2016 American Transplant Congress
Heterologous Persistent and Latent Viral Infections Do Not Impact Graft Survival.
1Duke University, Durham; 2Emory University, Atlanta.
Purpose: Infection induces costimulation-resistant memory T cells with heterologous alloreactivity. Rapamycin has been shown to mitigate the effect of these cells in transplant rejection. Previous…2015 American Transplant Congress
Marked Suppression of Posttransplant Alloantibody Production and Primed B cell Function In Vivo by mTOR Inhibition Compared to Calcineurin Inhibition
Department of Surgery, CTC, The Ohio State University, Columbus, OH.
mTOR inhibitors [mTORi; Rapamycin, (Rapa)] and calcineurin inhibitors [CNi; Tacrolimus (Tac)] are immunosuppressives commonly used to suppress rejection of transplants. Despite widespread use following transplantation…2015 American Transplant Congress
Ex Vivo Expansion With Rapamycin Enhances the Suppressive Function of Regulatory T Cells (Tregs) Isolated from Pediatric Thymus
INTRODUCTION: Treg-based cellular therapy to suppress graft-directed immunity could reduce the need for life-long immunosuppressive drugs. Challenges include isolation and expansion of pure Tregs to…2015 American Transplant Congress
CXCR4-SDF1α Blockade Reduces the Severity of Murine Heart Allograft Rejection
Introduction: The interaction of the CXCR4/SDF1α axis plays a critical role in the retention of hematopoietic stem cells in bone marrow. We hypothesized that the…2015 American Transplant Congress
Non-Cytoreductive Immunosuppression Prevents Rejection of Vascularized Composite Allografts
[Background] Reconstructive transplantation represents a valid therapeutic option after devastating tissue loss such as an extremity or face. Immunosuppression-free donor-specific immunological tolerance has been successfully…2015 American Transplant Congress
Targeted Rapamycin Nanotherapy Dampens Memory T Cell Function
Memory T cells (Tm) are difficult to control post-transplantation and account for early rejection episodes. Additionally, therapies exerting local immunosuppression by targeting an allograft, while…2015 American Transplant Congress
Responsiveness to Rituximab, Plasmapheresis and Intravenous Immunoglobulins in Antibody Mediated Rejections After Kidney and Pancreas – Kidney Transplantation
The antibody-mediated rejection (AMR) has become clinically critical because this form of rejection is usually unresponsive to conventional anti-rejection therapy. Therefore, it has been recognized…2015 American Transplant Congress
Inhibition of mTOR Modulates SLPI Expression: A Potential Role in Kidney Transplant Patients
Secretory leukocyte protease inhibitor (SLPI) is a serine protease inhibitor secreted by inflammatory and epithelial cells. It functions as an endogenous immunomodulatory, with antiinflammatory and…2015 American Transplant Congress
Pregnancy Outcomes in Solid Organ Transplant Recipients With Exposure to Sirolimus Without Mycophenolate
Results of prior sirolimus series reports have been confounded by concomitant mycophenolate exposure. The purpose of this study was to describe pregnancy outcomes with exposure…2015 American Transplant Congress
"What's the Mileage?" Determining the Length of Time in Which Renal Function Returns to Pre-Calcineurin Discontinuation Levels in Patients With Interstitial Fibrosis
The Ohio State University, Columbus.
Calcineurin Inhibitors (CNI) use may be associated with progressive renal dysfunction. Clinical trials have shown that CNI minimization or discontinuation may aid in improvement in…
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