ATC Abstracts

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Articles tagged "Rapamycin"

  • 2015 American Transplant Congress

    Targeted Rapamycin Nanotherapy Dampens Memory T Cell Function

    S. Nadig,1 S. Esckilsen,1 A.-M. Broome,2 S. Dixit,2 C. Atkinson.3

    1Surgery, Microbiology and Immunology, Medical University of South Carolina, Charleston, SC; 2Radiologic Sciences, Medical University of South Carolina, Charleston, SC; 3Microbiology and Immunology, Medical University of South Carolina, Charleston, SC.

    Memory T cells (Tm) are difficult to control post-transplantation and account for early rejection episodes. Additionally, therapies exerting local immunosuppression by targeting an allograft, while…
  • 2015 American Transplant Congress

    Responsiveness to Rituximab, Plasmapheresis and Intravenous Immunoglobulins in Antibody Mediated Rejections After Kidney and Pancreas – Kidney Transplantation

    E. Minué,1 L. León,1 P. Uva,1 A. Dotta,1 J. Walther,1 O. Casanova,1 F. Togniolo,1 O. Guardia,1 M. Rial,1 E. Chuluyan,2 D. Casadei.1

    1Instituto de Nefrologia, Nephrology, Buenos Aires, Argentina; 2CEFYBO, Universidad de Buenos Aires-CONICET, Buenos Aires, Argentina.

    The antibody-mediated rejection (AMR) has become clinically critical because this form of rejection is usually unresponsive to conventional anti-rejection therapy. Therefore, it has been recognized…
  • 2015 American Transplant Congress

    Inhibition of mTOR Modulates SLPI Expression: A Potential Role in Kidney Transplant Patients

    N. Ambrosi,1 A. Dotta,2 C. Pizarro,2 D. Guerrieri,1 A. Gonzalez,2 C. Leiva,2 L. Leon,2 J. Mendiberri,3 M. Rial,2 C. Incardona,4 E. Chuluyan,1 D. Casadei.2

    1CEFYBO, UBA, Buenos Aires, Argentina; 2Fundacion 3er Milenio, INBA, Buenos Aires, Argentina; 3UNICEN, Olavarria, Argentina; 4Fundación GADOR, Buenos Aires, Argentina.

    Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor secreted by inflammatory and epithelial cells. It functions as an endogenous immunomodulatory, with antiinflammatory and…
  • 2015 American Transplant Congress

    Pregnancy Outcomes in Solid Organ Transplant Recipients With Exposure to Sirolimus Without Mycophenolate

    N. Sifontis,1 L. Coscia,2 D. Armenti,2 S. Constantinescu,2,3 M. Moritz.2,4

    1Pharmacy Practice, Temple University, Philadelphia; 2National Transplantation Pregnancy Registry, Gift of Life Institute, Philadelphia; 3Temple University School of Medicine, Philadelphia; 4Lehigh Valley Health Network, Allentown.

    Results of prior sirolimus series reports have been confounded by concomitant mycophenolate exposure. The purpose of this study was to describe pregnancy outcomes with exposure…
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