Articles tagged "Rapamycin"

2015 American Transplant Congress
Marked Suppression of Posttransplant Alloantibody Production and Primed B cell Function In Vivo by mTOR Inhibition Compared to Calcineurin Inhibition
C. Wright, J. Zimmerer, T. Pham, G. Bumgardner.
Department of Surgery, CTC, The Ohio State University, Columbus, OH.
mTOR inhibitors [mTORi; Rapamycin, (Rapa)] and calcineurin inhibitors [CNi; Tacrolimus (Tac)] are immunosuppressives commonly used to suppress rejection of transplants. Despite widespread use following transplantation…
2015 American Transplant Congress
Ex Vivo Expansion With Rapamycin Enhances the Suppressive Function of Regulatory T Cells (Tregs) Isolated from Pediatric Thymus
E. Dijke,^1,2,3 R. Hoeppli,^3,4 T. Ellis,^1,2 J. Pearcey,^1,2 I. Larsen,^1,2 I. Rebeyka,^1,2 D. Ross,^1,2 M. Levings,^3,4 L. West.^1,2,3
¹University of Alberta, Edmonton, AB, Canada; ²Alberta Transplant Institute, Edmonton, AB, Canada; ³Canadian National Transplant Research Program, Edmonton/Vancouver, AB/BC, Canada; ⁴University of British Columbia, Vancouver, BC, Canada.
INTRODUCTION: Treg-based cellular therapy to suppress graft-directed immunity could reduce the need for life-long immunosuppressive drugs. Challenges include isolation and expansion of pure Tregs to…
2015 American Transplant Congress
CXCR4-SDF1α Blockade Reduces the Severity of Murine Heart Allograft Rejection
X. Wang,¹ J. Fu,¹ B. Wilde,¹ L. Jing,¹ J. Zhu,¹ A. Kribben,¹ O. Witzke,¹ A. Hoerning.^2,3
¹Department of Nephrology, University Hospital Essen, University Duisburg-Essen, Essen, Germany; ²Department of Pediatrics II, University Hospital Essen, University Duisburg-Essen, Essen, Germany; ³Department of Pediatric and Adolescent Medicine, University Hospital Erlangen, Friedrich-Alexander University Erlangen, Erlangen, Germany.
Introduction: The interaction of the CXCR4/SDF1α axis plays a critical role in the retention of hematopoietic stem cells in bone marrow. We hypothesized that the…
2015 American Transplant Congress
Non-Cytoreductive Immunosuppression Prevents Rejection of Vascularized Composite Allografts
B. Oh, G. Furtmüller, M. Fryer, G. Raimondi, D. Cooney, W. Lee, G. Brandacher.
Department of Plastic and Reconstructive Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, United Kingdom.
[Background] Reconstructive transplantation represents a valid therapeutic option after devastating tissue loss such as an extremity or face. Immunosuppression-free donor-specific immunological tolerance has been successfully…