficiency…
2022 American Transplant Congress
Autologous Mesenchymal Stem Cells for Treatment of Chronic Antibody-Mediated Kidney Graft Rejection: Report of the First Phase I/II Clinical Case Series
Ž. Večerić-Haler¹, M. Sever², N. Kojc³, G. Mlinšek¹, M. Oblak¹, P. Halloran⁴, A. Aleš Rigler¹, J. Buturović Ponikvar¹, M. Arnol⁵
¹Nephrology, UMC Ljubljans, Ljubljana, Slovenia, ²Haematology, UMC Ljubljans, Ljubljana, Slovenia, ³Institute of Pathology, Faculty of Medicine, University of Ljubljana, Ljubljana,, Ljubljana, Slovenia, ⁴Division of Nephrology and Transplant Immunology, University of Alberta, Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ⁵University Medical Centre Ljubljana, Ljubljana, Slovenia
*Purpose: The aim of this study is to evaluate the safety and efficacy of autologous mesenchymal stem cellc (MSCs) in combination with standard of care…
2022 American Transplant Congress
HLA-DRB1 and DQB1 Amino Acid Mismatches as Determinants of Kidney Allograft Failure
L. Gragert¹, K. P. McCullough², G. L. Wager³, R. Urbanowicz⁴, R. M. Merion², M. Kamoun⁴
¹Tulane Cancer Center, Tulane University, New Orleans, LA, ²Arbor Research Collaborative for Health, Ann Arbor, MI, ³Tulane University, New Orleans, LA, ⁴University of Pennsylvania, Philadelphia, PA
*Purpose: It was previously reported that HLA-DRB1 amino acid (AA) mismatches (MMs) at peptide-binding pockets of this molecule account for significant incremental risk of kidney…
2022 American Transplant Congress
A Real-World Analysis with the Molecular Microscope Diagnostic System in Dual-Organ Transplant Recipients
J. M. Blair¹, J. Van Zyl², G. P. Milligan³, S. M. McKean², R. Patel², S. A. Hall⁴, A. Alam³
¹Cardiology, Baylor University Medical Center at Dallas, Dallas, TX, ²Baylor University Medical Center at Dallas, Dallas, TX, ³Advanced Heart Failure & Transplant Cardiology, Baylor University Medical Center at Dallas, Dallas, TX, ⁴Transplant Cardiology and Mechanical Support/Heart Failure, Baylor University Medical Center at Dallas, Dallas, TX
*Purpose: The Molecular Microscope Diagnostic System (MMDx) analyzes ribonucleic acid transcripts to provide sophisticated differentiation amongst T-cell mediated rejection (TCMR), antibody mediated rejection (AMR), injury…
2022 American Transplant Congress
Of the Individual Components of a Modified Freid Frailty Score, Pre-Transplant Walk Time and Grip Strength Are the Strongest Predictors of Post Kidney Transplant Outcomes
S. Parajuli, F. Aziz, H. L. Lorden, K. A. O'Toole, R. E. Wallschlaeger, I. C. Breyer, B. Dodin, J. Goronzik Wang, D. A. Mandelbrot
University of Wisconsin, Madison, WI
*Purpose: Frailty assessment has become common during evaluation for kidney transplantation; however, a variety of different tools are used for frailty assessment. The Freid frailty…
2022 American Transplant Congress
Gm2a: A Novel Regulatory Pathway Controlling CD8⁺ T Cell Alloimmunity
K. M. Baecher¹, J. Bazzano¹, K. Tong¹, M. Fribourg², P. Cravedi², P. S. Heeger², M. L. Ford¹
¹Department of Surgery, Emory University, Atlanta, GA, ²Mount Sinai School of Medicine, New York, NY
*Purpose: Transplant recipients experience lifelong immunosuppression, yet studies have shown that a subset of patients may be able to retain stable graft function even with…